Backtranslation of human RNA biosignatures of tuberculosis disease risk into the preclinical pipeline is condition dependent

Backtranslation of human RNA biosignatures of tuberculosis disease risk into the preclinical pipeline is condition dependent

ABSTRACT It is unclear whether human progression to active tuberculosis disease (TB) risk signatures are viable endpoint criteria for evaluations of treatments in development. TB is the deadliest infectious disease globally and more efficacious vaccines are needed to reduce this mortality. However,...

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Bibliographic Details
Main Authors: Hannah Painter, Sasha E. Larsen, Brittany D. Williams, Hazem F. M. Abdelaal, Susan L. Baldwin, Helen A. Fletcher, Andrew Fiore-Gartland, Rhea N. Coler
Format: Article
Language:English
Published: American Society for Microbiology 2025-01-01
Series:mSphere
Subjects:
tuberculosis
tuberculosis vaccines
RNA risk signature
correlate of risk
preclinical drug studies
Online Access:https://journals.asm.org/doi/10.1128/msphere.00864-24
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