The limited immunomodulatory effects of escharectomy on the kinetics of endotoxin, cytokines, and adhesion molecules in major burns
ESCHARECTOMY has been shown to improve the survival rates and the outcomes in burns. This observational study was conducted to assess the role of escharectomy on the inflammatory mediators in major burns. Seventeen ASA physical status II or status III adult surviving major burn patients were recruit...
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| Format: | Article |
| Language: | English |
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Wiley
2004-01-01
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| Series: | Mediators of Inflammation |
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| Online Access: | http://dx.doi.org/10.1080/09629350400003191 |
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| author | Tae-Hyung Han Soo-Yeon Lee Jung-Eun Kwon In-Suk Kwak Kwang-Min Kim |
| author_facet | Tae-Hyung Han Soo-Yeon Lee Jung-Eun Kwon In-Suk Kwak Kwang-Min Kim |
| author_sort | Tae-Hyung Han |
| collection | DOAJ |
| description | ESCHARECTOMY has been shown to improve the survival rates and the outcomes in burns. This observational study was conducted to assess the role of escharectomy on the inflammatory mediators in major burns. Seventeen ASA physical status II or status III adult surviving major burn patients were recruited. When the escharectomy was scheduled, a series of blood samples was obtained at −3 and −1 days preoperation, and +1 and +3 postoperation. The changing levels of endotoxin, cytokines, and adhesion molecules were measured with a quantitative sandwich immunoassay. Extensive escharectomy did not appear to have any significant impact on the levels of tumor necrosis factor alpha, interleukin-10, soluble intracellular adhesion molecule-1 and soluble vascular adhesion molecule-1. Meanwhile, endotoxin and E-selectin were significantly decreased after escharectomy. Escharectomy appeared to have a limited immunomodulatory effect on the inflammatory mediators in systemic inflammatory responses induced by major burns. This is probably related to the timing and extent of surgery, and the complex nature of burn-related inflammation. |
| format | Article |
| id | doaj-art-30f1d679458541b99ef7a6912d2df657 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2004-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-30f1d679458541b99ef7a6912d2df6572025-02-03T05:57:42ZengWileyMediators of Inflammation0962-93511466-18612004-01-0113424124610.1080/09629350400003191The limited immunomodulatory effects of escharectomy on the kinetics of endotoxin, cytokines, and adhesion molecules in major burnsTae-Hyung Han0Soo-Yeon Lee1Jung-Eun Kwon2In-Suk Kwak3Kwang-Min Kim4Department of Anesthesiology and Pain Medicine, Hangang Sacred Heart Hospital Hallym University, College of Medicine, 94-200 Yongdungpo-Dong, Yongdungpo-Ku, Seoul 150-710, KoreaDepartment of Anesthesiology and Pain Medicine, Hangang Sacred Heart Hospital Hallym University, College of Medicine, 94-200 Yongdungpo-Dong, Yongdungpo-Ku, Seoul 150-710, KoreaDepartment of Anesthesiology and Pain Medicine, Hangang Sacred Heart Hospital Hallym University, College of Medicine, 94-200 Yongdungpo-Dong, Yongdungpo-Ku, Seoul 150-710, KoreaDepartment of Anesthesiology and Pain Medicine, Hangang Sacred Heart Hospital Hallym University, College of Medicine, 94-200 Yongdungpo-Dong, Yongdungpo-Ku, Seoul 150-710, KoreaDepartment of Anesthesiology and Pain Medicine, Hangang Sacred Heart Hospital Hallym University, College of Medicine, 94-200 Yongdungpo-Dong, Yongdungpo-Ku, Seoul 150-710, KoreaESCHARECTOMY has been shown to improve the survival rates and the outcomes in burns. This observational study was conducted to assess the role of escharectomy on the inflammatory mediators in major burns. Seventeen ASA physical status II or status III adult surviving major burn patients were recruited. When the escharectomy was scheduled, a series of blood samples was obtained at −3 and −1 days preoperation, and +1 and +3 postoperation. The changing levels of endotoxin, cytokines, and adhesion molecules were measured with a quantitative sandwich immunoassay. Extensive escharectomy did not appear to have any significant impact on the levels of tumor necrosis factor alpha, interleukin-10, soluble intracellular adhesion molecule-1 and soluble vascular adhesion molecule-1. Meanwhile, endotoxin and E-selectin were significantly decreased after escharectomy. Escharectomy appeared to have a limited immunomodulatory effect on the inflammatory mediators in systemic inflammatory responses induced by major burns. This is probably related to the timing and extent of surgery, and the complex nature of burn-related inflammation.http://dx.doi.org/10.1080/09629350400003191E-selectinInterleukin-10soluble intercellular adhesion molecule-1Thermal injuryTumor necrosis factor alphaSoluble vascular adhesion molecule-1Burn wound excision. |
| spellingShingle | Tae-Hyung Han Soo-Yeon Lee Jung-Eun Kwon In-Suk Kwak Kwang-Min Kim The limited immunomodulatory effects of escharectomy on the kinetics of endotoxin, cytokines, and adhesion molecules in major burns Mediators of Inflammation E-selectin Interleukin-10 soluble intercellular adhesion molecule-1 Thermal injury Tumor necrosis factor alpha Soluble vascular adhesion molecule-1 Burn wound excision. |
| title | The limited immunomodulatory effects of escharectomy on the kinetics of endotoxin, cytokines, and adhesion molecules in major burns |
| title_full | The limited immunomodulatory effects of escharectomy on the kinetics of endotoxin, cytokines, and adhesion molecules in major burns |
| title_fullStr | The limited immunomodulatory effects of escharectomy on the kinetics of endotoxin, cytokines, and adhesion molecules in major burns |
| title_full_unstemmed | The limited immunomodulatory effects of escharectomy on the kinetics of endotoxin, cytokines, and adhesion molecules in major burns |
| title_short | The limited immunomodulatory effects of escharectomy on the kinetics of endotoxin, cytokines, and adhesion molecules in major burns |
| title_sort | limited immunomodulatory effects of escharectomy on the kinetics of endotoxin cytokines and adhesion molecules in major burns |
| topic | E-selectin Interleukin-10 soluble intercellular adhesion molecule-1 Thermal injury Tumor necrosis factor alpha Soluble vascular adhesion molecule-1 Burn wound excision. |
| url | http://dx.doi.org/10.1080/09629350400003191 |
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