Immunomodulatory role of spleen tyrosine kinase in chronic inflammatory and autoimmune diseases
Abstract Background The high prevalence of chronic inflammatory diseases or autoimmune reactions is a major source of concern and affects the quality of life of patients. Chronic inflammatory or autoimmune diseases are associated with many diseases in humans, including asthma, rheumatoid arthritis,...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-07-01
|
| Series: | Immunity, Inflammation and Disease |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/iid3.934 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849254085479366656 |
|---|---|
| author | Yaqi Zhou Yaowen Zhang Wei Yu Yufen Qin Heng He Fengxian Dai Yibo Wang Fengqin Zhu Guangxi Zhou |
| author_facet | Yaqi Zhou Yaowen Zhang Wei Yu Yufen Qin Heng He Fengxian Dai Yibo Wang Fengqin Zhu Guangxi Zhou |
| author_sort | Yaqi Zhou |
| collection | DOAJ |
| description | Abstract Background The high prevalence of chronic inflammatory diseases or autoimmune reactions is a major source of concern and affects the quality of life of patients. Chronic inflammatory or autoimmune diseases are associated with many diseases in humans, including asthma, rheumatoid arthritis, systemic lupus erythematosus, inflammatory bowel disease and cancer. Splenic tyrosine kinase (SYK) is a non–receptor tyrosine kinase that plays an important role in immune receptor signalling in immune and inflammatory responses. Methods This is a review article in which we searched for keywords “splenic tyrosine kinase”, “inflammation” and “autoimmune diseases” in published literature such as Pubmed and Web of Science to collect relevant information and then conducted a study focusing on the latest findings on the involvement of SYK in chronic inflammatory or autoimmune diseases. Results This paper reviews the regulation of Fcγ, NF–κB, B cell and T cell–related signalling pathways by SYK, which contributes to disease progression in chronic inflammatory and autoimmune diseases such as airway fibrosis, inflammatory skin disease and inflammatory bowel disease. Conclusion This paper shows that SYK plays an important role in chronic inflammatory and autoimmune diseases. syk targets hematological, autoimmune and other inflammatory diseases and therefore, inhibition of SYK expression or blocking its related pathways may provide new ideas for clinical prevention and treatment of inflammatory or autoimmune diseases. |
| format | Article |
| id | doaj-art-3123b45ec65e49d0813ed3d7f499aee8 |
| institution | Kabale University |
| issn | 2050-4527 |
| language | English |
| publishDate | 2023-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Immunity, Inflammation and Disease |
| spelling | doaj-art-3123b45ec65e49d0813ed3d7f499aee82025-08-20T03:56:09ZengWileyImmunity, Inflammation and Disease2050-45272023-07-01117n/an/a10.1002/iid3.934Immunomodulatory role of spleen tyrosine kinase in chronic inflammatory and autoimmune diseasesYaqi Zhou0Yaowen Zhang1Wei Yu2Yufen Qin3Heng He4Fengxian Dai5Yibo Wang6Fengqin Zhu7Guangxi Zhou8Department of Clinical Medicine Jining Medical University Jining Shandong ChinaDepartment of Gastroenterology Affiliated Hospital of Jining Medical University, Jining Medical University Jining Shandong ChinaDepartment of Gastroenterology Affiliated Hospital of Jining Medical University, Jining Medical University Jining Shandong ChinaDepartment of Gastroenterology Affiliated Hospital of Jining Medical University, Jining Medical University Jining Shandong ChinaDepartment of Gastroenterology Affiliated Hospital of Jining Medical University, Jining Medical University Jining Shandong ChinaDepartment of Gastroenterology Affiliated Hospital of Jining Medical University, Jining Medical University Jining Shandong ChinaDepartment of Gastroenterology Affiliated Hospital of Jining Medical University, Jining Medical University Jining Shandong ChinaDepartment