Is a body mass index of less than 18.5 kg/m2 associated with an increased susceptibility to mild cognitive impairment? A cross-sectional study conducted in China
Objective Investigating the correlation between body mass index (BMI) and cognitive decline among elderly people in the Chinese community.Design A non-random sampling method was employed to conduct a cross-sectional, mixed methods survey among elderly individuals in the Chinese community.Setting Thi...
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BMJ Publishing Group
2024-12-01
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| author | Wei Li Ling Yue Shifu Xiao Lin Sun |
| author_facet | Wei Li Ling Yue Shifu Xiao Lin Sun |
| author_sort | Wei Li |
| collection | DOAJ |
| description | Objective Investigating the correlation between body mass index (BMI) and cognitive decline among elderly people in the Chinese community.Design A non-random sampling method was employed to conduct a cross-sectional, mixed methods survey among elderly individuals in the Chinese community.Setting This research was conducted across the country, focusing on 20 distinct communities (2 rural and 18 urban) situated in the eastern, central and western parts of China.Participants The China Longitudinal Aging Study (cohort 1) and Shanghai Brain Aging study (cohort 2) were the sources of the present data. Cohort 1 consisted of 2947 individuals aged 60 and above, who were subjected to a comprehensive screening procedure encompassing a physical examination, medical background and initial evaluations of cognitive abilities through an in-person interview. Cohort 2 comprised an extra 226 older adults, including 54 patients with mild cognitive impairment (MCI) and 174 normal adults, and unlike cohort 1, all of them underwent T1 phase MRI scans.Outcome measures The cognitive abilities, BMI and structural magnetic resonance properties of elderly individuals in the Chinese community.Results In cohort 1, we discovered that having a BMI below 18.5 kg/m2 posed a significant risk for MCI (p=0.005, OR=2.000, 95% CI: 1.228 to 3.255), regardless of age, gender and other significant variables. Despite this, there was no correlation between dementia and various BMIs. In cohort 2, we found that both left and right hippocampal volumes were significantly smaller in patients with MCI than in normal older adults, and there was a clear mediating effect between the right hippocampus, BMI and cognitive impairment (r=2.182, p=0.030).Conclusions BMI below 18.5 kg/m2 is associated with an increased likelihood of mild cognitive decline, which may be related to the effect of BMI on the volume of the right hippocampus. |
| format | Article |
| id | doaj-art-3170d8433f1b4c26bf75e0215236de2d |
| institution | OA Journals |
| issn | 2044-6055 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMJ Publishing Group |
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| series | BMJ Open |
| spelling | doaj-art-3170d8433f1b4c26bf75e0215236de2d2025-08-20T01:56:55ZengBMJ Publishing GroupBMJ Open2044-60552024-12-01141210.1136/bmjopen-2023-076622Is a body mass index of less than 18.5 kg/m2 associated with an increased susceptibility to mild cognitive impairment? A cross-sectional study conducted in ChinaWei Li0Ling Yue1Shifu Xiao2Lin Sun34 Medical Research & Biometrics Center, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China1 Department of Clinical Psychology, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Geriatric Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University, Shanghai, China1Peking University Third Hospital, Department of Rheumatology and Immunology, Beijing, ChinaObjective Investigating the correlation between body mass index (BMI) and cognitive decline among elderly people in the Chinese community.Design A non-random sampling method was employed to conduct a cross-sectional, mixed methods survey among elderly individuals in the Chinese community.Setting This research was conducted across the country, focusing on 20 distinct communities (2 rural and 18 urban) situated in the eastern, central and western parts of China.Participants The China Longitudinal Aging Study (cohort 1) and Shanghai Brain Aging study (cohort 2) were the sources of the present data. Cohort 1 consisted of 2947 individuals aged 60 and above, who were subjected to a comprehensive screening procedure encompassing a physical examination, medical background and initial evaluations of cognitive abilities through an in-person interview. Cohort 2 comprised an extra 226 older adults, including 54 patients with mild cognitive impairment (MCI) and 174 normal adults, and unlike cohort 1, all of them underwent T1 phase MRI scans.Outcome measures The cognitive abilities, BMI and structural magnetic resonance properties of elderly individuals in the Chinese community.Results In cohort 1, we discovered that having a BMI below 18.5 kg/m2 posed a significant risk for MCI (p=0.005, OR=2.000, 95% CI: 1.228 to 3.255), regardless of age, gender and other significant variables. Despite this, there was no correlation between dementia and various BMIs. In cohort 2, we found that both left and right hippocampal volumes were significantly smaller in patients with MCI than in normal older adults, and there was a clear mediating effect between the right hippocampus, BMI and cognitive impairment (r=2.182, p=0.030).Conclusions BMI below 18.5 kg/m2 is associated with an increased likelihood of mild cognitive decline, which may be related to the effect of BMI on the volume of the right hippocampus.https://bmjopen.bmj.com/content/14/12/e076622.full |
| spellingShingle | Wei Li Ling Yue Shifu Xiao Lin Sun Is a body mass index of less than 18.5 kg/m2 associated with an increased susceptibility to mild cognitive impairment? A cross-sectional study conducted in China BMJ Open |
| title | Is a body mass index of less than 18.5 kg/m2 associated with an increased susceptibility to mild cognitive impairment? A cross-sectional study conducted in China |
| title_full | Is a body mass index of less than 18.5 kg/m2 associated with an increased susceptibility to mild cognitive impairment? A cross-sectional study conducted in China |
| title_fullStr | Is a body mass index of less than 18.5 kg/m2 associated with an increased susceptibility to mild cognitive impairment? A cross-sectional study conducted in China |
| title_full_unstemmed | Is a body mass index of less than 18.5 kg/m2 associated with an increased susceptibility to mild cognitive impairment? A cross-sectional study conducted in China |
| title_short | Is a body mass index of less than 18.5 kg/m2 associated with an increased susceptibility to mild cognitive impairment? A cross-sectional study conducted in China |
| title_sort | is a body mass index of less than 18 5 kg m2 associated with an increased susceptibility to mild cognitive impairment a cross sectional study conducted in china |
| url | https://bmjopen.bmj.com/content/14/12/e076622.full |
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