Assessing the impact of long-term inhaled corticosteroid therapy on patients with COVID-19 and coexisting chronic lung disease: A multicenter retrospective cohort study
# Background Patients with chronic lung disease (CLD), such as asthma or chronic obstructive pulmonary disease, were expected to have an increased risk of clinical manifestations and severity of COVID-19. However, these comorbidities have been reported less frequently than expected. Chronic treatme...
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| Format: | Article |
| Language: | English |
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Canadian Society of Respiratory Therapists
2024-06-01
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| Series: | Canadian Journal of Respiratory Therapy |
| Online Access: | https://doi.org/10.29390/001c.118514 |
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| author | Adela Pina Belmonte Manuel Madrazo Laura Piles Manuel Rubio-Rivas Lucía de Jorge Huerta María Gómez Antúnez Juan Francisco López Caleya Francisco Arnalich Fernández Martin Gericó-Aseguinolaza Paula Maria Pesqueira Fontan Nicolás Rhyman Marina Prieto Dehesa Juan Luis Romero Cabrera Gema María García García Gonzalo García-Casasola Ane Labirua-Iturburu Ruiz Francisco Javier Carrasco-Sánchez Sara Martínez Hernández Maria de los Reyes Pascual Pérez José López Castro José Luis Serrano Carrillo de Albornoz José F. Varona Ricardo Gómez-Huelgas Juan-Miguel Antón-Santos Carlos Lumbreras-Bermejo |
| author_facet | Adela Pina Belmonte Manuel Madrazo Laura Piles Manuel Rubio-Rivas Lucía de Jorge Huerta María Gómez Antúnez Juan Francisco López Caleya Francisco Arnalich Fernández Martin Gericó-Aseguinolaza Paula Maria Pesqueira Fontan Nicolás Rhyman Marina Prieto Dehesa Juan Luis Romero Cabrera Gema María García García Gonzalo García-Casasola Ane Labirua-Iturburu Ruiz Francisco Javier Carrasco-Sánchez Sara Martínez Hernández Maria de los Reyes Pascual Pérez José López Castro José Luis Serrano Carrillo de Albornoz José F. Varona Ricardo Gómez-Huelgas Juan-Miguel Antón-Santos Carlos Lumbreras-Bermejo |
| author_sort | Adela Pina Belmonte |
| collection | DOAJ |
| description | # Background
Patients with chronic lung disease (CLD), such as asthma or chronic obstructive pulmonary disease, were expected to have an increased risk of clinical manifestations and severity of COVID-19. However, these comorbidities have been reported less frequently than expected. Chronic treatment with inhaled corticosteroids (ICS) may impact the clinical course of COVID-19. The main objective of this study is to know the influence of chronic treatment with ICS on the prognosis of COVID-19 hospitalized patients with CLD.
# Methods
A multicenter retrospective cohort study was designed, including patients hospitalized with COVID-19. Epidemiological and clinical data were collected at admission and at seven days, and clinical outcomes were collected. Patients with CLD with and without chronic treatment with ICS were compared.
# Results
Two thousand five hundred ninety-eight patients were included, of which 1,171 patients had a diagnosis of asthma and 1,427 of COPD (53.37% and 41.41% with ICS, respectively). No differences were found in mortality, transfer to ICU, or development of moderate-severe ARDS. Patients with chronic ICS had a longer hospital stay in both asthma and COPD patients (9 vs. 8 days, *p =* 0.031 in asthma patients), (11 vs. 9 days, *p =* 0.018 in COPD patients); although they also had more comorbidity burden.
