AhR deficiency exacerbates inflammation in diabetic wounds via impaired mitophagy and cGAS-STING-NLRP3 activation: Therapeutic potential of hydrogels loaded with FICZ

AhR deficiency exacerbates inflammation in diabetic wounds via impaired mitophagy and cGAS-STING-NLRP3 activation: Therapeutic potential of hydrogels loaded with FICZ

Delayed healing of diabetic foot ulcers (DFUs) is driven by chronic inflammation and mitochondrial dysfunction. We identify the aryl hydrocarbon receptor (AhR) as a key regulator of immune and mitochondrial homeostasis in diabetic wounds. AhR expression was elevated in macrophages from human and mur...

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Bibliographic Details
Main Authors: Yingying Wang, Tianyi Ni, Qian Zhang, Zibo Xu, Zhechen Zhu, Jiaheng Xie, Min Yi, Liying Tu, Zexiong Cheng, Yiwen Gao, Haowen Xu, Wei Yan, Jingping Shi
Format: Article
Language:English
Published: Elsevier 2025-10-01
Series:Materials Today Bio
Subjects:
Aryl hydrocarbon receptor (AhR)
Macrophage polarization
Mitophagy
GelMA hydrogel
Online Access:http://www.sciencedirect.com/science/article/pii/S2590006425006891
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