Associations between cerebral blood flow and progression of white matter hyperintensities
IntroductionIn an aging population, white matter hyperintensities (WMHs), observed on FLAIR MRI sequences, are indicators of cognitive decline, motor impairment, and increased vascular risk. However, the pathophysiological mechanisms underlying WMHs, including dynamic changes in cerebral blood flow...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Neuroimaging |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnimg.2024.1463311/full |
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| author | Siriluk Thammasart Danielle J. Harvey Pauline Maillard Charles DeCarli Corinne A. Donnay Gregory J. Wheeler Audrey P. Fan Audrey P. Fan |
| author_facet | Siriluk Thammasart Danielle J. Harvey Pauline Maillard Charles DeCarli Corinne A. Donnay Gregory J. Wheeler Audrey P. Fan Audrey P. Fan |
| author_sort | Siriluk Thammasart |
| collection | DOAJ |
| description | IntroductionIn an aging population, white matter hyperintensities (WMHs), observed on FLAIR MRI sequences, are indicators of cognitive decline, motor impairment, and increased vascular risk. However, the pathophysiological mechanisms underlying WMHs, including dynamic changes in cerebral blood flow (CBF) within and adjacent to lesions, remain poorly understood.MethodsOur study examined a diverse cohort of 300 elderly participants through arterial spin labeling (ASL) on 3 Tesla MRI, analyzing both cross-sectional and longitudinal data. We characterized the relationship between CBF and WMH development in different lesion locations (based on distance from ventricles) and brain tissue types (WMH lesion, penumbra, and normal white matter).ResultsOur findings reveal that WMHs exhibit significantly lower relative CBF (rCBF) compared to penumbra, normal-appearing white matter, and gray matter, with juxtaventricular WMHs (JVWMH) displaying the most substantial reductions. Longitudinally, WMHs that increased in size over a two-year period had lower baseline rCBF than those that remained stagnant, particularly in juxtaventricular and periventricular regions.DiscussionThis study not only highlights the predictive value of rCBF in WMH progression but also provides location-specific hemodynamic information about WMHs that can guide clinical management of WMH-related brain changes and their clinical manifestations. |
| format | Article |
| id | doaj-art-311a3f33a90b4dc0b98a69c49c11566d |
| institution | Kabale University |
| issn | 2813-1193 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neuroimaging |
| spelling | doaj-art-311a3f33a90b4dc0b98a69c49c11566d2025-01-21T08:36:31ZengFrontiers Media S.A.Frontiers in Neuroimaging2813-11932025-01-01310.3389/fnimg.2024.14633111463311Associations between cerebral blood flow and progression of white matter hyperintensitiesSiriluk Thammasart0Danielle J. Harvey1Pauline Maillard2Charles DeCarli3Corinne A. Donnay4Gregory J. Wheeler5Audrey P. Fan6Audrey P. Fan7Biological Engineering Program, Faculty of Engineering, King Mongkut's University of Technology Thonburi, Bangkok, ThailandPublic Health Sciences, University of California Davis School of Medicine, Davis, CA, United StatesNeurology, University of California, Davis, Davis, CA, United StatesNeurology, University of California, Davis, Davis, CA, United StatesNeurology, University of California, Davis, Davis, CA, United StatesBiomedical Engineering, University of California, Davis, Davis, CA, United StatesNeurology, University of California, Davis, Davis, CA, United StatesBiomedical Engineering, University of California, Davis, Davis, CA, United StatesIntroductionIn an aging population, white matter hyperintensities (WMHs), observed on FLAIR MRI sequences, are indicators of cognitive decline, motor impairment, and increased vascular risk. However, the pathophysiological mechanisms underlying WMHs, including dynamic changes in cerebral blood flow (CBF) within and adjacent to lesions, remain poorly understood.MethodsOur study examined a diverse cohort of 300 elderly participants through arterial spin labeling (ASL) on 3 Tesla MRI, analyzing both cross-sectional and longitudinal data. We characterized the relationship between CBF and WMH development in different lesion locations (based on distance from ventricles) and brain tissue types (WMH lesion, penumbra, and normal white matter).ResultsOur findings reveal that WMHs exhibit significantly lower relative CBF (rCBF) compared to penumbra, normal-appearing white matter, and gray matter, with juxtaventricular WMHs (JVWMH) displaying the most substantial reductions. Longitudinally, WMHs that increased in size over a two-year period had lower baseline rCBF than those that remained stagnant, particularly in juxtaventricular and periventricular regions.DiscussionThis study not only highlights the predictive value of rCBF in WMH progression but also provides location-specific hemodynamic information about WMHs that can guide clinical management of WMH-related brain changes and their clinical manifestations.https://www.frontiersin.org/articles/10.3389/fnimg.2024.1463311/fullwhite matter hyperintensity (WMH)brain agingpenumbracerebral blood flow (CBF)arterial spin labeling (ASL)magnetic resonance imaging (MRI) |
| spellingShingle | Siriluk Thammasart Danielle J. Harvey Pauline Maillard Charles DeCarli Corinne A. Donnay Gregory J. Wheeler Audrey P. Fan Audrey P. Fan Associations between cerebral blood flow and progression of white matter hyperintensities Frontiers in Neuroimaging white matter hyperintensity (WMH) brain aging penumbra cerebral blood flow (CBF) arterial spin labeling (ASL) magnetic resonance imaging (MRI) |
| title | Associations between cerebral blood flow and progression of white matter hyperintensities |
| title_full | Associations between cerebral blood flow and progression of white matter hyperintensities |
| title_fullStr | Associations between cerebral blood flow and progression of white matter hyperintensities |
| title_full_unstemmed | Associations between cerebral blood flow and progression of white matter hyperintensities |
| title_short | Associations between cerebral blood flow and progression of white matter hyperintensities |
| title_sort | associations between cerebral blood flow and progression of white matter hyperintensities |
| topic | white matter hyperintensity (WMH) brain aging penumbra cerebral blood flow (CBF) arterial spin labeling (ASL) magnetic resonance imaging (MRI) |
| url | https://www.frontiersin.org/articles/10.3389/fnimg.2024.1463311/full |
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