Capsaicin‐mediated repair of circadian disruption‐induced Intestinal barrier damage via the gut microbiota
Abstract Circadian clock serves as a regulator of gastrointestinal health, and the disruption of circadian rhythm may trigger the dysregulation of the intestinal barrier functions. This study investigated the effectiveness of capsaicin (CAP) in mitigating intestinal barrier dysfunction induced by ci...
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| Format: | Article |
| Language: | English |
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Wiley
2024-11-01
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| Series: | Food Frontiers |
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| Online Access: | https://doi.org/10.1002/fft2.467 |
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| author | Yupei Deng Bolin Lin Chi‐Tang Ho Jie Xiao Yong Cao Jun‐qing Huang Muwen Lu |
| author_facet | Yupei Deng Bolin Lin Chi‐Tang Ho Jie Xiao Yong Cao Jun‐qing Huang Muwen Lu |
| author_sort | Yupei Deng |
| collection | DOAJ |
| description | Abstract Circadian clock serves as a regulator of gastrointestinal health, and the disruption of circadian rhythm may trigger the dysregulation of the intestinal barrier functions. This study investigated the effectiveness of capsaicin (CAP) in mitigating intestinal barrier dysfunction induced by circadian disruption in male SPF C57BL/6J mice. Our findings indicated that CAP supplementation attenuated abnormal weight gain, alterations in serum lipid levels, and misalignment in hepatic and colonic circadian clock gene expressions in mice caused by constant darkness (CD) treatment. The restoration of the intestinal barrier integrity was also observed through the increase in mucosal thickness and goblet cell numbers. Both the diversity and the circadian rhythm of gut microbiota were improved in CAP‐treated group. Correlation analysis indicated that CAP could modulate the gut microbiota by affecting intestinal barrier function and systemic metabolism in CD‐treated mice. These results highlight the potential of CAP as a functional food component in maintaining the intestinal barrier homeostasis through regulating gut microbiota. |
| format | Article |
| id | doaj-art-31618555b63b4e01b9ed6b16fce4b58c |
| institution | OA Journals |
| issn | 2643-8429 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Food Frontiers |
| spelling | doaj-art-31618555b63b4e01b9ed6b16fce4b58c2025-08-20T02:12:25ZengWileyFood Frontiers2643-84292024-11-01562579259010.1002/fft2.467Capsaicin‐mediated repair of circadian disruption‐induced Intestinal barrier damage via the gut microbiotaYupei Deng0Bolin Lin1Chi‐Tang Ho2Jie Xiao3Yong Cao4Jun‐qing Huang5Muwen Lu6Guangdong Provincial Key Laboratory of Nutraceuticals and Functional Foods, College of Food Science South China Agricultural University Guangzhou ChinaGuangdong Provincial Key Laboratory of Nutraceuticals and Functional Foods, College of Food Science South China Agricultural University Guangzhou ChinaDepartment of Food Science Rutgers University New Brunswick New Jersey USAGuangdong Provincial Key Laboratory of Nutraceuticals and Functional Foods, College of Food Science South China Agricultural University Guangzhou ChinaGuangdong Provincial Key Laboratory of Nutraceuticals and Functional Foods, College of Food Science South China Agricultural University Guangzhou ChinaSchool of Traditional Chinese Medicine Jinan University Guangzhou ChinaGuangdong Provincial Key Laboratory of Nutraceuticals and Functional Foods, College of Food Science South China Agricultural University Guangzhou ChinaAbstract Circadian clock serves as a regulator of gastrointestinal health, and the disruption of circadian rhythm may trigger the dysregulation of the intestinal barrier functions. This study investigated the effectiveness of capsaicin (CAP) in mitigating intestinal barrier dysfunction induced by circadian disruption in male SPF C57BL/6J mice. Our findings indicated that CAP supplementation attenuated abnormal weight gain, alterations in serum lipid levels, and misalignment in hepatic and colonic circadian clock gene expressions in mice caused by constant darkness (CD) treatment. The restoration of the intestinal barrier integrity was also observed through the increase in mucosal thickness and goblet cell numbers. Both the diversity and the circadian rhythm of gut microbiota were improved in CAP‐treated group. Correlation analysis indicated that CAP could modulate the gut microbiota by affecting intestinal barrier function and systemic metabolism in CD‐treated mice. These results highlight the potential of CAP as a functional food component in maintaining the intestinal barrier homeostasis through regulating gut microbiota.https://doi.org/10.1002/fft2.467capsaicincircadian clockgut microbiotaintestinal barrier function |
| spellingShingle | Yupei Deng Bolin Lin Chi‐Tang Ho Jie Xiao Yong Cao Jun‐qing Huang Muwen Lu Capsaicin‐mediated repair of circadian disruption‐induced Intestinal barrier damage via the gut microbiota Food Frontiers capsaicin circadian clock gut microbiota intestinal barrier function |
| title | Capsaicin‐mediated repair of circadian disruption‐induced Intestinal barrier damage via the gut microbiota |
| title_full | Capsaicin‐mediated repair of circadian disruption‐induced Intestinal barrier damage via the gut microbiota |
| title_fullStr | Capsaicin‐mediated repair of circadian disruption‐induced Intestinal barrier damage via the gut microbiota |
| title_full_unstemmed | Capsaicin‐mediated repair of circadian disruption‐induced Intestinal barrier damage via the gut microbiota |
| title_short | Capsaicin‐mediated repair of circadian disruption‐induced Intestinal barrier damage via the gut microbiota |
| title_sort | capsaicin mediated repair of circadian disruption induced intestinal barrier damage via the gut microbiota |
| topic | capsaicin circadian clock gut microbiota intestinal barrier function |
| url | https://doi.org/10.1002/fft2.467 |
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