Species- and strain-specific microbial modulation of interferon, innate immunity, and epithelial barrier in 2D air–liquid interface respiratory epithelial cultures

Species- and strain-specific microbial modulation of interferon, innate immunity, and epithelial barrier in 2D air–liquid interface respiratory epithelial cultures

Abstract Background The microbiome regulates the respiratory epithelium’s immunomodulatory functions. To explore how the microbiome’s biodiversity affects microbe-epithelial interactions, we screened 58 phylogenetically diverse microbes for their transcriptomic effect on human primary bronchial air–...

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Main Authors: Mian Horvath, Ruoyu Yang, Diana Cadena Castaneda, Megan Callender, Elizabeth S. Aiken, Anita Y. Voigt, Ryan Caldwell, José Fachi, Blanda Di Luccia, Zoe Scholar, Peter Yu, Andrew Salner, Marco Colonna, Karolina Palucka, Julia Oh
Format: Article
Language:English
Published: BMC 2025-01-01
Series:BMC Biology
Subjects:
Respiratory microbiome
Bacteria
Epithelium
Interferon
Antiviral immunity
RNA-seq
Online Access:https://doi.org/10.1186/s12915-025-02129-7
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