Comparison of oscillatory activity in substantia nigra pars reticulata between Parkinson’s disease and dystonia
Abstract Parkinson’s disease (PD) is associated with disrupted neural activity in the substantia nigra, but its electrophysiological changes remain underexplored. This study investigates the oscillatory patterns of substantia nigra pars reticulata (SNr) in PD, compared to dystonia (DT). Intraoperati...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-05-01
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| Series: | npj Parkinson's Disease |
| Online Access: | https://doi.org/10.1038/s41531-025-00947-8 |
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| author | Lin Shi Yichen Xu Shiying Fan Zixiao Yin Guofan Qin Jianguo Zhang Anchao Yang |
| author_facet | Lin Shi Yichen Xu Shiying Fan Zixiao Yin Guofan Qin Jianguo Zhang Anchao Yang |
| author_sort | Lin Shi |
| collection | DOAJ |
| description | Abstract Parkinson’s disease (PD) is associated with disrupted neural activity in the substantia nigra, but its electrophysiological changes remain underexplored. This study investigates the oscillatory patterns of substantia nigra pars reticulata (SNr) in PD, compared to dystonia (DT). Intraoperative recordings of the SNr were obtained from 20 PD and 16 DT patients during DBS surgery. Spectral power, neuronal firing rate, beta burst dynamics, and correlation analysis of the SNr signal were analyzed. PD patients exhibited increased alpha and beta power, elevated firing rates, and reduced aperiodic exponent values in SNr compared to DT. PD beta bursts showed prolonged durations and fewer short bursts. Beta power negatively correlated with motor symptom improvement rates in PD but not in DT patients. These findings highlight pathological beta power in SNr of PD, which indicates that SNr-DBS may offer a future therapeutic avenue for PD. |
| format | Article |
| id | doaj-art-3147d299c58e43fd812814fad4e7407d |
| institution | OA Journals |
| issn | 2373-8057 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Parkinson's Disease |
| spelling | doaj-art-3147d299c58e43fd812814fad4e7407d2025-08-20T02:15:00ZengNature Portfolionpj Parkinson's Disease2373-80572025-05-011111910.1038/s41531-025-00947-8Comparison of oscillatory activity in substantia nigra pars reticulata between Parkinson’s disease and dystoniaLin Shi0Yichen Xu1Shiying Fan2Zixiao Yin3Guofan Qin4Jianguo Zhang5Anchao Yang6Department of Functional Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Functional Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Pediatric Surgery, Children’s Hospital, Capital Institute of PediatricsDepartment of Functional Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Functional Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Functional Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Functional Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityAbstract Parkinson’s disease (PD) is associated with disrupted neural activity in the substantia nigra, but its electrophysiological changes remain underexplored. This study investigates the oscillatory patterns of substantia nigra pars reticulata (SNr) in PD, compared to dystonia (DT). Intraoperative recordings of the SNr were obtained from 20 PD and 16 DT patients during DBS surgery. Spectral power, neuronal firing rate, beta burst dynamics, and correlation analysis of the SNr signal were analyzed. PD patients exhibited increased alpha and beta power, elevated firing rates, and reduced aperiodic exponent values in SNr compared to DT. PD beta bursts showed prolonged durations and fewer short bursts. Beta power negatively correlated with motor symptom improvement rates in PD but not in DT patients. These findings highlight pathological beta power in SNr of PD, which indicates that SNr-DBS may offer a future therapeutic avenue for PD.https://doi.org/10.1038/s41531-025-00947-8 |
| spellingShingle | Lin Shi Yichen Xu Shiying Fan Zixiao Yin Guofan Qin Jianguo Zhang Anchao Yang Comparison of oscillatory activity in substantia nigra pars reticulata between Parkinson’s disease and dystonia npj Parkinson's Disease |
| title | Comparison of oscillatory activity in substantia nigra pars reticulata between Parkinson’s disease and dystonia |
| title_full | Comparison of oscillatory activity in substantia nigra pars reticulata between Parkinson’s disease and dystonia |
| title_fullStr | Comparison of oscillatory activity in substantia nigra pars reticulata between Parkinson’s disease and dystonia |
| title_full_unstemmed | Comparison of oscillatory activity in substantia nigra pars reticulata between Parkinson’s disease and dystonia |
| title_short | Comparison of oscillatory activity in substantia nigra pars reticulata between Parkinson’s disease and dystonia |
| title_sort | comparison of oscillatory activity in substantia nigra pars reticulata between parkinson s disease and dystonia |
| url | https://doi.org/10.1038/s41531-025-00947-8 |
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