Solitary melanoma in the pineal gland: Differentiating primary from metastatic melanoma in the central nervous system
Primary melanoma of the pineal gland is exceedingly rare. Melanoma in the central nervous system (CNS) is far more likely to be a metastasis from a cutaneous primary; however, in a patient with no known history of melanoma, differentiating metastatic from primary CNS melanoma may present a diagnosti...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | Interdisciplinary Neurosurgery |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214751925000404 |
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| author | Denesh Selvarajah Hana Angelia Kawatu Peter Mews Elizabeth C Paver |
| author_facet | Denesh Selvarajah Hana Angelia Kawatu Peter Mews Elizabeth C Paver |
| author_sort | Denesh Selvarajah |
| collection | DOAJ |
| description | Primary melanoma of the pineal gland is exceedingly rare. Melanoma in the central nervous system (CNS) is far more likely to be a metastasis from a cutaneous primary; however, in a patient with no known history of melanoma, differentiating metastatic from primary CNS melanoma may present a diagnostic challenge. The distinction is important, however, as there are significant differences in tumour biology, prognosis, and responses to treatment. This report describes a rare case of solitary melanoma of the pineal gland in a 75-year-old female with no known history of melanoma and was considered as most likely to be a metastatic melanoma of unknown primary based on molecular testing of the tumour. This case highlights the utility of extended panel molecular testing in differentiating metastatic melanoma of unknown primary from primary CNS melanoma and the scarcity of evidence in the literature to guide the treatment in this setting. |
| format | Article |
| id | doaj-art-315031a7b17b4da3be99a2dab9db93fd |
| institution | OA Journals |
| issn | 2214-7519 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Interdisciplinary Neurosurgery |
| spelling | doaj-art-315031a7b17b4da3be99a2dab9db93fd2025-08-20T02:25:01ZengElsevierInterdisciplinary Neurosurgery2214-75192025-06-014010202810.1016/j.inat.2025.102028Solitary melanoma in the pineal gland: Differentiating primary from metastatic melanoma in the central nervous systemDenesh Selvarajah0Hana Angelia Kawatu1Peter Mews2Elizabeth C Paver3Neurosurgical Registrar, Department of Neurosurgery, The Canberra Hospital, Australia; Corresponding author.Anatomical Pathology Registrar, Department of Anatomical Pathology, The Canberra Hospital, AustraliaConsultant Neurosurgeon, Head of Department, Department of Neurosurgery, The Canberra Hospital, AustraliaConsultant Anatomical Pathologist, Department of Anatomical Pathology, The Canberra Hospital, Australian National University Medical School, ACT, AustraliaPrimary melanoma of the pineal gland is exceedingly rare. Melanoma in the central nervous system (CNS) is far more likely to be a metastasis from a cutaneous primary; however, in a patient with no known history of melanoma, differentiating metastatic from primary CNS melanoma may present a diagnostic challenge. The distinction is important, however, as there are significant differences in tumour biology, prognosis, and responses to treatment. This report describes a rare case of solitary melanoma of the pineal gland in a 75-year-old female with no known history of melanoma and was considered as most likely to be a metastatic melanoma of unknown primary based on molecular testing of the tumour. This case highlights the utility of extended panel molecular testing in differentiating metastatic melanoma of unknown primary from primary CNS melanoma and the scarcity of evidence in the literature to guide the treatment in this setting.http://www.sciencedirect.com/science/article/pii/S2214751925000404Primary CNS melanomaMeningeal melanomaPineal glandMetastatic melanoma |
| spellingShingle | Denesh Selvarajah Hana Angelia Kawatu Peter Mews Elizabeth C Paver Solitary melanoma in the pineal gland: Differentiating primary from metastatic melanoma in the central nervous system Interdisciplinary Neurosurgery Primary CNS melanoma Meningeal melanoma Pineal gland Metastatic melanoma |
| title | Solitary melanoma in the pineal gland: Differentiating primary from metastatic melanoma in the central nervous system |
| title_full | Solitary melanoma in the pineal gland: Differentiating primary from metastatic melanoma in the central nervous system |
| title_fullStr | Solitary melanoma in the pineal gland: Differentiating primary from metastatic melanoma in the central nervous system |
| title_full_unstemmed | Solitary melanoma in the pineal gland: Differentiating primary from metastatic melanoma in the central nervous system |
| title_short | Solitary melanoma in the pineal gland: Differentiating primary from metastatic melanoma in the central nervous system |
| title_sort | solitary melanoma in the pineal gland differentiating primary from metastatic melanoma in the central nervous system |
| topic | Primary CNS melanoma Meningeal melanoma Pineal gland Metastatic melanoma |
| url | http://www.sciencedirect.com/science/article/pii/S2214751925000404 |
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