All roads lead to glutamate: NMDA and AMPA receptors as targets for rapid-acting antidepressants

All roads lead to glutamate: NMDA and AMPA receptors as targets for rapid-acting antidepressants

Treatment-resistant depression (TRD) represents a major clinical challenge. Affecting about 30 % of major depressive disorder (MDD) patients, effective treatments for TRD are urgently needed. While depression research and antidepressant (AD) development have long centred on monoaminergic targets, re...

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Bibliographic Details
Main Authors: Florian Freudenberg, Christine Reif-Leonhard, Gerard R. Dawson, Ruth M. McKernan, Andreas Reif
Format: Article
Language:English
Published: Elsevier 2025-10-01
Series:Pharmacological Research
Subjects:
Rapid acting antidepressants
Major depressive disorder
Unipolar depression
Treatment resistant depression
Ketamine
NMDA
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661825003433
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