Sentinel lymph node biopsy for cutaneous melanoma: A 6 years study
Background: The aim of this study was to evaluate the results of sentinel lymph node biopsy (SLNB) in cutaneous melanoma at our institution. Materials and Methods: 128 patients with primary cutaneous melanoma who underwent SLNB between April, 2004, and August, 2010 were studied. Univariate and multi...
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Thieme Medical and Scientific Publishers Pvt. Ltd.
2013-01-01
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| Series: | Indian Journal of Plastic Surgery |
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| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.4103/0970-0358.113717 |
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| author | Jaime Lima Sánchez M. Sánchez Medina O. García Duque M. Fiúza Pérez G. Carretero Hernández J. Fernández Palácios |
| author_facet | Jaime Lima Sánchez M. Sánchez Medina O. García Duque M. Fiúza Pérez G. Carretero Hernández J. Fernández Palácios |
| author_sort | Jaime Lima Sánchez |
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| description | Background: The aim of this study was to evaluate the results of sentinel lymph node biopsy (SLNB) in cutaneous melanoma at our institution. Materials and Methods: 128 patients with primary cutaneous melanoma who underwent SLNB between April, 2004, and August, 2010 were studied. Univariate and multivariate analysis was performed to explore the effect of variables on mortality and sentinel node status. Survival analysis was performed using the Kaplan-Meier approach. Results: Positive SLNB were detected in 35 (27.3%) of 128 cases. Mean Breslow depths were 3.7 mm for SLNB positive patients and 1.99 mm for SLNB negative patients. False negative rate was 1%. The recurrence rate was 40% for positive patients and 6.5% for negative patients (odds ratio 9.7 [confidence interval 95 % 3.3-28.1]). 33 patients (29%) had an ulcerated melanoma, 12 (10.5%) in the positive group and 21 (18.5%) in the negative group. The disease recurred in a 48.5% of patients with ulcerated melanoma, but only in a 2.5% of patients with non-ulcerated melanoma. Upon multivariate analysis, only Breslow thickness (P = 0.005) demonstrate statistically significance for SLNB status. Multivariate analysis for clinicopathologic predictors of death demonstrate statistically significance for Breslow thickness (P = 0.020), ulceration (P = 0.030) and sentinel node status (P = 0.020). Conclusions: This study confirms that the status of the sentinel node is a strong independent prognostic factor with a higher risk of death and lower survival. Patients with ulcerated melanoma are more likely to develop recurrence, and also higher risk of death than patients with non-ulcerated melanoma. |
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| institution | OA Journals |
| issn | 0970-0358 1998-376X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
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| series | Indian Journal of Plastic Surgery |
| spelling | doaj-art-30f4ae77392b49338fc7a86fd227dcd12025-08-20T02:38:55ZengThieme Medical and Scientific Publishers Pvt. Ltd.Indian Journal of Plastic Surgery0970-03581998-376X2013-01-01460109209710.4103/0970-0358.113717Sentinel lymph node biopsy for cutaneous melanoma: A 6 years studyJaime Lima Sánchez0M. Sánchez Medina1O. García Duque2M. Fiúza Pérez3G. Carretero Hernández4J. Fernández Palácios5Department of Plastic, Reconstructive and Aesthetic Surgery, Universitary Hospital of Gran Canaria, Dr. Negrín, Las Palmas de Gran Canaria, SpainDepartment of Plastic, Reconstructive and Aesthetic Surgery, Universitary Hospital of Gran Canaria, Dr. Negrín, Las Palmas de Gran Canaria, SpainDepartment of Plastic, Reconstructive and Aesthetic Surgery, Universitary Hospital of Gran Canaria, Dr. Negrín, Las Palmas de Gran Canaria, SpainResearch Unit, Universitary Hospital of Gran Canaria, Dr. Negrín, Las Palmas de Gran Canaria, SpainDepartment of Dermatology, Universitary Hospital of Gran Canaria, Dr. Negrín, Las Palmas de Gran Canaria, SpainDepartment of Plastic, Reconstructive and Aesthetic Surgery, Universitary Hospital of Gran Canaria, Dr. Negrín, Las Palmas de Gran Canaria, SpainBackground: The aim of this study was to evaluate the results of sentinel lymph node biopsy (SLNB) in cutaneous melanoma at our institution. Materials and Methods: 128 patients with primary cutaneous melanoma who underwent SLNB between April, 2004, and August, 2010 were studied. Univariate and multivariate analysis was performed to explore the effect of variables on mortality and sentinel node status. Survival analysis was performed using the Kaplan-Meier approach. Results: Positive SLNB were detected in 35 (27.3%) of 128 cases. Mean Breslow depths were 3.7 mm for SLNB positive patients and 1.99 mm for SLNB negative patients. False negative rate was 1%. The recurrence rate was 40% for positive patients and 6.5% for negative patients (odds ratio 9.7 [confidence interval 95 % 3.3-28.1]). 33 patients (29%) had an ulcerated melanoma, 12 (10.5%) in the positive group and 21 (18.5%) in the negative group. The disease recurred in a 48.5% of patients with ulcerated melanoma, but only in a 2.5% of patients with non-ulcerated melanoma. Upon multivariate analysis, only Breslow thickness (P = 0.005) demonstrate statistically significance for SLNB status. Multivariate analysis for clinicopathologic predictors of death demonstrate statistically significance for Breslow thickness (P = 0.020), ulceration (P = 0.030) and sentinel node status (P = 0.020). Conclusions: This study confirms that the status of the sentinel node is a strong independent prognostic factor with a higher risk of death and lower survival. Patients with ulcerated melanoma are more likely to develop recurrence, and also higher risk of death than patients with non-ulcerated melanoma.http://www.thieme-connect.de/DOI/DOI?10.4103/0970-0358.113717melanomasentinel node biopsysentinel node dissection |
| spellingShingle | Jaime Lima Sánchez M. Sánchez Medina O. García Duque M. Fiúza Pérez G. Carretero Hernández J. Fernández Palácios Sentinel lymph node biopsy for cutaneous melanoma: A 6 years study Indian Journal of Plastic Surgery melanoma sentinel node biopsy sentinel node dissection |
| title | Sentinel lymph node biopsy for cutaneous melanoma: A 6 years study |
| title_full | Sentinel lymph node biopsy for cutaneous melanoma: A 6 years study |
| title_fullStr | Sentinel lymph node biopsy for cutaneous melanoma: A 6 years study |
| title_full_unstemmed | Sentinel lymph node biopsy for cutaneous melanoma: A 6 years study |
| title_short | Sentinel lymph node biopsy for cutaneous melanoma: A 6 years study |
| title_sort | sentinel lymph node biopsy for cutaneous melanoma a 6 years study |
| topic | melanoma sentinel node biopsy sentinel node dissection |
| url | http://www.thieme-connect.de/DOI/DOI?10.4103/0970-0358.113717 |
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