In Situ Preservation Fraction of Parathyroid Gland in Thyroidectomy: A Cohort Retrospective Study
Background and Objectives. Parathyroid failure is the most common symptom after thyroidectomy. To prevent it, a gland was preserved in situ or an ischemic one was autotransplanted. This study explored the relationship between in situ preservation of the parathyroid gland and gland failure. Methods....
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| Format: | Article |
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Wiley
2018-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2018/7493143 |
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| author | Han Luo Wanjun Zhao Hongliu Yang Anping Su Bin Wang Jingqiang Zhu |
| author_facet | Han Luo Wanjun Zhao Hongliu Yang Anping Su Bin Wang Jingqiang Zhu |
| author_sort | Han Luo |
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| description | Background and Objectives. Parathyroid failure is the most common symptom after thyroidectomy. To prevent it, a gland was preserved in situ or an ischemic one was autotransplanted. This study explored the relationship between in situ preservation of the parathyroid gland and gland failure. Methods. Consecutive patients who underwent initial total thyroidectomy were enrolled retrospectively in a prospectively maintained database. Patients were divided into groups by parathyroid gland remaining in situ fraction (PGRIF) (PGRIF = number of in situ glands/(total number of identified glands − number of glands in specimen). Patients were graded by tertiles and followed at least one year after surgery. Results. 559 patients were included. PGRIF is significantly inversely associated with transient hypoparathyroidism, protracted hypoparathyroidism, and postoperative hypocalcemia. PGRIF was identified as an independent risk factor for transient hypoparathyroidism, protracted hypoparathyroidism, and postoperative hypocalcemia (OR=0.177, 0.190, and 0.330, resp.). Autotransplantation of parathyroid gland would not affect the calcium level in the long term. Conclusion. In situ preservation of parathyroid gland is crucial for parathyroid function. Less preserved is the independent risk factor for postoperative hypoparathyroidism and hypocalcemia, resulting in a worse function of parathyroid gland in the long term. |
| format | Article |
| id | doaj-art-30bff76dcd634e53b3cb64264fac3c1f |
| institution | OA Journals |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
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| series | International Journal of Endocrinology |
| spelling | doaj-art-30bff76dcd634e53b3cb64264fac3c1f2025-08-20T02:38:56ZengWileyInternational Journal of Endocrinology1687-83371687-83452018-01-01201810.1155/2018/74931437493143In Situ Preservation Fraction of Parathyroid Gland in Thyroidectomy: A Cohort Retrospective StudyHan Luo0Wanjun Zhao1Hongliu Yang2Anping Su3Bin Wang4Jingqiang Zhu5Thyroid & Breast Surgery, West China Hospital, Sichuan University, Chengdu, ChinaThyroid & Breast Surgery, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Nephrology, West China Hospital, Sichuan University, Chengdu, ChinaThyroid & Breast Surgery, West China Hospital, Sichuan University, Chengdu, ChinaThyroid & Breast Surgery, West China Hospital, Sichuan University, Chengdu, ChinaThyroid & Breast Surgery, West China Hospital, Sichuan University, Chengdu, ChinaBackground and Objectives. Parathyroid failure is the most common symptom after thyroidectomy. To prevent it, a gland was preserved in situ or an ischemic one was autotransplanted. This study explored the relationship between in situ preservation of the parathyroid gland and gland failure. Methods. Consecutive patients who underwent initial total thyroidectomy were enrolled retrospectively in a prospectively maintained database. Patients were divided into groups by parathyroid gland remaining in situ fraction (PGRIF) (PGRIF = number of in situ glands/(total number of identified glands − number of glands in specimen). Patients were graded by tertiles and followed at least one year after surgery. Results. 559 patients were included. PGRIF is significantly inversely associated with transient hypoparathyroidism, protracted hypoparathyroidism, and postoperative hypocalcemia. PGRIF was identified as an independent risk factor for transient hypoparathyroidism, protracted hypoparathyroidism, and postoperative hypocalcemia (OR=0.177, 0.190, and 0.330, resp.). Autotransplantation of parathyroid gland would not affect the calcium level in the long term. Conclusion. In situ preservation of parathyroid gland is crucial for parathyroid function. Less preserved is the independent risk factor for postoperative hypoparathyroidism and hypocalcemia, resulting in a worse function of parathyroid gland in the long term.http://dx.doi.org/10.1155/2018/7493143 |
| spellingShingle | Han Luo Wanjun Zhao Hongliu Yang Anping Su Bin Wang Jingqiang Zhu In Situ Preservation Fraction of Parathyroid Gland in Thyroidectomy: A Cohort Retrospective Study International Journal of Endocrinology |
| title | In Situ Preservation Fraction of Parathyroid Gland in Thyroidectomy: A Cohort Retrospective Study |
| title_full | In Situ Preservation Fraction of Parathyroid Gland in Thyroidectomy: A Cohort Retrospective Study |
| title_fullStr | In Situ Preservation Fraction of Parathyroid Gland in Thyroidectomy: A Cohort Retrospective Study |
| title_full_unstemmed | In Situ Preservation Fraction of Parathyroid Gland in Thyroidectomy: A Cohort Retrospective Study |
| title_short | In Situ Preservation Fraction of Parathyroid Gland in Thyroidectomy: A Cohort Retrospective Study |
| title_sort | in situ preservation fraction of parathyroid gland in thyroidectomy a cohort retrospective study |
| url | http://dx.doi.org/10.1155/2018/7493143 |
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