Recent Advances in Dielectrophoretic Manipulation and Separation of Microparticles and Biological Cells
Dielectrophoresis (DEP) is an advanced microfluidic manipulation technique that is based on the interaction of polarized particles with the spatial gradient of a non-uniform electric field to achieve non-contact and highly selective manipulation of particles. In recent years, DEP has made remarkable...
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MDPI AG
2024-08-01
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| Series: | Biosensors |
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| author | Junzhu Yao Kai Zhao Jia Lou Kaihuan Zhang |
| author_facet | Junzhu Yao Kai Zhao Jia Lou Kaihuan Zhang |
| author_sort | Junzhu Yao |
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| description | Dielectrophoresis (DEP) is an advanced microfluidic manipulation technique that is based on the interaction of polarized particles with the spatial gradient of a non-uniform electric field to achieve non-contact and highly selective manipulation of particles. In recent years, DEP has made remarkable progress in the field of microfluidics, and it has gradually transitioned from laboratory-scale research to high-throughput manipulation in practical applications. This paper reviews the recent advances in dielectric manipulation and separation of microparticles and biological cells and discusses in detail the design of chip structures for the two main methods, direct current dielectrophoresis (DC-DEP) and alternating current dielectrophoresis (AC-DEP). The working principles, technical implementation details, and other improved designs of electrode-based and insulator-based chips are summarized. Functional customization of DEP systems with specific capabilities, including separation, capture, purification, aggregation, and assembly of particles and cells, is then performed. The aim of this paper is to provide new ideas for the design of novel DEP micro/nano platforms with the desired high throughput for further development in practical applications. |
| format | Article |
| id | doaj-art-315eefff37c14a48b3cb933a513829c9 |
| institution | OA Journals |
| issn | 2079-6374 |
| language | English |
| publishDate | 2024-08-01 |
| publisher | MDPI AG |
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| series | Biosensors |
| spelling | doaj-art-315eefff37c14a48b3cb933a513829c92025-08-20T01:56:05ZengMDPI AGBiosensors2079-63742024-08-0114941710.3390/bios14090417Recent Advances in Dielectrophoretic Manipulation and Separation of Microparticles and Biological CellsJunzhu Yao0Kai Zhao1Jia Lou2Kaihuan Zhang3Liaoning Key Laboratory of Marine Sensing and Intelligent Detection, Department of Information Science and Technology, Dalian Maritime University, Dalian 116026, ChinaLiaoning Key Laboratory of Marine Sensing and Intelligent Detection, Department of Information Science and Technology, Dalian Maritime University, Dalian 116026, China2020 X-Lab, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, China2020 X-Lab, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, ChinaDielectrophoresis (DEP) is an advanced microfluidic manipulation technique that is based on the interaction of polarized particles with the spatial gradient of a non-uniform electric field to achieve non-contact and highly selective manipulation of particles. In recent years, DEP has made remarkable progress in the field of microfluidics, and it has gradually transitioned from laboratory-scale research to high-throughput manipulation in practical applications. This paper reviews the recent advances in dielectric manipulation and separation of microparticles and biological cells and discusses in detail the design of chip structures for the two main methods, direct current dielectrophoresis (DC-DEP) and alternating current dielectrophoresis (AC-DEP). The working principles, technical implementation details, and other improved designs of electrode-based and insulator-based chips are summarized. Functional customization of DEP systems with specific capabilities, including separation, capture, purification, aggregation, and assembly of particles and cells, is then performed. The aim of this paper is to provide new ideas for the design of novel DEP micro/nano platforms with the desired high throughput for further development in practical applications.https://www.mdpi.com/2079-6374/14/9/417dielectrophoresismicrofluidicscell separationintegratedmicroparticle manipulation |
| spellingShingle | Junzhu Yao Kai Zhao Jia Lou Kaihuan Zhang Recent Advances in Dielectrophoretic Manipulation and Separation of Microparticles and Biological Cells Biosensors dielectrophoresis microfluidics cell separation integrated microparticle manipulation |
| title | Recent Advances in Dielectrophoretic Manipulation and Separation of Microparticles and Biological Cells |
| title_full | Recent Advances in Dielectrophoretic Manipulation and Separation of Microparticles and Biological Cells |
| title_fullStr | Recent Advances in Dielectrophoretic Manipulation and Separation of Microparticles and Biological Cells |
| title_full_unstemmed | Recent Advances in Dielectrophoretic Manipulation and Separation of Microparticles and Biological Cells |
| title_short | Recent Advances in Dielectrophoretic Manipulation and Separation of Microparticles and Biological Cells |
| title_sort | recent advances in dielectrophoretic manipulation and separation of microparticles and biological cells |
| topic | dielectrophoresis microfluidics cell separation integrated microparticle manipulation |
| url | https://www.mdpi.com/2079-6374/14/9/417 |
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