Early plasma ferritin concentrations are not associated with time to red cell transfusions in extremely and very preterm neonates: a prospective single-site observational study
Objective To assess the relationship between plasma ferritin concentrations and (1) antenatal factors and (2) requirement for red cell transfusion.Study design This single-site prospective study recruited infants in the first week of life who were born <32 weeks’ corrected gestational age and...
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BMJ Publishing Group
2025-02-01
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| Series: | BMJ Paediatrics Open |
| Online Access: | https://bmjpaedsopen.bmj.com/content/9/1/e002967.full |
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| author | Naomi McCallion Áine Fox Fionnuala Ní Áinle Claire Murphy Lauren Murphy Daniel O'Reilly Anna-Claire Glynn Grainne Kelleher |
| author_facet | Naomi McCallion Áine Fox Fionnuala Ní Áinle Claire Murphy Lauren Murphy Daniel O'Reilly Anna-Claire Glynn Grainne Kelleher |
| author_sort | Naomi McCallion |
| collection | DOAJ |
| description | Objective To assess the relationship between plasma ferritin concentrations and (1) antenatal factors and (2) requirement for red cell transfusion.Study design This single-site prospective study recruited infants in the first week of life who were born <32 weeks’ corrected gestational age and did not receive a red cell transfusion prior to sampling. Ferritin concentrations were assessed on discard plasma taken as part of routine neonatal investigations in the first week of life (median day of life=3, IQR 2–5 days). Reasons for delivery, placental histology and demographics were recorded.Results Plasma ferritin concentrations were not significantly associated with birth weight or gestational age in this cohort of extremely/very preterm neonates (n=114: n=26, <28 weeks’ corrected gestational age; n=88, 28–32 weeks’ corrected gestational age). Neonates exposed to chorioamnionitis had an increased ferritin concentration versus those who were not. Neonates exposed to pre-eclampsia had a significantly lower ferritin concentration than those who were not. Early ferritin concentration was not associated with time to transfusion in a time to event analysis.Conclusions Plasma ferritin concentrations in very/extremely preterm neonates are variable and associated with the intrauterine environment. Ferritin concentration was not predictive of time to transfusion in this cohort and was not significantly different at smaller birth weight or earlier gestation. This is important for considerations of iron storage in very preterm neonates and its developmental consequences. |
| format | Article |
| id | doaj-art-30e77141953e459d87486953e8c1d40b |
| institution | Kabale University |
| issn | 2399-9772 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Paediatrics Open |
| spelling | doaj-art-30e77141953e459d87486953e8c1d40b2025-02-06T12:25:08ZengBMJ Publishing GroupBMJ Paediatrics Open2399-97722025-02-019110.1136/bmjpo-2024-002967Early plasma ferritin concentrations are not associated with time to red cell transfusions in extremely and very preterm neonates: a prospective single-site observational studyNaomi McCallion0Áine Fox1Fionnuala Ní Áinle2Claire Murphy3Lauren Murphy4Daniel O'Reilly5Anna-Claire Glynn6Grainne Kelleher74Department of Paediatrics, RCSI, Dublin, IrelandNeonatology, Rotunda Hospital Neonatal Unit, Dublin, IrelandHaematology, Rotunda Hospital, Dublin, IrelandInstitute of Clinical Trials and Methodology - MRC CTU at UCL, University College London, London, UK1Department of Reproductive and Developmental Sciences, Edinburgh, UKDepartment of Paediatrics, Midland Regional Hospital, Mullingar, IrelandNutrition and Dietetics, Rotunda Hospital, Dublin, IrelandDepartment of Biochemistry, Rotunda Hospital, Dublin, IrelandObjective To assess the relationship between plasma ferritin concentrations and (1) antenatal factors and (2) requirement for red cell transfusion.Study design This single-site prospective study recruited infants in the first week of life who were born <32 weeks’ corrected gestational age and did not receive a red cell transfusion prior to sampling. Ferritin concentrations were assessed on discard plasma taken as part of routine neonatal investigations in the first week of life (median day of life=3, IQR 2–5 days). Reasons for delivery, placental histology and demographics were recorded.Results Plasma ferritin concentrations were not significantly associated with birth weight or gestational age in this cohort of extremely/very preterm neonates (n=114: n=26, <28 weeks’ corrected gestational age; n=88, 28–32 weeks’ corrected gestational age). Neonates exposed to chorioamnionitis had an increased ferritin concentration versus those who were not. Neonates exposed to pre-eclampsia had a significantly lower ferritin concentration than those who were not. Early ferritin concentration was not associated with time to transfusion in a time to event analysis.Conclusions Plasma ferritin concentrations in very/extremely preterm neonates are variable and associated with the intrauterine environment. Ferritin concentration was not predictive of time to transfusion in this cohort and was not significantly different at smaller birth weight or earlier gestation. This is important for considerations of iron storage in very preterm neonates and its developmental consequences.https://bmjpaedsopen.bmj.com/content/9/1/e002967.full |
| spellingShingle | Naomi McCallion Áine Fox Fionnuala Ní Áinle Claire Murphy Lauren Murphy Daniel O'Reilly Anna-Claire Glynn Grainne Kelleher Early plasma ferritin concentrations are not associated with time to red cell transfusions in extremely and very preterm neonates: a prospective single-site observational study BMJ Paediatrics Open |
| title | Early plasma ferritin concentrations are not associated with time to red cell transfusions in extremely and very preterm neonates: a prospective single-site observational study |
| title_full | Early plasma ferritin concentrations are not associated with time to red cell transfusions in extremely and very preterm neonates: a prospective single-site observational study |
| title_fullStr | Early plasma ferritin concentrations are not associated with time to red cell transfusions in extremely and very preterm neonates: a prospective single-site observational study |
| title_full_unstemmed | Early plasma ferritin concentrations are not associated with time to red cell transfusions in extremely and very preterm neonates: a prospective single-site observational study |
| title_short | Early plasma ferritin concentrations are not associated with time to red cell transfusions in extremely and very preterm neonates: a prospective single-site observational study |
| title_sort | early plasma ferritin concentrations are not associated with time to red cell transfusions in extremely and very preterm neonates a prospective single site observational study |
| url | https://bmjpaedsopen.bmj.com/content/9/1/e002967.full |
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