Molecular Determinants of Protein Pathogenicity at the Single‐Aggregate Level

Molecular Determinants of Protein Pathogenicity at the Single‐Aggregate Level

Abstract Determining the structure‐function relationships of protein aggregates is a fundamental challenge in biology. These aggregates, whether formed in vitro, within cells, or in living organisms, present significant heterogeneity in their molecular features such as size, structure, and compositi...

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Main Authors: Agnieszka Urbanek, Emma F. Garland, Emily E. Prescott, Marianne C. King, Anna Olerinyova, Hollie E. Wareing, Nia Georgieva, Ellie L. Bradshaw, Svetomir B. Tzokov, Alexander Knight, Alexander I. Tartakovskii, Tarja Malm, J Robin Highley, Suman De
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:Advanced Science
Subjects:
neurodegenerative disease
protein aggregation
single‐molecule imaging
structure‐function relationship
Online Access:https://doi.org/10.1002/advs.202410229
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