Baseline Renal Function Predicts Hyponatremia in Liver Cirrhosis Patients Treated with Terlipressin for Variceal Bleeding
Objectives. Terlipressin is safely used for acute variceal bleeding. However, side effects, such as hyponatremia, although very rare, can occur. We investigated the development of hyponatremia in cirrhotic patients who had acute variceal bleeding treated with terlipressin and the identification of t...
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| Language: | English |
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Wiley
2017-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2017/7610374 |
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| author | Sung Eun Kim Dong Min Jung Ji Won Park Yeonmi Ju Bohyun Lee Hyoung Su Kim Ki Tae Suk Myoung Kuk Jang Sang Hoon Park Jun Goo Kang Jae Seung Soh Hyun Lim Ho Suk Kang Sung Hoon Moon ChulSik Kim SeongJin Lee Jong Hyeok Kim Myung Seok Lee Dong Joon Kim Sung-Hee Ihm ChoongKee Park |
| author_facet | Sung Eun Kim Dong Min Jung Ji Won Park Yeonmi Ju Bohyun Lee Hyoung Su Kim Ki Tae Suk Myoung Kuk Jang Sang Hoon Park Jun Goo Kang Jae Seung Soh Hyun Lim Ho Suk Kang Sung Hoon Moon ChulSik Kim SeongJin Lee Jong Hyeok Kim Myung Seok Lee Dong Joon Kim Sung-Hee Ihm ChoongKee Park |
| author_sort | Sung Eun Kim |
| collection | DOAJ |
| description | Objectives. Terlipressin is safely used for acute variceal bleeding. However, side effects, such as hyponatremia, although very rare, can occur. We investigated the development of hyponatremia in cirrhotic patients who had acute variceal bleeding treated with terlipressin and the identification of the risk factors associated with the development of hyponatremia. Design and Methods. This retrospective, case-control study investigated 88 cirrhotic patients who developed hyponatremia and 176 controls that did not develop hyponatremia and were matched in terms of age and gender during the same period following terlipressin administration. Results. The overall change in serum sodium concentration and the mean lowest serum sodium concentration were 3.44 ± 9.55 and 132.44 ± 8.78 mEq/L during treatment, respectively. Multivariate analysis revealed that baseline serum sodium was an independent positive predictor, and the presence of baseline serum creatinine, HBV, DM, creatinine, and shock on admission was independent negative predictors of hyponatremia (P<0.05). Conclusion. The presence of HBV, DM, the baseline serum sodium, shock on admission, and especially baseline creatinine may be predictive of the development of hyponatremia after terlipressin treatment. Therefore, physicians conduct vigilant monitoring associated with severe hyponatremia when cirrhotic patients with preserved renal function are treated with terlipressin for variceal bleeding. |
| format | Article |
| id | doaj-art-3158ec64dceb4e528952f0fefd7878b1 |
| institution | OA Journals |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-3158ec64dceb4e528952f0fefd7878b12025-08-20T02:38:53ZengWileyGastroenterology Research and Practice1687-61211687-630X2017-01-01201710.1155/2017/76103747610374Baseline Renal Function Predicts Hyponatremia in Liver Cirrhosis Patients Treated with Terlipressin for Variceal BleedingSung Eun Kim0Dong Min Jung1Ji Won Park2Yeonmi Ju3Bohyun Lee4Hyoung Su Kim5Ki Tae Suk6Myoung Kuk Jang7Sang Hoon Park8Jun Goo Kang9Jae Seung Soh10Hyun Lim11Ho Suk Kang12Sung Hoon Moon13ChulSik Kim14SeongJin Lee15Jong Hyeok Kim16Myung Seok Lee17Dong Joon Kim18Sung-Hee Ihm19ChoongKee Park20Department of Internal Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Republic of KoreaDepartment of Internal Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Republic of KoreaDepartment of Internal Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Republic of KoreaDepartment of Internal Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Republic of KoreaDepartment of Internal Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Republic of KoreaDepartment of Internal Medicine, Hallym University Gangdong Sacred Heart Hospital, Gangdong, Republic of KoreaDepartment of Internal Medicine, Hallym University Chuncheon Sacred Heart Hospital, Chuncheon, Republic of KoreaDepartment of Internal