Gen-miR-5 derived from Gentianella acuta inhibits PFKP to prevent fibroblast activation and alleviate myocardial fibrosis

Gen-miR-5 derived from Gentianella acuta inhibits PFKP to prevent fibroblast activation and alleviate myocardial fibrosis

IntroductionMyocardial fibrosis (MF) is a key pathological change in heart failure, and lactate a product of glycolysis, is an important component affecting the process of MF. miRNAs derived from Gentianella acuta (G. acuta) have been shown to effectively treat cardiac remodeling. However, whether G...

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Bibliographic Details
Main Authors: Hongyao Ge, Zhenyu Du, Weizhe Liu, Letian Wang, Junyang Li, Gaoshan Yang, Aiying Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Pharmacology
Subjects:
plant-derived miRNAs
PFKP
lactate
fibroblast activation
myocardial fibrosis
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1578877/full
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