Immunomodulation effects of collagen hydrogel encapsulating extracellular vesicles derived from calcium silicate stimulated-adipose mesenchymal stem cells for diabetic healing

Immunomodulation effects of collagen hydrogel encapsulating extracellular vesicles derived from calcium silicate stimulated-adipose mesenchymal stem cells for diabetic healing

Abstract Diabetic wounds are characterized by chronic inflammation, reduced angiogenesis, and insufficient collagen deposition, leading to impaired healing. Extracellular vesicles (EVs) derived from adipose-derived mesenchymal stem cells (ADSC) offer a promising cell-free therapeutic strategy, yet t...

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Main Authors: Yen-Hong Lin, Yeh Chen, En-Wei Liu, Mei-Chih Chen, Min-Hua Yu, Cheng-Yu Chen, Chia-Che Ho, Tai-Yi Hsu-Jiang, Jian-Jr Lee, Der-Yang Cho, Ming-You Shie
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Journal of Nanobiotechnology
Subjects:
Extracellular vesicles
Calcium silicate
Immunomodulation
Diabetic wound healing
Online Access:https://doi.org/10.1186/s12951-025-03097-4
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