of Gastroenterology Affiliated Hospital of Jining Medical University, Jining Medical University Jining Shandong ChinaDepartment of Gastroenterology Affiliated Hospital of Jining Medical University, Jining Medical University Jining Shandong ChinaAbstract Background The high prevalence of chronic inflammatory diseases or autoimmune reactions is a major source of concern and affects the quality of life of patients. Chronic inflammatory or autoimmune diseases are associated with many diseases in humans, including asthma, rheumatoid arthritis, systemic lupus erythematosus, inflammatory bowel disease and cancer. Splenic tyrosine kinase (SYK) is a non–receptor tyrosine kinase that plays an important role in immune receptor signalling in immune and inflammatory responses. Methods This is a review article in which we searched for keywords “splenic tyrosine kinase”, “inflammation” and “autoimmune diseases” in published literature such as Pubmed and Web of Science to collect relevant information and then conducted a study focusing on the latest findings on the involvement of SYK in chronic inflammatory or autoimmune diseases. Results This paper reviews the regulation of Fcγ, NF–κB, B cell and T cell–related signalling pathways by SYK, which contributes to disease progression in chronic inflammatory and autoimmune diseases such as airway fibrosis, inflammatory skin disease and inflammatory bowel disease. Conclusion This paper shows that SYK plays an important role in chronic inflammatory and autoimmune diseases. syk targets hematological, autoimmune and other inflammatory diseases and therefore, inhibition of SYK expression or blocking its related pathways may provide new ideas for clinical prevention and treatment of inflammatory or autoimmune diseases.https://doi.org/10.1002/iid3.934autoimmune diseasechronic inflammationsignaling pathwayspleen tyrosine kinase |
| spellingShingle | Yaqi Zhou Yaowen Zhang Wei Yu Yufen Qin Heng He Fengxian Dai Yibo Wang Fengqin Zhu Guangxi Zhou Immunomodulatory role of spleen tyrosine kinase in chronic inflammatory and autoimmune diseases Immunity, Inflammation and Disease autoimmune disease chronic inflammation signaling pathway spleen tyrosine kinase |
| title | Immunomodulatory role of spleen tyrosine kinase in chronic inflammatory and autoimmune diseases |
| title_full | Immunomodulatory role of spleen tyrosine kinase in chronic inflammatory and autoimmune diseases |
| title_fullStr | Immunomodulatory role of spleen tyrosine kinase in chronic inflammatory and autoimmune diseases |
| title_full_unstemmed | Immunomodulatory role of spleen tyrosine kinase in chronic inflammatory and autoimmune diseases |
| title_short | Immunomodulatory role of spleen tyrosine kinase in chronic inflammatory and autoimmune diseases |
| title_sort | immunomodulatory role of spleen tyrosine kinase in chronic inflammatory and autoimmune diseases |
| topic | autoimmune disease chronic inflammation signaling pathway spleen tyrosine kinase |
| url | https://doi.org/10.1002/iid3.934 |
| work_keys_str_mv | AT yaqizhou immunomodulatoryroleofspleentyrosinekinaseinchronicinflammatoryandautoimmunediseases AT yaowenzhang immunomodulatoryroleofspleentyrosinekinaseinchronicinflammatoryandautoimmunediseases AT weiyu immunomodulatoryroleofspleentyrosinekinaseinchronicinflammatoryandautoimmunediseases AT yufenqin immunomodulatoryroleofspleentyrosinekinaseinchronicinflammatoryandautoimmunediseases AT henghe immunomodulatoryroleofspleentyrosinekinaseinchronicinflammatoryandautoimmunediseases AT fengxiandai immunomodulatoryroleofspleentyrosinekinaseinchronicinflammatoryandautoimmunediseases AT yibowang immunomodulatoryroleofspleentyrosinekinaseinchronicinflammatoryandautoimmunediseases AT fengqinzhu immunomodulatoryroleofspleentyrosinekinaseinchronicinflammatoryandautoimmunediseases AT guangxizhou immunomodulatoryroleofspleentyrosinekinaseinchronicinflammatoryandautoimmunediseases |