Chronic Spontaneous Urticaria Cyclosporine Treatment: Our Experience
Aim:Treatment of severe chronic autoimmune urticaria is difficult. In this study we aimed to investigate efficacy and safety of cyclosporine in patients with chronic urticaria.Material and Method:Twenty patients with chronic spontaneous urticaria whom detailed physical exami-nation were noted and we...
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Galenos Publishing House
2016-08-01
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| Series: | Ankara Üniversitesi Tıp Fakültesi Mecmuas |
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| author | Hilayda Karakök Güngör Seçil Saral Ayșenur Maden Nihal Kundakçı Beyza Doğanay Erdoğan Bengü Nisa Akay |
| author_facet | Hilayda Karakök Güngör Seçil Saral Ayșenur Maden Nihal Kundakçı Beyza Doğanay Erdoğan Bengü Nisa Akay |
| author_sort | Hilayda Karakök Güngör |
| collection | DOAJ |
| description | Aim:Treatment of severe chronic autoimmune urticaria is difficult. In this study we aimed to investigate efficacy and safety of cyclosporine in patients with chronic urticaria.Material and Method:Twenty patients with chronic spontaneous urticaria whom detailed physical exami-nation were noted and were treated in our center between 2005 and 2013 were included in this study.Results:A total 20 patients were included in this study. Daily wheal number and number of angioedema at-tacks had been compared and significant reduce in both parameters were detected. Total duration of treat-ment was mean (min: 4, max: 144) 27,05 (±30,9507 SD, median 18) weeks. Daily cyclosporine dosages were (min: 0,54, max: 3,57), mean 2,2672 (±0,81441SD, median 2,1237). Mild hypertension was detected in two pati-ents under treatment and had been treated with anti hypertensive agents. Dyplopia was developed in 1 pati-ent. We observed elevated creatinine levels in 3 patients.Conclusion:A daily mean dosage of 2,2672 mg of cyclosporine is effective in treatment of chronic urticaria for a duration of 27 weeks. All patients must be followed up closely to monitore adverse events. Recurrence was seen in a mean 9 weeks after cessation of therapy. |
| format | Article |
| id | doaj-art-30fc44bbabc9450bb189de87de4a2d3b |
| institution | Kabale University |
| issn | 1307-5608 1307-5608 |
| language | English |
| publishDate | 2016-08-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Ankara Üniversitesi Tıp Fakültesi Mecmuas |
| spelling | doaj-art-30fc44bbabc9450bb189de87de4a2d3b2025-08-20T03:55:12ZengGalenos Publishing HouseAnkara Üniversitesi Tıp Fakültesi Mecmuas1307-56081307-56082016-08-0169210711010.1501/Tipfak_000000092713049054Chronic Spontaneous Urticaria Cyclosporine Treatment: Our ExperienceHilayda Karakök Güngör0Seçil Saral1Ayșenur Maden2Nihal Kundakçı3Beyza Doğanay Erdoğan4Bengü Nisa Akay5 Ankara Üniversitesi Tıp Fakültesi Deri ve Zührevi Hastalıklar Anabilim Dalı Ankara Üniversitesi Tıp Fakültesi Deri ve Zührevi Hastalıklar Anabilim Dalı Ankara Üniversitesi Tıp Fakültesi Deri ve Zührevi Hastalıklar Anabilim Dalı Ankara Üniversitesi Tıp Fakültesi Deri ve Zührevi Hastalıklar Anabilim Dalı Ankara Üniversitesi Tıp Fakültesi Biyoistatistik Anabilim Dalı Ankara Üniversitesi Tıp Fakültesi Deri ve Zührevi Hastalıklar Anabilim Dalı Aim:Treatment of severe chronic autoimmune urticaria is difficult. In this study we aimed to investigate efficacy and safety of cyclosporine in patients with chronic urticaria.Material and Method:Twenty patients with chronic spontaneous urticaria whom detailed physical exami-nation were noted and were treated in our center between 2005 and 2013 were included in this study.Results:A total 20 patients were included in this study. Daily wheal number and number of angioedema at-tacks had been compared and significant reduce in both parameters were detected. Total duration of treat-ment was mean (min: 4, max: 144) 27,05 (±30,9507 SD, median 18) weeks. Daily cyclosporine dosages were (min: 0,54, max: 3,57), mean 2,2672 (±0,81441SD, median 2,1237). Mild hypertension was detected in two pati-ents under treatment and had been treated with anti hypertensive agents. Dyplopia was developed in 1 pati-ent. We observed elevated creatinine levels in 3 patients.Conclusion:A daily mean dosage of 2,2672 mg of cyclosporine is effective in treatment of chronic urticaria for a duration of 27 weeks. All patients must be followed up closely to monitore adverse events. Recurrence was seen in a mean 9 weeks after cessation of therapy. http://ankaratipfakultesimecmuasi.net/archives/archive-detail/article-preview/chronic-spontaneous-urticaria-cyclosporine-treatme/18366 Chronic UrticariaCyclosporine |
| spellingShingle | Hilayda Karakök Güngör Seçil Saral Ayșenur Maden Nihal Kundakçı Beyza Doğanay Erdoğan Bengü Nisa Akay Chronic Spontaneous Urticaria Cyclosporine Treatment: Our Experience Ankara Üniversitesi Tıp Fakültesi Mecmuas Chronic Urticaria Cyclosporine |
| title | Chronic Spontaneous Urticaria Cyclosporine Treatment: Our Experience |
| title_full | Chronic Spontaneous Urticaria Cyclosporine Treatment: Our Experience |
| title_fullStr | Chronic Spontaneous Urticaria Cyclosporine Treatment: Our Experience |
| title_full_unstemmed | Chronic Spontaneous Urticaria Cyclosporine Treatment: Our Experience |
| title_short | Chronic Spontaneous Urticaria Cyclosporine Treatment: Our Experience |
| title_sort | chronic spontaneous urticaria cyclosporine treatment our experience |
| topic | Chronic Urticaria Cyclosporine |
| url |
http://ankaratipfakultesimecmuasi.net/archives/archive-detail/article-preview/chronic-spontaneous-urticaria-cyclosporine-treatme/18366
|
| work_keys_str_mv | AT hilaydakarakokgungor chronicspontaneousurticariacyclosporinetreatmentourexperience AT secilsaral chronicspontaneousurticariacyclosporinetreatmentourexperience AT aysenurmaden chronicspontaneousurticariacyclosporinetreatmentourexperience AT nihalkundakcı chronicspontaneousurticariacyclosporinetreatmentourexperience AT beyzadoganayerdogan chronicspontaneousurticariacyclosporinetreatmentourexperience AT bengunisaakay chronicspontaneousurticariacyclosporinetreatmentourexperience |