Hematological phenotypes in GATA2 deficiency syndrome arise from aging, maladaptation to proliferation, and somatic events

Hematological phenotypes in GATA2 deficiency syndrome arise from aging, maladaptation to proliferation, and somatic events

Abstract: The GATA2 transcription factor is a pivotal regulator of hematopoiesis. Disruptions in the GATA2 gene drive severe hematologic abnormalities and are associated with an increased risk of myelodysplastic syndromes and acute myeloid leukemia; however, the mechanisms underlying the pathophysio...

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Main Authors: Juncal Fernandez-Orth, Cansu Koyunlar, Julia M. Weiss, Emanuele Gioacchino, Hans de Looper, Geoffroy Andrieux, Mariëtte ter Borg, Joke Zink, Irene Gonzalez-Menendez, Remco Hoogenboezem, Baris Yigit, Kirsten J. Gussinklo, Roger Mulet-Lazaro, Charlotte Wantzen, Sophie Pfeiffer, Christian Molnar, Eric Bindels, Sheila Bohler, Mathijs Sanders, Leticia Quintanilla-Martinez, Marcin Wlodarski, Melanie Boerries, Ivo P. Touw, Charlotte Niemeyer, Miriam Erlacher, Emma de Pater
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Blood Advances
Online Access:http://www.sciencedirect.com/science/article/pii/S2473952925001892
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