Epidemiology of SLE in Italy: an observational study using a primary care database
Objectives To estimate the incidence and prevalence of SLE in Italy, and to describe the demographic and clinical characteristics of patients with newly diagnosed SLE.Methods A retrospective cohort study was conducted using The Health Improvement Network general practice database in Italy, encompass...
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BMJ Publishing Group
2024-05-01
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| Series: | Lupus Science and Medicine |
| Online Access: | https://lupus.bmj.com/content/11/1/e001162.full |
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| author | Pietro Ferrara Giacomo Emmi Lorenzo G Mantovani Alessandra Bettiol Giampiero Mazzaglia Carla Fornari Cristiana Borrelli Irene Mattioli Manuel Zamparini Ippazio C Antonazzo Silvia Boarino Pasquale Palladino Elena Zanzottera Ferrari |
| author_facet | Pietro Ferrara Giacomo Emmi Lorenzo G Mantovani Alessandra Bettiol Giampiero Mazzaglia Carla Fornari Cristiana Borrelli Irene Mattioli Manuel Zamparini Ippazio C Antonazzo Silvia Boarino Pasquale Palladino Elena Zanzottera Ferrari |
| author_sort | Pietro Ferrara |
| collection | DOAJ |
| description | Objectives To estimate the incidence and prevalence of SLE in Italy, and to describe the demographic and clinical characteristics of patients with newly diagnosed SLE.Methods A retrospective cohort study was conducted using The Health Improvement Network general practice database in Italy, encompassing data from 634 753 people. SLE cases were identified over the period 2017–2022, employing three alternative definitions to provide a more detailed understanding of SLE characteristics. Incidence rates were expressed as cases per 100 000 person-years and prevalence as cases per 100 000 people. Demographic and clinical characteristics of incident SLE cases were also studied.Results From 2017 to 2022, a total of 191 incident and 1385 prevalent cases were identified under our first definition. In 2022, the incidence rate was 6.51 cases (95% CI 6.29 to 6.74) per 100 000 person-years, and the prevalence 60.57 (95% CI 59.89 to 61.25) per 100 000 people, being the prevalence five times higher in women compared with men. Both estimates have trended upwards since 2017. A geographical variation across the country was also seen. The demographic and clinical characteristics of incident SLE cases were described, while the potential associations of SLE incidence with some pre-existing conditions were observed, such as chronic kidney disease, chronic hepatic disease, rheumatoid arthritis and Sjogren’s syndrome.Conclusions The results of this nationwide study, the first conducted in Italy, showed that the incidence of SLE has increased in Italy in recent years. Age, sex, and area of residence strongly correlate with the epidemiology of this condition. |
| format | Article |
| id | doaj-art-31596cd7b31742e08dc3cd315d7777b2 |
| institution | OA Journals |
| issn | 2053-8790 |
| language | English |
| publishDate | 2024-05-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | Lupus Science and Medicine |
| spelling | doaj-art-31596cd7b31742e08dc3cd315d7777b22025-08-20T01:58:51ZengBMJ Publishing GroupLupus Science and Medicine2053-87902024-05-0111110.1136/lupus-2024-001162Epidemiology of SLE in Italy: an observational study using a primary care databasePietro Ferrara0Giacomo Emmi1Lorenzo G Mantovani2Alessandra Bettiol3Giampiero Mazzaglia4Carla Fornari5Cristiana Borrelli6Irene Mattioli7Manuel Zamparini8Ippazio C Antonazzo9Silvia Boarino10Pasquale Palladino11Elena Zanzottera Ferrari12Laboratory of Public Health, Istituto Auxologico Italiano Istituto di Ricovero e Cura a Carattere Scientifico, Milano, ItalyDepartment of Experimental and Clinical Medicine, University of Florence, Firenze, ItalyCenter for Public Health Research, University of Milan-Bicocca, Monza, ItalyDepartment of Experimental and Clinical Medicine, University of Florence, Firenze, ItalyCenter for Public Health Research, University of Milan-Bicocca, Monza, ItalyCenter for Public Health Research, University of Milan-Bicocca, Monza, ItalyMedical Affairs Department, AstraZeneca, Milan, ItalyDepartment of Experimental and Clinical Medicine, University of Florence, Firenze, ItalyCenter for Public Health Research, University of Milan-Bicocca, Monza, ItalyCenter for Public Health Research, University of Milan-Bicocca, Monza, ItalyMedical Affairs Department, AstraZeneca, Milan, ItalyCegedim Health Data, Milan, ItalyCegedim Health Data, Milan, ItalyObjectives To estimate the incidence and prevalence of SLE in Italy, and to describe the demographic and clinical characteristics of patients with newly diagnosed SLE.Methods A retrospective cohort study was conducted using The Health Improvement Network general practice database in Italy, encompassing data from 634 753 people. SLE cases were identified over the period 2017–2022, employing three alternative definitions to provide a more detailed understanding of SLE characteristics. Incidence rates were expressed as cases per 100 000 person-years and prevalence as cases per 100 000 people. Demographic and clinical characteristics of incident SLE cases were also studied.Results From 2017 to 2022, a total of 191 incident and 1385 prevalent cases were identified under our first definition. In 2022, the incidence rate was 6.51 cases (95% CI 6.29 to 6.74) per 100 000 person-years, and the prevalence 60.57 (95% CI 59.89 to 61.25) per 100 000 people, being the prevalence five times higher in women compared with men. Both estimates have trended upwards since 2017. A geographical variation across the country was also seen. The demographic and clinical characteristics of incident SLE cases were described, while the potential associations of SLE incidence with some pre-existing conditions were observed, such as chronic kidney disease, chronic hepatic disease, rheumatoid arthritis and Sjogren’s syndrome.Conclusions The results of this nationwide study, the first conducted in Italy, showed that the incidence of SLE has increased in Italy in recent years. Age, sex, and area of residence strongly correlate with the epidemiology of this condition.https://lupus.bmj.com/content/11/1/e001162.full |
| spellingShingle | Pietro Ferrara Giacomo Emmi Lorenzo G Mantovani Alessandra Bettiol Giampiero Mazzaglia Carla Fornari Cristiana Borrelli Irene Mattioli Manuel Zamparini Ippazio C Antonazzo Silvia Boarino Pasquale Palladino Elena Zanzottera Ferrari Epidemiology of SLE in Italy: an observational study using a primary care database Lupus Science and Medicine |
| title | Epidemiology of SLE in Italy: an observational study using a primary care database |
| title_full | Epidemiology of SLE in Italy: an observational study using a primary care database |
| title_fullStr | Epidemiology of SLE in Italy: an observational study using a primary care database |
| title_full_unstemmed | Epidemiology of SLE in Italy: an observational study using a primary care database |
| title_short | Epidemiology of SLE in Italy: an observational study using a primary care database |
| title_sort | epidemiology of sle in italy an observational study using a primary care database |
| url | https://lupus.bmj.com/content/11/1/e001162.full |
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