Therapeutic potential and mechanism of functional oligosaccharides in inflammatory bowel disease: a review
Inflammatory bowel disease (IBD) is characterized by recurrent attacks and long courses, and the number of patients has expanded rapidly year by year. Additionally, current conventional strategies exist serious adverse effects. In this case, it is an urgent issue to find out an effective and safe tr...
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| Format: | Article |
| Language: | English |
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Tsinghua University Press
2023-11-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453023000794 |
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| author | Xiaochun Yang Deyong Zeng Chongyang Li Wenchen Yu Guilin Xie Yingchun Zhang Weihong Lu |
| author_facet | Xiaochun Yang Deyong Zeng Chongyang Li Wenchen Yu Guilin Xie Yingchun Zhang Weihong Lu |
| author_sort | Xiaochun Yang |
| collection | DOAJ |
| description | Inflammatory bowel disease (IBD) is characterized by recurrent attacks and long courses, and the number of patients has expanded rapidly year by year. Additionally, current conventional strategies exist serious adverse effects. In this case, it is an urgent issue to find out an effective and safe treatment. Functional oligosaccharides possess safe and excellent physiological activities, and have attracted enormous attention due to their great therapeutic potential for IBD. This review emphasizes the attenuating effects of distinct functional oligosaccharides on IBD and their structure, and summarizes the main mechanisms from the aspects of regulating intestinal flora structure, repairing intestinal barrier, modulating immune function and mediating related signaling pathways in order to reveal the relationship between functional oligosaccharides, immune regulation, intestinal epithelial cells, gut flora and IBD treatment. Oligosaccharides possess excellent protective effects on IBD, and can be considered as safe and functional ingredients in the health food and pharmaceutical industry. |
| format | Article |
| id | doaj-art-316f7deed1bc4af19b2755b418c89a35 |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2023-11-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-316f7deed1bc4af19b2755b418c89a352025-02-03T05:55:57ZengTsinghua University PressFood Science and Human Wellness2213-45302023-11-0112621352150Therapeutic potential and mechanism of functional oligosaccharides in inflammatory bowel disease: a reviewXiaochun Yang0Deyong Zeng1Chongyang Li2Wenchen Yu3Guilin Xie4Yingchun Zhang5Weihong Lu6School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150001, ChinaSchool of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150001, ChinaSichuan Gongda Southwest Food Research Co., Ltd., Bazhong 636063, ChinaSchool of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150001, ChinaSichuan Gongda Southwest Food Research Co., Ltd., Bazhong 636063, ChinaSchool of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150001, China; Corresponding authors.School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150001, China; Sichuan Gongda Southwest Food Research Co., Ltd., Bazhong 636063, China; The Intelligent Equipment Research Center for the Exploitation of Characteristic Food & Medicine Resources, Chongqing Research Institute of Harbin Institute of Technology, Chongqing 401135, China; Corresponding authors.Inflammatory bowel disease (IBD) is characterized by recurrent attacks and long courses, and the number of patients has expanded rapidly year by year. Additionally, current conventional strategies exist serious adverse effects. In this case, it is an urgent issue to find out an effective and safe treatment. Functional oligosaccharides possess safe and excellent physiological activities, and have attracted enormous attention due to their great therapeutic potential for IBD. This review emphasizes the attenuating effects of distinct functional oligosaccharides on IBD and their structure, and summarizes the main mechanisms from the aspects of regulating intestinal flora structure, repairing intestinal barrier, modulating immune function and mediating related signaling pathways in order to reveal the relationship between functional oligosaccharides, immune regulation, intestinal epithelial cells, gut flora and IBD treatment. Oligosaccharides possess excellent protective effects on IBD, and can be considered as safe and functional ingredients in the health food and pharmaceutical industry.http://www.sciencedirect.com/science/article/pii/S2213453023000794OligosaccharidesColitisPathogenesisSignaling pathwayAction mechanism |
| spellingShingle | Xiaochun Yang Deyong Zeng Chongyang Li Wenchen Yu Guilin Xie Yingchun Zhang Weihong Lu Therapeutic potential and mechanism of functional oligosaccharides in inflammatory bowel disease: a review Food Science and Human Wellness Oligosaccharides Colitis Pathogenesis Signaling pathway Action mechanism |
| title | Therapeutic potential and mechanism of functional oligosaccharides in inflammatory bowel disease: a review |
| title_full | Therapeutic potential and mechanism of functional oligosaccharides in inflammatory bowel disease: a review |
| title_fullStr | Therapeutic potential and mechanism of functional oligosaccharides in inflammatory bowel disease: a review |
| title_full_unstemmed | Therapeutic potential and mechanism of functional oligosaccharides in inflammatory bowel disease: a review |
| title_short | Therapeutic potential and mechanism of functional oligosaccharides in inflammatory bowel disease: a review |
| title_sort | therapeutic potential and mechanism of functional oligosaccharides in inflammatory bowel disease a review |
| topic | Oligosaccharides Colitis Pathogenesis Signaling pathway Action mechanism |
| url | http://www.sciencedirect.com/science/article/pii/S2213453023000794 |
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