Comparison of the healing process of xenografts with three different sources in critical-size bone defects: An in vivo study
Background. Xenograft bone substitutes can be obtained from different animals and processed using various methods. The present in vivo study evaluated bone regeneration after using three types of xenografts with different sources in critical-sized bone defects in rabbit calvaria. Methods. Four 8-mm...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Tabriz University of Medical Sciences
2024-05-01
|
| Series: | Journal of Advanced Periodontology and Implant Dentistry |
| Subjects: | |
| Online Access: | https://japid.tbzmed.ac.ir/PDF/japid-16-22.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850263768712347648 |
|---|---|
| author | Reza Amid Mahdi Kadkhodazadeh Aida Kheiri Shiva Esfandiari |
| author_facet | Reza Amid Mahdi Kadkhodazadeh Aida Kheiri Shiva Esfandiari |
| author_sort | Reza Amid |
| collection | DOAJ |
| description | Background. Xenograft bone substitutes can be obtained from different animals and processed using various methods. The present in vivo study evaluated bone regeneration after using three types of xenografts with different sources in critical-sized bone defects in rabbit calvaria. Methods. Four 8-mm defects were created in calvaria of 14 New Zealand and white male rabbits. Three out of four defects were filled with xenografts of bovine, camel, and ostrich sources. The fourth defect was left unfilled as the control group. Seven rabbits were sacrificed after eight weeks and seven others after 12 weeks. Micro-CT imaging and histologic evaluation were further performed on dissected calvarias. Results. After 8 and 12 weeks, the highest and lowest percentages of new bone formation were observed in the camel (27.71% and 41.92%) and control (11.33% and 15.96%) groups, respectively. In the case of residual material, the ostrich group had the most value after eight weeks (53%), while after 12 weeks, it was highest in the camel group (37%). Micro-CT findings were consistent with histologic results. Conclusion. Although all three xenografts can be good choices for treating bone defects, camel-sourced xenograft seemed to be better than the other two groups. The origin and processing procedures of xenografts affected their final characteristics, which should be considered for clinical use. |
| format | Article |
| id | doaj-art-30f071b3195543e6a52d035cbafe82ee |
| institution | OA Journals |
| issn | 2645-5390 |
| language | English |
| publishDate | 2024-05-01 |
| publisher | Tabriz University of Medical Sciences |
| record_format | Article |
| series | Journal of Advanced Periodontology and Implant Dentistry |
| spelling | doaj-art-30f071b3195543e6a52d035cbafe82ee2025-08-20T01:54:54ZengTabriz University of Medical SciencesJournal of Advanced Periodontology and Implant Dentistry2645-53902024-05-01161222910.34172/japid.2024.004japid-3419Comparison of the healing process of xenografts with three different sources in critical-size bone defects: An in vivo studyReza Amid0Mahdi Kadkhodazadeh1Aida Kheiri2Shiva Esfandiari3Dental Research Center, Research Institute of Dental Sciences, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, IranDental Research Center, Research Institute of Dental Sciences, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, IranDental Research Center, Research Institute of Dental Sciences, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Biology, School of Science, Shahid Beheshti University, Tehran, IranBackground. Xenograft bone substitutes can be obtained from different animals and processed using various methods. The present in vivo study evaluated bone regeneration after using three types of xenografts with different sources in critical-sized bone defects in rabbit calvaria. Methods. Four 8-mm defects were created in calvaria of 14 New Zealand and white male rabbits. Three out of four defects were filled with xenografts of bovine, camel, and ostrich sources. The fourth defect was left unfilled as the control group. Seven rabbits were sacrificed after eight weeks and seven others after 12 weeks. Micro-CT imaging and histologic evaluation were further performed on dissected calvarias. Results. After 8 and 12 weeks, the highest and lowest percentages of new bone formation were observed in the camel (27.71% and 41.92%) and control (11.33% and 15.96%) groups, respectively. In the case of residual material, the ostrich group had the most value after eight weeks (53%), while after 12 weeks, it was highest in the camel group (37%). Micro-CT findings were consistent with histologic results. Conclusion. Although all three xenografts can be good choices for treating bone defects, camel-sourced xenograft seemed to be better than the other two groups. The origin and processing procedures of xenografts affected their final characteristics, which should be considered for clinical use.https://japid.tbzmed.ac.ir/PDF/japid-16-22.pdfbone graftingbone regenerationbone substitutesxenograft |
| spellingShingle | Reza Amid Mahdi Kadkhodazadeh Aida Kheiri Shiva Esfandiari Comparison of the healing process of xenografts with three different sources in critical-size bone defects: An in vivo study Journal of Advanced Periodontology and Implant Dentistry bone grafting bone regeneration bone substitutes xenograft |
| title | Comparison of the healing process of xenografts with three different sources in critical-size bone defects: An in vivo study |
| title_full | Comparison of the healing process of xenografts with three different sources in critical-size bone defects: An in vivo study |
| title_fullStr | Comparison of the healing process of xenografts with three different sources in critical-size bone defects: An in vivo study |
| title_full_unstemmed | Comparison of the healing process of xenografts with three different sources in critical-size bone defects: An in vivo study |
| title_short | Comparison of the healing process of xenografts with three different sources in critical-size bone defects: An in vivo study |
| title_sort | comparison of the healing process of xenografts with three different sources in critical size bone defects an in vivo study |
| topic | bone grafting bone regeneration bone substitutes xenograft |
| url | https://japid.tbzmed.ac.ir/PDF/japid-16-22.pdf |
| work_keys_str_mv | AT rezaamid comparisonofthehealingprocessofxenograftswiththreedifferentsourcesincriticalsizebonedefectsaninvivostudy AT mahdikadkhodazadeh comparisonofthehealingprocessofxenograftswiththreedifferentsourcesincriticalsizebonedefectsaninvivostudy AT aidakheiri comparisonofthehealingprocessofxenograftswiththreedifferentsourcesincriticalsizebonedefectsaninvivostudy AT shivaesfandiari comparisonofthehealingprocessofxenograftswiththreedifferentsourcesincriticalsizebonedefectsaninvivostudy |