Graves’ disease with hyperfunctioning thyroid nodule harboring thyroid carcinoma. Case report and literature review
According to the American Thyroid Association’s 2015 guidelines: “Since hyperfunctioning nodules rarely harbor malignancy, if one is found that corresponds to the nodule in question, no cytologic evaluation is necessary”. These findings are based on numerous studies proving the rareness of the combi...
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| Format: | Article |
| Language: | Russian |
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ABV-press
2020-02-01
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| Series: | Опухоли головы и шеи |
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| Online Access: | https://ogsh.abvpress.ru/jour/article/view/451 |
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| author | A. A. Kuprin V. Y. Malyuga I. V. Makedonskaya A. A. Melnikova |
| author_facet | A. A. Kuprin V. Y. Malyuga I. V. Makedonskaya A. A. Melnikova |
| author_sort | A. A. Kuprin |
| collection | DOAJ |
| description | According to the American Thyroid Association’s 2015 guidelines: “Since hyperfunctioning nodules rarely harbor malignancy, if one is found that corresponds to the nodule in question, no cytologic evaluation is necessary”. These findings are based on numerous studies proving the rareness of the combination of functional autonomy and thyroid cancer, and when such casuistry is detected, the non-aggressive course of the malignant process is observed.Rare revealing of malignant nodules functional autonomy can be attributed to several fundamental bases of non-medullary thyroid carcinoma pathogenesis. According to one of the hypotheses of carcinogenesis, dedifferentiation of thyrocytes occurs initially with the loss of the possibility of the sodium-iodine symporter synthesis, and later of the thyroid-stimulating hormone receptor synthesis by the cell, which reduces the hormone production by tumor cells. In addition, hyperthyroidism has a protective feature. It reduces the level of thyroid-stimulating hormone (which causes hypertrophy, hyperplasia of thyrocytes and has an antiapoptotic effect). This protective function is used in practice for suppressive therapy in the postoperative period, which reduces the progression, recurrence and mortality from thyroid cancer. The above circumstances prove the rareness of the clinical observation described below, which deserves additional attention and subsequent discussion. |
| format | Article |
| id | doaj-art-312a62037c4e4498a1ea3496399e09f2 |
| institution | Kabale University |
| issn | 2222-1468 2411-4634 |
| language | Russian |
| publishDate | 2020-02-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Опухоли головы и шеи |
| spelling | doaj-art-312a62037c4e4498a1ea3496399e09f22025-08-20T03:37:09ZrusABV-pressОпухоли головы и шеи2222-14682411-46342020-02-0194627310.17650/2222-1468-2019-9-4-62-73374Graves’ disease with hyperfunctioning thyroid nodule harboring thyroid carcinoma. Case report and literature reviewA. A. Kuprin0V. Y. Malyuga1I. V. Makedonskaya2A. A. Melnikova3A.K. Eramishantsev City Clinical Hospital, Moscow Healthcare DepartmentRussian Clinical and Research Center of Gerontology, N. I. Pirogov Russian National Research Medical UniversityA.K. Eramishantsev City Clinical Hospital, Moscow Healthcare DepartmentA.K. Eramishantsev City Clinical Hospital, Moscow Healthcare DepartmentAccording to the American Thyroid Association’s 2015 guidelines: “Since hyperfunctioning nodules rarely harbor malignancy, if one is found that corresponds to the nodule in question, no cytologic evaluation is necessary”. These findings are based on numerous studies proving the rareness of the combination of functional autonomy and thyroid cancer, and when such casuistry is detected, the non-aggressive course of the malignant process is observed.Rare revealing of malignant nodules functional autonomy can be attributed to several fundamental bases of non-medullary thyroid carcinoma pathogenesis. According to one of the hypotheses of carcinogenesis, dedifferentiation of thyrocytes occurs initially with the loss of the possibility of the sodium-iodine symporter synthesis, and later of the thyroid-stimulating hormone receptor synthesis by the cell, which reduces the hormone production by tumor cells. In addition, hyperthyroidism has a protective feature. It reduces the level of thyroid-stimulating hormone (which causes hypertrophy, hyperplasia of thyrocytes and has an antiapoptotic effect). This protective function is used in practice for suppressive therapy in the postoperative period, which reduces the progression, recurrence and mortality from thyroid cancer. The above circumstances prove the rareness of the clinical observation described below, which deserves additional attention and subsequent discussion.https://ogsh.abvpress.ru/jour/article/view/451thyroid cancerhyperthyroidismgraves’ diseasefunctional autonomy of thyroid gland |
| spellingShingle | A. A. Kuprin V. Y. Malyuga I. V. Makedonskaya A. A. Melnikova Graves’ disease with hyperfunctioning thyroid nodule harboring thyroid carcinoma. Case report and literature review Опухоли головы и шеи thyroid cancer hyperthyroidism graves’ disease functional autonomy of thyroid gland |
| title | Graves’ disease with hyperfunctioning thyroid nodule harboring thyroid carcinoma. Case report and literature review |
| title_full | Graves’ disease with hyperfunctioning thyroid nodule harboring thyroid carcinoma. Case report and literature review |
| title_fullStr | Graves’ disease with hyperfunctioning thyroid nodule harboring thyroid carcinoma. Case report and literature review |
| title_full_unstemmed | Graves’ disease with hyperfunctioning thyroid nodule harboring thyroid carcinoma. Case report and literature review |
| title_short | Graves’ disease with hyperfunctioning thyroid nodule harboring thyroid carcinoma. Case report and literature review |
| title_sort | graves disease with hyperfunctioning thyroid nodule harboring thyroid carcinoma case report and literature review |
| topic | thyroid cancer hyperthyroidism graves’ disease functional autonomy of thyroid gland |
| url | https://ogsh.abvpress.ru/jour/article/view/451 |
| work_keys_str_mv | AT aakuprin gravesdiseasewithhyperfunctioningthyroidnoduleharboringthyroidcarcinomacasereportandliteraturereview AT vymalyuga gravesdiseasewithhyperfunctioningthyroidnoduleharboringthyroidcarcinomacasereportandliteraturereview AT ivmakedonskaya gravesdiseasewithhyperfunctioningthyroidnoduleharboringthyroidcarcinomacasereportandliteraturereview AT aamelnikova gravesdiseasewithhyperfunctioningthyroidnoduleharboringthyroidcarcinomacasereportandliteraturereview |