Inhibition of the LINE1-derived MET transcript induces apoptosis and oncoprotein knockdown in cancer cells

Inhibition of the LINE1-derived MET transcript induces apoptosis and oncoprotein knockdown in cancer cells

The expression of intragenic long interspersed nuclear elements 1 (LINE1s) can generate chimeric sequences disrupting host gene transcription. Among these, L1-MET, within mesenchymal epithelial transition (MET) oncogene, is particularly interesting, as its expression has been associated with the acq...

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Bibliographic Details
Main Authors: Umberto Miglio, Enrico Berrino, Daniele Avanzato, Ivan Molineris, Valentina Miano, Melissa Milan, Letizia Lanzetti, Eugenio Morelli, James M. Hughes, Michele De Bortoli, Anna Sapino, Tiziana Venesio
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
MT: Oligonucleotides: Therapies and Applications
L1-MET
chimeric transcript
cancer cell death
MET protein knockdown
intragenic-LINE1-derived transcript targeting
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253125000836
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