Medicine, Hallym University Gangdong Sacred Heart Hospital, Gangdong, Republic of KoreaDepartment of Internal Medicine, Hallym University Gangnam Sacred Heart Hospital, Seoul, Republic of KoreaDepartment of Internal Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Republic of KoreaDepartment of Internal Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Republic of KoreaDepartment of Internal Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Republic of KoreaDepartment of Internal Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Republic of KoreaDepartment of Internal Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Republic of KoreaDepartment of Internal Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Republic of KoreaDepartment of Internal Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Republic of KoreaDepartment of Internal Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Republic of KoreaDepartment of Internal Medicine, Hallym University Gangnam Sacred Heart Hospital, Seoul, Republic of KoreaDepartment of Internal Medicine, Hallym University Chuncheon Sacred Heart Hospital, Chuncheon, Republic of KoreaDepartment of Internal Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Republic of KoreaDepartment of Internal Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Republic of KoreaObjectives. Terlipressin is safely used for acute variceal bleeding. However, side effects, such as hyponatremia, although very rare, can occur. We investigated the development of hyponatremia in cirrhotic patients who had acute variceal bleeding treated with terlipressin and the identification of the risk factors associated with the development of hyponatremia. Design and Methods. This retrospective, case-control study investigated 88 cirrhotic patients who developed hyponatremia and 176 controls that did not develop hyponatremia and were matched in terms of age and gender during the same period following terlipressin administration. Results. The overall change in serum sodium concentration and the mean lowest serum sodium concentration were 3.44 ± 9.55 and 132.44 ± 8.78 mEq/L during treatment, respectively. Multivariate analysis revealed that baseline serum sodium was an independent positive predictor, and the presence of baseline serum creatinine, HBV, DM, creatinine, and shock on admission was independent negative predictors of hyponatremia (P<0.05). Conclusion. The presence of HBV, DM, the baseline serum sodium, shock on admission, and especially baseline creatinine may be predictive of the development of hyponatremia after terlipressin treatment. Therefore, physicians conduct vigilant monitoring associated with severe hyponatremia when cirrhotic patients with preserved renal function are treated with terlipressin for variceal bleeding.http://dx.doi.org/10.1155/2017/7610374 |
| spellingShingle | Sung Eun Kim Dong Min Jung Ji Won Park Yeonmi Ju Bohyun Lee Hyoung Su Kim Ki Tae Suk Myoung Kuk Jang Sang Hoon Park Jun Goo Kang Jae Seung Soh Hyun Lim Ho Suk Kang Sung Hoon Moon ChulSik Kim SeongJin Lee Jong Hyeok Kim Myung Seok Lee Dong Joon Kim Sung-Hee Ihm ChoongKee Park Baseline Renal Function Predicts Hyponatremia in Liver Cirrhosis Patients Treated with Terlipressin for Variceal Bleeding Gastroenterology Research and Practice |
| title | Baseline Renal Function Predicts Hyponatremia in Liver Cirrhosis Patients Treated with Terlipressin for Variceal Bleeding |
| title_full | Baseline Renal Function Predicts Hyponatremia in Liver Cirrhosis Patients Treated with Terlipressin for Variceal Bleeding |
| title_fullStr | Baseline Renal Function Predicts Hyponatremia in Liver Cirrhosis Patients Treated with Terlipressin for Variceal Bleeding |
| title_full_unstemmed | Baseline Renal Function Predicts Hyponatremia in Liver Cirrhosis Patients Treated with Terlipressin for Variceal Bleeding |
| title_short | Baseline Renal Function Predicts Hyponatremia in Liver Cirrhosis Patients Treated with Terlipressin for Variceal Bleeding |
| title_sort | baseline renal function predicts hyponatremia in liver cirrhosis patients treated with terlipressin for variceal bleeding |
| url | http://dx.doi.org/10.1155/2017/7610374 |
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