3D-printed copper-containing tailored titanium alloys with corrosion resistance, biocompatibility, and anti-inflammatory properties for enhanced guided bone regeneration
IntroductionGuided bone regeneration (GBR) serves as a critical technique in dental implantology, relying heavily on barrier membranes for successful alveolar bone augmentation. Titanium mesh, widely utilized in GBR procedures, faces a high exposure rate that leads to infections and compromised clin...
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Frontiers Media S.A.
2025-08-01
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| author | Lan Luo Lan Luo Quan Zhong Quan Zhong Zi-Qin Chen Zi-Qin Chen Xiao-Hong Wu Xiao-Hong Wu Shu-Man Li Zhen-Zhu Xue Zhen-Zhu Xue Yan-Jin Lu Kai Luo Kai Luo Wei Zhao Wei Zhao |
| author_facet | Lan Luo Lan Luo Quan Zhong Quan Zhong Zi-Qin Chen Zi-Qin Chen Xiao-Hong Wu Xiao-Hong Wu Shu-Man Li Zhen-Zhu Xue Zhen-Zhu Xue Yan-Jin Lu Kai Luo Kai Luo Wei Zhao Wei Zhao |
| author_sort | Lan Luo |
| collection | DOAJ |
| description | IntroductionGuided bone regeneration (GBR) serves as a critical technique in dental implantology, relying heavily on barrier membranes for successful alveolar bone augmentation. Titanium mesh, widely utilized in GBR procedures, faces a high exposure rate that leads to infections and compromised clinical outcomes. While 3D-printed personalized meshes have reduced exposure rates, infection risks persist, necessitating the development of bioactive solutions.MethodsIn this study, selective laser melting (SLM) was employed to fabricate copper-bearing titanium meshes using Ti-xCu powders (x=0, 4, 6, 8 wt%). This investigation systematically evaluated the effects of copper content on corrosion resistance, biocompatibility, osteogenic potential, and anti-inflammatory properties of the Ti-xCu alloys.ResultsMicrostructural analysis revealed that increasing copper content enhanced Ti2Cu precipitation within the α-Ti matrix. While increased copper content did not compromise corrosion resistance, it resulted in higher copper ion release concentrations. Antibacterial assays demonstrated that alloys with copper content exceeding 4 wt% exhibited >90% bacterial reduction against S. aureus and E. coli. In vitro studies showed that Ti-6Cu optimally promoted osteoblast proliferation and upregulated osteogenic genes (Alp, Col-1). Furthermore, Ti-6Cu upregulated anti-inflammatory factors (Il-10, Arg-1) while downregulating inflammatory factors (Tnf-α, Il-6).ConclusionThe study established SLM-treated antibacterial Ti-6Cu alloy exhibited favorable biological activity, demonstrating promising potential for application in regeneration scaffolds. |
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| institution | Kabale University |
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| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj-art-30dbe249c2034aa0a3eae445bef27f322025-08-21T05:27:25ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852025-08-011310.3389/fbioe.2025.164767816476783D-printed copper-containing tailored titanium alloys with corrosion resistance, biocompatibility, and anti-inflammatory properties for enhanced guided bone regenerationLan Luo0Lan Luo1Quan Zhong2Quan Zhong3Zi-Qin Chen4Zi-Qin Chen5Xiao-Hong Wu6Xiao-Hong Wu7Shu-Man Li8Zhen-Zhu Xue9Zhen-Zhu Xue10Yan-Jin Lu11Kai Luo12Kai Luo13Wei Zhao14Wei Zhao15Institute of Stomatology and Laboratory of Oral Tissue Engineering, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, ChinaFujian Key Laboratory of Oral Diseases and Fujian Provincial Engineering Research Center of Oral Biomaterial and Stomatological Key laboratory of Fujian College and University, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, ChinaInstitute of Stomatology and Laboratory of Oral Tissue Engineering, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, ChinaFujian Key Laboratory of Oral Diseases and Fujian Provincial Engineering Research Center of Oral Biomaterial and Stomatological Key laboratory of Fujian College and University, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, ChinaInstitute of Stomatology and Laboratory of Oral Tissue Engineering, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, ChinaFujian Key Laboratory of Oral Diseases and Fujian Provincial Engineering Research Center of Oral Biomaterial and Stomatological Key laboratory of Fujian College and University, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, ChinaInstitute of Stomatology and Laboratory of Oral Tissue Engineering, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, ChinaFujian Key Laboratory of Oral Diseases and Fujian Provincial Engineering Research Center of Oral Biomaterial and Stomatological Key laboratory of Fujian College and University, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, ChinaDepartment of Stomatology, Fujian Provincial Geriatric