The apparent interferon resistance of transmitted HIV-1 is possibly a consequence of enhanced replicative fitness.

The apparent interferon resistance of transmitted HIV-1 is possibly a consequence of enhanced replicative fitness.

HIV-1 transmission via sexual exposure is an inefficient process. When transmission does occur, newly infected individuals are colonized by the descendants of either a single virion or a very small number of establishing virions. These transmitted founder (TF) viruses are more interferon (IFN)-resis...

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Main Authors: Elena Sugrue, Arthur Wickenhagen, Nardus Mollentze, Muhamad Afiq Aziz, Vattipally B Sreenu, Sven Truxa, Lily Tong, Ana da Silva Filipe, David L Robertson, Joseph Hughes, Suzannah J Rihn, Sam J Wilson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-11-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1010973&type=printable
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