Surface plasmon resonance detection of anti-cancer drug flutamide by graphitic carbon nitride/chitosan nanocomposite
Abstract The g-C3N4/CS biosensor was designed, fabricated, and tested using compounds such as glucose, urine, lactose, and flutamide at a molarity of 10 µM, which could demonstrate a high sensitivity of 200 μm-1 for flutamide. Powerful effective medium theory and FDTD simulation were used to predict...
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Nature Portfolio
2025-01-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-86665-w |
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| author | Hassan Nasiri Karim Abbasian |
| author_facet | Hassan Nasiri Karim Abbasian |
| author_sort | Hassan Nasiri |
| collection | DOAJ |
| description | Abstract The g-C3N4/CS biosensor was designed, fabricated, and tested using compounds such as glucose, urine, lactose, and flutamide at a molarity of 10 µM, which could demonstrate a high sensitivity of 200 μm-1 for flutamide. Powerful effective medium theory and FDTD simulation were used to predict the most favorable mode and plasmonic properties of a graphite carbon nitride and chitosan nanocomposite. The research also explores the characteristics of surface plasmon resonance exhibited by the nanocomposite as the chitosan content is adjusted. Subsequent simulations are conducted on nanocomposites incorporating a thin layer and a modified gold structure. The intricate simulations ultimately reveal the optimal combination, tested under three different pH conditions (6.2, 7.2, and 8). In acidic conditions, the kinetic profile yielded a KD= 3.45 × 10−7, surpassing the KD value of a thin film. The Au significantly outperformed the alternative material. The biosensor demonstrated linear behavior across a wide concentration range from 1 to 150 µM, achieving a detection limit of 120 nM with its high sensitivity. |
| format | Article |
| id | doaj-art-31523d0f123a41569ccc875ea16b9dc2 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-31523d0f123a41569ccc875ea16b9dc22025-01-26T12:34:05ZengNature PortfolioScientific Reports2045-23222025-01-011511910.1038/s41598-025-86665-wSurface plasmon resonance detection of anti-cancer drug flutamide by graphitic carbon nitride/chitosan nanocompositeHassan Nasiri0Karim Abbasian1Faculty of Electrical and Computer Engineering, University of TabrizFaculty of Electrical and Computer Engineering, University of TabrizAbstract The g-C3N4/CS biosensor was designed, fabricated, and tested using compounds such as glucose, urine, lactose, and flutamide at a molarity of 10 µM, which could demonstrate a high sensitivity of 200 μm-1 for flutamide. Powerful effective medium theory and FDTD simulation were used to predict the most favorable mode and plasmonic properties of a graphite carbon nitride and chitosan nanocomposite. The research also explores the characteristics of surface plasmon resonance exhibited by the nanocomposite as the chitosan content is adjusted. Subsequent simulations are conducted on nanocomposites incorporating a thin layer and a modified gold structure. The intricate simulations ultimately reveal the optimal combination, tested under three different pH conditions (6.2, 7.2, and 8). In acidic conditions, the kinetic profile yielded a KD= 3.45 × 10−7, surpassing the KD value of a thin film. The Au significantly outperformed the alternative material. The biosensor demonstrated linear behavior across a wide concentration range from 1 to 150 µM, achieving a detection limit of 120 nM with its high sensitivity.https://doi.org/10.1038/s41598-025-86665-wSPR sensorFlutamide biosensorGraphitic-carbon nitrite-chitosan |
| spellingShingle | Hassan Nasiri Karim Abbasian Surface plasmon resonance detection of anti-cancer drug flutamide by graphitic carbon nitride/chitosan nanocomposite Scientific Reports SPR sensor Flutamide biosensor Graphitic-carbon nitrite-chitosan |
| title | Surface plasmon resonance detection of anti-cancer drug flutamide by graphitic carbon nitride/chitosan nanocomposite |
| title_full | Surface plasmon resonance detection of anti-cancer drug flutamide by graphitic carbon nitride/chitosan nanocomposite |
| title_fullStr | Surface plasmon resonance detection of anti-cancer drug flutamide by graphitic carbon nitride/chitosan nanocomposite |
| title_full_unstemmed | Surface plasmon resonance detection of anti-cancer drug flutamide by graphitic carbon nitride/chitosan nanocomposite |
| title_short | Surface plasmon resonance detection of anti-cancer drug flutamide by graphitic carbon nitride/chitosan nanocomposite |
| title_sort | surface plasmon resonance detection of anti cancer drug flutamide by graphitic carbon nitride chitosan nanocomposite |
| topic | SPR sensor Flutamide biosensor Graphitic-carbon nitrite-chitosan |
| url | https://doi.org/10.1038/s41598-025-86665-w |
| work_keys_str_mv | AT hassannasiri surfaceplasmonresonancedetectionofanticancerdrugflutamidebygraphiticcarbonnitridechitosannanocomposite AT karimabbasian surfaceplasmonresonancedetectionofanticancerdrugflutamidebygraphiticcarbonnitridechitosannanocomposite |