Identification of 3-[(4-Acetylphenyl)(4-Phenylthiazol-2-Yl)Amino]Propanoic Acid Derivatives as Promising Scaffolds for the Development of Novel Anticancer Candidates Targeting SIRT2 and EGFR

Identification of 3-[(4-Acetylphenyl)(4-Phenylthiazol-2-Yl)Amino]Propanoic Acid Derivatives as Promising Scaffolds for the Development of Novel Anticancer Candidates Targeting SIRT2 and EGFR

<b>Background:</b> A series of novel polysubstituted thiazole derivatives were synthesized, and their antiproliferative properties were evaluated using both 2D and 3D lung cancer models. <b>Methods:</b> The compounds were obtained via esterification, oximation, hydrazinolysis...

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Main Authors: Božena Golcienė, Povilas Kavaliauskas, Waldo Acevedo, Birutė Sapijanskaitė-Banevič, Birutė Grybaitė, Ramunė Grigalevičiūtė, Rūta Petraitienė, Vidmantas Petraitis, Vytautas Mickevičius
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Pharmaceuticals
Subjects:
aminothiazoles
bisthiazolylphenylmethanes
hydrazones
hydrazides
oximes
anticancer properties
Online Access:https://www.mdpi.com/1424-8247/18/5/733
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