A novel transendoscopically implantable miniature silicone-rubber marker emitting high-intensity near-infrared fluorescence for image-guided laparoscopic gastrointestinal surgery: HICARL bullet
Background: A recent advancement in imaging technology for near-infrared fluorescence (NIRF) with high penetrance of biological tissues allows for precise and safe image-guided surgery. Here, we developed a prototype of a transendoscopically implantable miniature NIRF silicone-rubber marker, HICARL...
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Elsevier
2025-08-01
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| Series: | Photodiagnosis and Photodynamic Therapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1572100025002273 |
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| author | Takayuki Sato Tetsuo Sumida Hiromi Sato |
| author_facet | Takayuki Sato Tetsuo Sumida Hiromi Sato |
| author_sort | Takayuki Sato |
| collection | DOAJ |
| description | Background: A recent advancement in imaging technology for near-infrared fluorescence (NIRF) with high penetrance of biological tissues allows for precise and safe image-guided surgery. Here, we developed a prototype of a transendoscopically implantable miniature NIRF silicone-rubber marker, HICARL bullet, and experimentally confirmed its NIRF performance required for image-guided laparoscopic surgery of the alimentary tract. Methods: The HICARL bullet with a diameter of 0.7 mm and a length of 3 mm was molded from NIRF silicone rubber we developed previously, emitting NIRF at a wavelength of 820–880 nm in response to excitation light at a wavelength of 740–800 nm. A specialized tool was fabricated for transendoscopically implanting the HICARL bullet into the submucosa of the alimentary tract through a forceps bore within a gastrointestinal videoscope. Results: The HICARL bullet demonstrated 9.3 times higher NIRF brightness than an ethanol solution of indocyanine green (5 μg/mL), and was unambiguously identified by its NIRF with high intensity through a 15-mm-thick chicken muscle strip. The transendoscopically implanted HICARL bullet into the submucosa of an in vivo porcine stomach exhibited superior visibility from the serosa side when compared to a commercially available NIRF clip (ZEOCLIP FS, Zeon Medical) placed on the mucosa. Conclusions: The HICARL bullet could serve as a promising NIRF marker for reliably delineating the demarcation line during image-guided laparoscopic surgery for gastrointestinal cancer. |
| format | Article |
| id | doaj-art-30ec10da3a604e629b8395cb8769d38d |
| institution | Kabale University |
| issn | 1572-1000 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Photodiagnosis and Photodynamic Therapy |
| spelling | doaj-art-30ec10da3a604e629b8395cb8769d38d2025-08-20T04:00:40ZengElsevierPhotodiagnosis and Photodynamic Therapy1572-10002025-08-015410469510.1016/j.pdpdt.2025.104695A novel transendoscopically implantable miniature silicone-rubber marker emitting high-intensity near-infrared fluorescence for image-guided laparoscopic gastrointestinal surgery: HICARL bulletTakayuki Sato0Tetsuo Sumida1Hiromi Sato2Department of Cardiovascular Control, Kochi Medical School, Nankoku 783-8505, Japan; Corresponding author.Nirec Corporation, Kochi 781-0083, JapanNirec Corporation, Kochi 781-0083, JapanBackground: A recent advancement in imaging technology for near-infrared fluorescence (NIRF) with high penetrance of biological tissues allows for precise and safe image-guided surgery. Here, we developed a prototype of a transendoscopically implantable miniature NIRF silicone-rubber marker, HICARL bullet, and experimentally confirmed its NIRF performance required for image-guided laparoscopic surgery of the alimentary tract. Methods: The HICARL bullet with a diameter of 0.7 mm and a length of 3 mm was molded from NIRF silicone rubber we developed previously, emitting NIRF at a wavelength of 820–880 nm in response to excitation light at a wavelength of 740–800 nm. A specialized tool was fabricated for transendoscopically implanting the HICARL bullet into the submucosa of the alimentary tract through a forceps bore within a gastrointestinal videoscope. Results: The HICARL bullet demonstrated 9.3 times higher NIRF brightness than an ethanol solution of indocyanine green (5 μg/mL), and was unambiguously identified by its NIRF with high intensity through a 15-mm-thick chicken muscle strip. The transendoscopically implanted HICARL bullet into the submucosa of an in vivo porcine stomach exhibited superior visibility from the serosa side when compared to a commercially available NIRF clip (ZEOCLIP FS, Zeon Medical) placed on the mucosa. Conclusions: The HICARL bullet could serve as a promising NIRF marker for reliably delineating the demarcation line during image-guided laparoscopic surgery for gastrointestinal cancer.http://www.sciencedirect.com/science/article/pii/S1572100025002273Image-guided surgeryLaparoscopic surgeryNear-infrared fluorescenceSilicone rubberTransendoscopic implant |
| spellingShingle | Takayuki Sato Tetsuo Sumida Hiromi Sato A novel transendoscopically implantable miniature silicone-rubber marker emitting high-intensity near-infrared fluorescence for image-guided laparoscopic gastrointestinal surgery: HICARL bullet Photodiagnosis and Photodynamic Therapy Image-guided surgery Laparoscopic surgery Near-infrared fluorescence Silicone rubber Transendoscopic implant |
| title | A novel transendoscopically implantable miniature silicone-rubber marker emitting high-intensity near-infrared fluorescence for image-guided laparoscopic gastrointestinal surgery: HICARL bullet |
| title_full | A novel transendoscopically implantable miniature silicone-rubber marker emitting high-intensity near-infrared fluorescence for image-guided laparoscopic gastrointestinal surgery: HICARL bullet |
| title_fullStr | A novel transendoscopically implantable miniature silicone-rubber marker emitting high-intensity near-infrared fluorescence for image-guided laparoscopic gastrointestinal surgery: HICARL bullet |
| title_full_unstemmed | A novel transendoscopically implantable miniature silicone-rubber marker emitting high-intensity near-infrared fluorescence for image-guided laparoscopic gastrointestinal surgery: HICARL bullet |
| title_short | A novel transendoscopically implantable miniature silicone-rubber marker emitting high-intensity near-infrared fluorescence for image-guided laparoscopic gastrointestinal surgery: HICARL bullet |
| title_sort | novel transendoscopically implantable miniature silicone rubber marker emitting high intensity near infrared fluorescence for image guided laparoscopic gastrointestinal surgery hicarl bullet |
| topic | Image-guided surgery Laparoscopic surgery Near-infrared fluorescence Silicone rubber Transendoscopic implant |
| url | http://www.sciencedirect.com/science/article/pii/S1572100025002273 |
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