Histological and Morphometric Analysis with Grading of Atherosclerosis-Associated Myocardial Changes in Cases of Sudden Death at a Tertiary Care Hospital
Background: Sudden cardiac death (SCD) remains a significant public health concern worldwide, representing a considerable proportion of mortality linked to cardiovascular diseases. Atherosclerosis, a progressive disease characterized by the accumulation of lipids, fibrous elements, and inflammatory...
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Medsci Publications
2025-07-01
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| author | Prathana Patel Smita Jhaveri Parth Patel |
| author_facet | Prathana Patel Smita Jhaveri Parth Patel |
| author_sort | Prathana Patel |
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Background: Sudden cardiac death (SCD) remains a significant public health concern worldwide, representing a considerable proportion of mortality linked to cardiovascular diseases. Atherosclerosis, a progressive disease characterized by the accumulation of lipids, fibrous elements, and inflammatory cells within the arterial walls, is a leading underlying cause of SCD.
Methodology: An observational study was conducted focusing on histology, morphometric analysis, and grading of atherosclerosis-associated myocardial findings in cases of sudden death in 194 cases over a period of 18 months in the Department of Pathology, SMIMER Medical College, Surat.
Results: The study involved 194 participants, with a notable gender imbalance favouring males, who represented 89.7% of the cohort. There was a clear trend of increasing coronary artery grade with advancing age. Ischemic Heart Disease (IHD) was the most prevalent myocardial finding, observed in 54.6% of the cases. 148 (76%) cases showed both the coronary involvement in patients with Ischaemic Heart Disease. For Ischemic Heart Disease (IHD), the AHA grades are predominantly VII (47.2%), V (21.7%), and VI (17.0%). As the coronary artery grade increases, there is a notable rise in both ITI and IMR values.
Conclusion: In conclusion, this study demonstrates that a comprehensive evaluation combining histological grading and morphometric analysis is crucial for a thorough understanding of atherosclerosis-related myocardial changes.
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| format | Article |
| id | doaj-art-311f6af03b684dbda0f26cce233eab92 |
| institution | Kabale University |
| issn | 2249-4995 2277-8810 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Medsci Publications |
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| series | National Journal of Medical Research |
| spelling | doaj-art-311f6af03b684dbda0f26cce233eab922025-08-20T03:28:22ZengMedsci PublicationsNational Journal of Medical Research2249-49952277-88102025-07-01150310.55489/njmr.150320251125Histological and Morphometric Analysis with Grading of Atherosclerosis-Associated Myocardial Changes in Cases of Sudden Death at a Tertiary Care HospitalPrathana Patel0Smita Jhaveri1Parth Patel2Department of Pathology, SMIMER, Surat, IndiaDepartment of Pathology, SMIMER, Surat, IndiaDepartment of Pathology, SMIMER, Surat, India Background: Sudden cardiac death (SCD) remains a significant public health concern worldwide, representing a considerable proportion of mortality linked to cardiovascular diseases. Atherosclerosis, a progressive disease characterized by the accumulation of lipids, fibrous elements, and inflammatory cells within the arterial walls, is a leading underlying cause of SCD. Methodology: An observational study was conducted focusing on histology, morphometric analysis, and grading of atherosclerosis-associated myocardial findings in cases of sudden death in 194 cases over a period of 18 months in the Department of Pathology, SMIMER Medical College, Surat. Results: The study involved 194 participants, with a notable gender imbalance favouring males, who represented 89.7% of the cohort. There was a clear trend of increasing coronary artery grade with advancing age. Ischemic Heart Disease (IHD) was the most prevalent myocardial finding, observed in 54.6% of the cases. 148 (76%) cases showed both the coronary involvement in patients with Ischaemic Heart Disease. For Ischemic Heart Disease (IHD), the AHA grades are predominantly VII (47.2%), V (21.7%), and VI (17.0%). As the coronary artery grade increases, there is a notable rise in both ITI and IMR values. Conclusion: In conclusion, this study demonstrates that a comprehensive evaluation combining histological grading and morphometric analysis is crucial for a thorough understanding of atherosclerosis-related myocardial changes. https://njmr.in/index.php/file/article/view/1125Coronary AtherosclerosisSudden DeathIschaemic Heart DiseaseIntima Media RatioIntimal Thickness Index |
| spellingShingle | Prathana Patel Smita Jhaveri Parth Patel Histological and Morphometric Analysis with Grading of Atherosclerosis-Associated Myocardial Changes in Cases of Sudden Death at a Tertiary Care Hospital National Journal of Medical Research Coronary Atherosclerosis Sudden Death Ischaemic Heart Disease Intima Media Ratio Intimal Thickness Index |
| title | Histological and Morphometric Analysis with Grading of Atherosclerosis-Associated Myocardial Changes in Cases of Sudden Death at a Tertiary Care Hospital |
| title_full | Histological and Morphometric Analysis with Grading of Atherosclerosis-Associated Myocardial Changes in Cases of Sudden Death at a Tertiary Care Hospital |
| title_fullStr | Histological and Morphometric Analysis with Grading of Atherosclerosis-Associated Myocardial Changes in Cases of Sudden Death at a Tertiary Care Hospital |
| title_full_unstemmed | Histological and Morphometric Analysis with Grading of Atherosclerosis-Associated Myocardial Changes in Cases of Sudden Death at a Tertiary Care Hospital |
| title_short | Histological and Morphometric Analysis with Grading of Atherosclerosis-Associated Myocardial Changes in Cases of Sudden Death at a Tertiary Care Hospital |
| title_sort | histological and morphometric analysis with grading of atherosclerosis associated myocardial changes in cases of sudden death at a tertiary care hospital |
| topic | Coronary Atherosclerosis Sudden Death Ischaemic Heart Disease Intima Media Ratio Intimal Thickness Index |
| url | https://njmr.in/index.php/file/article/view/1125 |
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