Clinicopathological Characteristics of Inflammatory Myofibroblastic Tumor: A Single Center Retrospective Cohort Study
ABSTRACT Background Inflammatory myofibroblastic tumor (IMT) is a rare intermediate‐grade neoplasm. It presents a great challenge in diagnosis and treatment. This study aims to identify the clinicopathological characteristics of IMT. Methods A retrospective study was conducted, enrolling patients wi...
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | Thoracic Cancer |
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| Online Access: | https://doi.org/10.1111/1759-7714.15496 |
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| author | Xiaoyan Si Shafei Wu Ruie Feng Mengzhao Wang Hanping Wang Xiaotong Zhang Li Zhang Kaifeng Xu |
| author_facet | Xiaoyan Si Shafei Wu Ruie Feng Mengzhao Wang Hanping Wang Xiaotong Zhang Li Zhang Kaifeng Xu |
| author_sort | Xiaoyan Si |
| collection | DOAJ |
| description | ABSTRACT Background Inflammatory myofibroblastic tumor (IMT) is a rare intermediate‐grade neoplasm. It presents a great challenge in diagnosis and treatment. This study aims to identify the clinicopathological characteristics of IMT. Methods A retrospective study was conducted, enrolling patients with IMT at Peking Union Medical College Hospital from January 2013 to October 2023. Clinical information, treatments, and efficacy were analyzed. Results A total of 72 patients were enrolled, including 38 men and 34 women, with a median age of 46.5 years. The most common primary site included the lung (n = 15, 20.8%), intestinal tract (n = 8, 11.1%), abdominal cavity (n = 7, 9.7%), and nasal sinus (n = 5, 6.9%). Thirty patients harbored anaplastic lymphoma kinase (ALK) fusion genes; Sixty‐five (90.3%) patients underwent surgical resection, and 11 of them had postoperative recurrence. Thirty patients received systemic therapy, including nonsteroidal anti‐inflammatory drugs (n = 1), steroids (n = 5), chemotherapy (n = 7), targeted therapy (n = 2), and immune checkpoint inhibitor (n = 1). Conclusions The most common site of IMT is the lung. Surgery is the main treatment for IMT, and postoperative adjuvant therapy for ALK‐positive patients needs to be focused. The molecular testing is essential for all patients diagnosed with IMTs. Systemic treatment needs further research. |
| format | Article |
| id | doaj-art-30b68a21d44543248f44c30bdda08daf |
| institution | DOAJ |
| issn | 1759-7706 1759-7714 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Thoracic Cancer |
| spelling | doaj-art-30b68a21d44543248f44c30bdda08daf2025-08-20T02:59:14ZengWileyThoracic Cancer1759-77061759-77142025-01-01161n/an/a10.1111/1759-7714.15496Clinicopathological Characteristics of Inflammatory Myofibroblastic Tumor: A Single Center Retrospective Cohort StudyXiaoyan Si0Shafei Wu1Ruie Feng2Mengzhao Wang3Hanping Wang4Xiaotong Zhang5Li Zhang6Kaifeng Xu7Department of Pulmonary and Critical Care Medicine Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College Beijing ChinaDepartment of Pathology Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College Beijing ChinaDepartment of Pathology Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College Beijing ChinaDepartment of Pulmonary and Critical Care Medicine Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College Beijing ChinaDepartment of Pulmonary and Critical Care Medicine Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College Beijing ChinaDepartment of Pulmonary and Critical Care Medicine Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College Beijing ChinaDepartment of Pulmonary and Critical Care Medicine Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College Beijing ChinaDepartment of Pulmonary and Critical Care Medicine Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College Beijing ChinaABSTRACT Background Inflammatory myofibroblastic tumor (IMT) is a rare intermediate‐grade neoplasm. It presents a great challenge in diagnosis and treatment. This study aims to identify the clinicopathological characteristics of IMT. Methods A retrospective study was conducted, enrolling patients with IMT at Peking Union Medical College Hospital from January 2013 to October 2023. Clinical information, treatments, and efficacy were analyzed. Results A total of 72 patients were enrolled, including 38 men and 34 women, with a median age of 46.5 years. The most common primary site included the lung (n = 15, 20.8%), intestinal tract (n = 8, 11.1%), abdominal cavity (n = 7, 9.7%), and nasal sinus (n = 5, 6.9%). Thirty patients harbored anaplastic lymphoma kinase (ALK) fusion genes; Sixty‐five (90.3%) patients underwent surgical resection, and 11 of them had postoperative recurrence. Thirty patients received systemic therapy, including nonsteroidal anti‐inflammatory drugs (n = 1), steroids (n = 5), chemotherapy (n = 7), targeted therapy (n = 2), and immune checkpoint inhibitor (n = 1). Conclusions The most common site of IMT is the lung. Surgery is the main treatment for IMT, and postoperative adjuvant therapy for ALK‐positive patients needs to be focused. The molecular testing is essential for all patients diagnosed with IMTs. Systemic treatment needs further research.https://doi.org/10.1111/1759-7714.15496anaplastic lymphoma kinasechemotherapyinflammatory myofibroblastic tumortargeted therapy |
| spellingShingle | Xiaoyan Si Shafei Wu Ruie Feng Mengzhao Wang Hanping Wang Xiaotong Zhang Li Zhang Kaifeng Xu Clinicopathological Characteristics of Inflammatory Myofibroblastic Tumor: A Single Center Retrospective Cohort Study Thoracic Cancer anaplastic lymphoma kinase chemotherapy inflammatory myofibroblastic tumor targeted therapy |
| title | Clinicopathological Characteristics of Inflammatory Myofibroblastic Tumor: A Single Center Retrospective Cohort Study |
| title_full | Clinicopathological Characteristics of Inflammatory Myofibroblastic Tumor: A Single Center Retrospective Cohort Study |
| title_fullStr | Clinicopathological Characteristics of Inflammatory Myofibroblastic Tumor: A Single Center Retrospective Cohort Study |
| title_full_unstemmed | Clinicopathological Characteristics of Inflammatory Myofibroblastic Tumor: A Single Center Retrospective Cohort Study |
| title_short | Clinicopathological Characteristics of Inflammatory Myofibroblastic Tumor: A Single Center Retrospective Cohort Study |
| title_sort | clinicopathological characteristics of inflammatory myofibroblastic tumor a single center retrospective cohort study |
| topic | anaplastic lymphoma kinase chemotherapy inflammatory myofibroblastic tumor targeted therapy |
| url | https://doi.org/10.1111/1759-7714.15496 |
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