Pharmacokinetic comparisons of S-oxiracetam and R-oxiracetam in beagle dogs
A pharmacokinetic comparison and conformational stability study of S-oxiracetam (S-ORT) and R-oxiracetam (R-ORT) in beagle dogs was used to investigate the possible mechanism of different effects of two oxiracetam enantiomers through a random crossover design. After drug administration to beagle dog...
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| Format: | Article |
| Language: | English |
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Sciendo
2016-06-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.1515/acph-2016-0013 |
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| author | Wang Wusan Ji Hui Li Tingting Jia Yuanwei Xie Haitang |
| author_facet | Wang Wusan Ji Hui Li Tingting Jia Yuanwei Xie Haitang |
| author_sort | Wang Wusan |
| collection | DOAJ |
| description | A pharmacokinetic comparison and conformational stability study of S-oxiracetam (S-ORT) and R-oxiracetam (R-ORT) in beagle dogs was used to investigate the possible mechanism of different effects of two oxiracetam enantiomers through a random crossover design. After drug administration to beagle dogs, blood samples were collected at different time points for pharmacokinetic analysis using the UPLC-ESI-MS/MS method. Parts of plasma samples were used for conformation transformation studies using a normal phase high performance liquid chromatographic (NP HPLC) method. The study showed that oxiracetam enantiomers maintained their original conformation when administered orally to beagle dogs. Concentrations of S-ORT were significantly higher than R-ORT 1.5 and 2 h after administration; the AUC0-∞ of S-ORT after oral administration tended to be higher than that of R-ORT, which showed that the different effects between S-ORT and R-ORT may be partly associated with their distinctive absorption at least. |
| format | Article |
| id | doaj-art-30dbdb0dfa75485a85fa99d1284d0f03 |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2016-06-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-30dbdb0dfa75485a85fa99d1284d0f032025-02-02T09:55:40ZengSciendoActa Pharmaceutica1846-95582016-06-0166227928710.1515/acph-2016-0013acph-2016-0013Pharmacokinetic comparisons of S-oxiracetam and R-oxiracetam in beagle dogsWang Wusan0Ji Hui1Li Tingting2Jia Yuanwei3Xie Haitang4 Department of Pharmacology, College of Pharmacy, China Pharmaceutical University, Nanjing 210000, China Department of Pharmacology, College of Pharmacy, China Pharmaceutical University, Nanjing 210000, China Department of Pharmacology, College of Pharmacy, China Pharmaceutical University, Nanjing 210000, China Yijishan Hospital, Wannan Medical College, Wuhu 241002, Anhui Province, China Yijishan Hospital, Wannan Medical College, Wuhu 241002, Anhui Province, ChinaA pharmacokinetic comparison and conformational stability study of S-oxiracetam (S-ORT) and R-oxiracetam (R-ORT) in beagle dogs was used to investigate the possible mechanism of different effects of two oxiracetam enantiomers through a random crossover design. After drug administration to beagle dogs, blood samples were collected at different time points for pharmacokinetic analysis using the UPLC-ESI-MS/MS method. Parts of plasma samples were used for conformation transformation studies using a normal phase high performance liquid chromatographic (NP HPLC) method. The study showed that oxiracetam enantiomers maintained their original conformation when administered orally to beagle dogs. Concentrations of S-ORT were significantly higher than R-ORT 1.5 and 2 h after administration; the AUC0-∞ of S-ORT after oral administration tended to be higher than that of R-ORT, which showed that the different effects between S-ORT and R-ORT may be partly associated with their distinctive absorption at least.https://doi.org/10.1515/acph-2016-0013s-oxiracetamr-oxiracetamconformationpharmacokineticsbeagle dogs |
| spellingShingle | Wang Wusan Ji Hui Li Tingting Jia Yuanwei Xie Haitang Pharmacokinetic comparisons of S-oxiracetam and R-oxiracetam in beagle dogs Acta Pharmaceutica s-oxiracetam r-oxiracetam conformation pharmacokinetics beagle dogs |
| title | Pharmacokinetic comparisons of S-oxiracetam and R-oxiracetam in beagle dogs |
| title_full | Pharmacokinetic comparisons of S-oxiracetam and R-oxiracetam in beagle dogs |
| title_fullStr | Pharmacokinetic comparisons of S-oxiracetam and R-oxiracetam in beagle dogs |
| title_full_unstemmed | Pharmacokinetic comparisons of S-oxiracetam and R-oxiracetam in beagle dogs |
| title_short | Pharmacokinetic comparisons of S-oxiracetam and R-oxiracetam in beagle dogs |
| title_sort | pharmacokinetic comparisons of s oxiracetam and r oxiracetam in beagle dogs |
| topic | s-oxiracetam r-oxiracetam conformation pharmacokinetics beagle dogs |
| url | https://doi.org/10.1515/acph-2016-0013 |
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