EFFECT OF HYDROGEN SULFIDE ON ATRIUM CONTRACTILITY IN CONTROL AND DIABETHIC MICE
Hydrogen sulfide (H2S) is endogenously synthesized gasotransmitter that has a regulatory effect in cardiovascular system. Diabetes mellitus leads to an increased risk of hypertension and cardiovascular diseases, so the purpose of the study was to analyze the contractility of the atria mice after app...
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| Format: | Article |
| Language: | English |
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Siberian State Medical University (Tomsk)
2014-12-01
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| Series: | Бюллетень сибирской медицины |
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| Online Access: | https://bulletin.ssmu.ru/jour/article/view/165 |
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| author | A. S. Lifanova O. V. Yakovleva A. I. Zefirov G. F. Sitdikova |
| author_facet | A. S. Lifanova O. V. Yakovleva A. I. Zefirov G. F. Sitdikova |
| author_sort | A. S. Lifanova |
| collection | DOAJ |
| description | Hydrogen sulfide (H2S) is endogenously synthesized gasotransmitter that has a regulatory effect in cardiovascular system. Diabetes mellitus leads to an increased risk of hypertension and cardiovascular diseases, so the purpose of the study was to analyze the contractility of the atria mice after application of L-cysteine and H2S. Contractile activity of the myocardium was investigated in the experiment on isolated mouse atria. Alloxan was used for modeling diabetes. Intraperitoneal injection of alloxan resulted in a significant increase of glucose concentration in blood, whereas the concentration of glucose didn’t change at the injection of physiological solution. In control, the addition of NaHS resulted in a significant dose-dependent decrease of the amplitude of contraction of the myocardium, whereas the negative inotropic effect of NaHS was significantly lower in terms of modeling diabetes compare to control conditions. In the control, L-cysteine reduced the amplitude contractions significantly, whereas L-cysteine did not lead to significant changes in the amplitude of contractions in terms of modeling diabetes. These data indicate that the sensitivity of mice’s atria reduced for H2S and L-cysteine in diabetes mellitus. |
| format | Article |
| id | doaj-art-30f0bce93a3242e58a70325ded35dfd8 |
| institution | DOAJ |
| issn | 1682-0363 1819-3684 |
| language | English |
| publishDate | 2014-12-01 |
| publisher | Siberian State Medical University (Tomsk) |
| record_format | Article |
| series | Бюллетень сибирской медицины |
| spelling | doaj-art-30f0bce93a3242e58a70325ded35dfd82025-08-20T03:02:22ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842014-12-0113615515910.20538/1682-0363-2014-6-155-159163EFFECT OF HYDROGEN SULFIDE ON ATRIUM CONTRACTILITY IN CONTROL AND DIABETHIC MICEA. S. Lifanova0O. V. Yakovleva1A. I. Zefirov2G. F. Sitdikova3Kazan Federal University, KazanKazan Federal University, KazanKazan State Medical University, KazanKazan Federal University, KazanHydrogen sulfide (H2S) is endogenously synthesized gasotransmitter that has a regulatory effect in cardiovascular system. Diabetes mellitus leads to an increased risk of hypertension and cardiovascular diseases, so the purpose of the study was to analyze the contractility of the atria mice after application of L-cysteine and H2S. Contractile activity of the myocardium was investigated in the experiment on isolated mouse atria. Alloxan was used for modeling diabetes. Intraperitoneal injection of alloxan resulted in a significant increase of glucose concentration in blood, whereas the concentration of glucose didn’t change at the injection of physiological solution. In control, the addition of NaHS resulted in a significant dose-dependent decrease of the amplitude of contraction of the myocardium, whereas the negative inotropic effect of NaHS was significantly lower in terms of modeling diabetes compare to control conditions. In the control, L-cysteine reduced the amplitude contractions significantly, whereas L-cysteine did not lead to significant changes in the amplitude of contractions in terms of modeling diabetes. These data indicate that the sensitivity of mice’s atria reduced for H2S and L-cysteine in diabetes mellitus.https://bulletin.ssmu.ru/jour/article/view/165hydrogen sulfidemouse atriuml-cysteinediabetesalloxan |
| spellingShingle | A. S. Lifanova O. V. Yakovleva A. I. Zefirov G. F. Sitdikova EFFECT OF HYDROGEN SULFIDE ON ATRIUM CONTRACTILITY IN CONTROL AND DIABETHIC MICE Бюллетень сибирской медицины hydrogen sulfide mouse atrium l-cysteine diabetes alloxan |
| title | EFFECT OF HYDROGEN SULFIDE ON ATRIUM CONTRACTILITY IN CONTROL AND DIABETHIC MICE |
| title_full | EFFECT OF HYDROGEN SULFIDE ON ATRIUM CONTRACTILITY IN CONTROL AND DIABETHIC MICE |
| title_fullStr | EFFECT OF HYDROGEN SULFIDE ON ATRIUM CONTRACTILITY IN CONTROL AND DIABETHIC MICE |
| title_full_unstemmed | EFFECT OF HYDROGEN SULFIDE ON ATRIUM CONTRACTILITY IN CONTROL AND DIABETHIC MICE |
| title_short | EFFECT OF HYDROGEN SULFIDE ON ATRIUM CONTRACTILITY IN CONTROL AND DIABETHIC MICE |
| title_sort | effect of hydrogen sulfide on atrium contractility in control and diabethic mice |
| topic | hydrogen sulfide mouse atrium l-cysteine diabetes alloxan |
| url | https://bulletin.ssmu.ru/jour/article/view/165 |
| work_keys_str_mv | AT aslifanova effectofhydrogensulfideonatriumcontractilityincontrolanddiabethicmice AT ovyakovleva effectofhydrogensulfideonatriumcontractilityincontrolanddiabethicmice AT aizefirov effectofhydrogensulfideonatriumcontractilityincontrolanddiabethicmice AT gfsitdikova effectofhydrogensulfideonatriumcontractilityincontrolanddiabethicmice |