A dual-reporter LDLR system integrating fluorescence and luminescence for understanding LDLR regulation and facilitating drug discovery

A dual-reporter LDLR system integrating fluorescence and luminescence for understanding LDLR regulation and facilitating drug discovery

IntroductionThe low-density lipoprotein receptor (LDLR) is integral to cholesterol metabolism and cardiovascular health. Enhancing LDLR expression is a promising strategy for treating hyperlipidemia and reducing the risk of atherosclerosis. However, current LDLR reporter systems have limitations in...

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Bibliographic Details
Main Authors: Peng Jiao, Na Yang, Qianfeng Jia, Baozhen Fan, Ke Feng, Jian Yu, Shengtian Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Molecular Biosciences
Subjects:
LDLR
knock-in cell line
CRISPR/Cas9
EGFP
gaussia luciferase
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2025.1552085/full
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