Hypoxic conditions affect transcriptome of endometrial stromal cells in endometriosis and promote TGFBI axis

Hypoxic conditions affect transcriptome of endometrial stromal cells in endometriosis and promote TGFBI axis

BackgroundEndometriosis is characterized by the ectopic growth of endometrial-like cells, causing chronic pelvic pain, adhesions and impaired fertility in women of reproductive age. Usually, these lesions grow in the peritoneal cavity in a hypoxic environment. Hypoxia is known to affect gene express...

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Main Authors: Meruert Sarsenova, Nageswara Rao Boggavarapu, Keiu Kask, Vijayachitra Modhukur, Külli Samuel, Helle Karro, Kristina Gemzell-Danielsson, Parameswaran Grace Luther Lalitkumar, Andres Salumets, Maire Peters, Darja Lavogina
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Endocrinology
Subjects:
endometriosis
hypoxia
stromal cell cultures
transcriptomics
peritoneal lesions
TGFBI
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2024.1465393/full
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