Hospital, Fuzhou, ChinaInstitute of Stomatology and Laboratory of Oral Tissue Engineering, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, ChinaFujian Key Laboratory of Oral Diseases and Fujian Provincial Engineering Research Center of Oral Biomaterial and Stomatological Key laboratory of Fujian College and University, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, ChinaKey Laboratory of Opto-Electronic Science and Technology for Medicine of Ministry of Education, College of Photonic and Electronic Engineering, Fujian Normal University, Fuzhou, ChinaInstitute of Stomatology and Laboratory of Oral Tissue Engineering, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, ChinaFujian Key Laboratory of Oral Diseases and Fujian Provincial Engineering Research Center of Oral Biomaterial and Stomatological Key laboratory of Fujian College and University, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, ChinaInstitute of Stomatology and Laboratory of Oral Tissue Engineering, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, ChinaFujian Key Laboratory of Oral Diseases and Fujian Provincial Engineering Research Center of Oral Biomaterial and Stomatological Key laboratory of Fujian College and University, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, ChinaIntroductionGuided bone regeneration (GBR) serves as a critical technique in dental implantology, relying heavily on barrier membranes for successful alveolar bone augmentation. Titanium mesh, widely utilized in GBR procedures, faces a high exposure rate that leads to infections and compromised clinical outcomes. While 3D-printed personalized meshes have reduced exposure rates, infection risks persist, necessitating the development of bioactive solutions.MethodsIn this study, selective laser melting (SLM) was employed to fabricate copper-bearing titanium meshes using Ti-xCu powders (x=0, 4, 6, 8 wt%). This investigation systematically evaluated the effects of copper content on corrosion resistance, biocompatibility, osteogenic potential, and anti-inflammatory properties of the Ti-xCu alloys.ResultsMicrostructural analysis revealed that increasing copper content enhanced Ti2Cu precipitation within the α-Ti matrix. While increased copper content did not compromise corrosion resistance, it resulted in higher copper ion release concentrations. Antibacterial assays demonstrated that alloys with copper content exceeding 4 wt% exhibited >90% bacterial reduction against S. aureus and E. coli. In vitro studies showed that Ti-6Cu optimally promoted osteoblast proliferation and upregulated osteogenic genes (Alp, Col-1). Furthermore, Ti-6Cu upregulated anti-inflammatory factors (Il-10, Arg-1) while downregulating inflammatory factors (Tnf-α, Il-6).ConclusionThe study established SLM-treated antibacterial Ti-6Cu alloy exhibited favorable biological activity, demonstrating promising potential for application in regeneration scaffolds.https://www.frontiersin.org/articles/10.3389/fbioe.2025.1647678/fullTi-Cu alloycorrosion resistancebiocompatibilityanti-inflammatoryosteogenesis |
| spellingShingle | Lan Luo Lan Luo Quan Zhong Quan Zhong Zi-Qin Chen Zi-Qin Chen Xiao-Hong Wu Xiao-Hong Wu Shu-Man Li Zhen-Zhu Xue Zhen-Zhu Xue Yan-Jin Lu Kai Luo Kai Luo Wei Zhao Wei Zhao 3D-printed copper-containing tailored titanium alloys with corrosion resistance, biocompatibility, and anti-inflammatory properties for enhanced guided bone regeneration Frontiers in Bioengineering and Biotechnology Ti-Cu alloy corrosion resistance biocompatibility anti-inflammatory osteogenesis |
| title | 3D-printed copper-containing tailored titanium alloys with corrosion resistance, biocompatibility, and anti-inflammatory properties for enhanced guided bone regeneration |
| title_full | 3D-printed copper-containing tailored titanium alloys with corrosion resistance, biocompatibility, and anti-inflammatory properties for enhanced guided bone regeneration |
| title_fullStr | 3D-printed copper-containing tailored titanium alloys with corrosion resistance, biocompatibility, and anti-inflammatory properties for enhanced guided bone regeneration |
| title_full_unstemmed | 3D-printed copper-containing tailored titanium alloys with corrosion resistance, biocompatibility, and anti-inflammatory properties for enhanced guided bone regeneration |
| title_short | 3D-printed copper-containing tailored titanium alloys with corrosion resistance, biocompatibility, and anti-inflammatory properties for enhanced guided bone regeneration |
| title_sort | 3d printed copper containing tailored titanium alloys with corrosion resistance biocompatibility and anti inflammatory properties for enhanced guided bone regeneration |
| topic | Ti-Cu alloy corrosion resistance biocompatibility anti-inflammatory osteogenesis |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2025.1647678/full |
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