# Conclusions
Patients with chronic inhaled corticosteroids had longer hospital stays and more chronic comorbidities, measured by the Charlson comorbidity index, but they did not have more severe disease at admission, evaluated with qSOFA and PSI scores. Chronic treatment with inhaled corticosteroids had no influence on the prognosis of patients with chronic lung disease and COVID-19. |
| format | Article |
| id | doaj-art-31238611bc0a4318a294cc8077238a9f |
| institution | Kabale University |
| issn | 2368-6820 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | Canadian Society of Respiratory Therapists |
| record_format | Article |
| series | Canadian Journal of Respiratory Therapy |
| spelling | doaj-art-31238611bc0a4318a294cc8077238a9f2025-02-11T20:30:53ZengCanadian Society of Respiratory TherapistsCanadian Journal of Respiratory Therapy2368-68202024-06-0160Assessing the impact of long-term inhaled corticosteroid therapy on patients with COVID-19 and coexisting chronic lung disease: A multicenter retrospective cohort studyAdela Pina BelmonteManuel MadrazoLaura PilesManuel Rubio-RivasLucía de Jorge HuertaMaría Gómez AntúnezJuan Francisco López CaleyaFrancisco Arnalich FernándezMartin Gericó-AseguinolazaPaula Maria Pesqueira FontanNicolás RhymanMarina Prieto DehesaJuan Luis Romero CabreraGema María García GarcíaGonzalo García-CasasolaAne Labirua-Iturburu RuizFrancisco Javier Carrasco-SánchezSara Martínez HernándezMaria de los Reyes Pascual PérezJosé López CastroJosé Luis Serrano Carrillo de AlbornozJosé F. VaronaRicardo Gómez-HuelgasJuan-Miguel Antón-SantosCarlos Lumbreras-Bermejo# Background Patients with chronic lung disease (CLD), such as asthma or chronic obstructive pulmonary disease, were expected to have an increased risk of clinical manifestations and severity of COVID-19. However, these comorbidities have been reported less frequently than expected. Chronic treatment with inhaled corticosteroids (ICS) may impact the clinical course of COVID-19. The main objective of this study is to know the influence of chronic treatment with ICS on the prognosis of COVID-19 hospitalized patients with CLD. # Methods A multicenter retrospective cohort study was designed, including patients hospitalized with COVID-19. Epidemiological and clinical data were collected at admission and at seven days, and clinical outcomes were collected. Patients with CLD with and without chronic treatment with ICS were compared. # Results Two thousand five hundred ninety-eight patients were included, of which 1,171 patients had a diagnosis of asthma and 1,427 of COPD (53.37% and 41.41% with ICS, respectively). No differences were found in mortality, transfer to ICU, or development of moderate-severe ARDS. Patients with chronic ICS had a longer hospital stay in both asthma and COPD patients (9 vs. 8 days, *p =* 0.031 in asthma patients), (11 vs. 9 days, *p =* 0.018 in COPD patients); although they also had more comorbidity burden. # Conclusions Patients with chronic inhaled corticosteroids had longer hospital stays and more chronic comorbidities, measured by the Charlson comorbidity index, but they did not have more severe disease at admission, evaluated with qSOFA and PSI scores. Chronic treatment with inhaled corticosteroids had no influence on the prognosis of patients with chronic lung disease and COVID-19.https://doi.org/10.29390/001c.118514 |
| spellingShingle | Adela Pina Belmonte Manuel Madrazo Laura Piles Manuel Rubio-Rivas Lucía de Jorge Huerta María Gómez Antúnez Juan Francisco López Caleya Francisco Arnalich Fernández Martin Gericó-Aseguinolaza Paula Maria Pesqueira Fontan Nicolás Rhyman Marina Prieto Dehesa Juan Luis Romero Cabrera Gema María García García Gonzalo García-Casasola Ane Labirua-Iturburu Ruiz Francisco Javier Carrasco-Sánchez Sara Martínez Hernández Maria de los Reyes Pascual Pérez José López Castro José Luis Serrano Carrillo de Albornoz José F. Varona Ricardo Gómez-Huelgas Juan-Miguel Antón-Santos Carlos Lumbreras-Bermejo Assessing the impact of long-term inhaled corticosteroid therapy on patients with COVID-19 and coexisting chronic lung disease: A multicenter retrospective cohort study Canadian Journal of Respiratory Therapy |
| title | Assessing the impact of long-term inhaled corticosteroid therapy on patients with COVID-19 and coexisting chronic lung disease: A multicenter retrospective cohort study |
| title_full | Assessing the impact of long-term inhaled corticosteroid therapy on patients with COVID-19 and coexisting chronic lung disease: A multicenter retrospective cohort study |
| title_fullStr | Assessing the impact of long-term inhaled corticosteroid therapy on patients with COVID-19 and coexisting chronic lung disease: A multicenter retrospective cohort study |
| title_full_unstemmed | Assessing the impact of long-term inhaled corticosteroid therapy on patients with COVID-19 and coexisting chronic lung disease: A multicenter retrospective cohort study |
| title_short | Assessing the impact of long-term inhaled corticosteroid therapy on patients with COVID-19 and coexisting chronic lung disease: A multicenter retrospective cohort study |
| title_sort | assessing the impact of long term inhaled corticosteroid therapy on patients with covid 19 and coexisting chronic lung disease a multicenter retrospective cohort study |
| url | https://doi.org/10.29390/001c.118514 |
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