Does corticosteroid treatment affect the progression of pediatric IgA nephropathy – a systematic review and meta-analysis
Immunoglobulin A nephropathy (IgAN) is an autoimmune disease in pediatric patients, with corticosteroid (CS) treatment remaining controversial. This meta-analysis evaluates the efficacy and safety of CS in pediatric IgAN patients. A systematic search of PubMed, ProQuest, and Wiley identified six stu...
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| Format: | Article |
| Language: | English |
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Termedia Publishing House
2025-03-01
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| Series: | Pediatria Polska |
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| Online Access: | https://www.termedia.pl/Does-corticosteroid-treatment-affect-the-progression-of-pediatric-IgA-nephropathy-a-systematic-review-and-meta-analysis,127,55751,1,1.html |
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| author | Bebby Shelby Cynthia Cynthia Wida Ratna Sari Erika Aini Putri Yoga Eka Prayuda Aditya Primadana Andro Pramana Witarto |
| author_facet | Bebby Shelby Cynthia Cynthia Wida Ratna Sari Erika Aini Putri Yoga Eka Prayuda Aditya Primadana Andro Pramana Witarto |
| author_sort | Bebby Shelby |
| collection | DOAJ |
| description | Immunoglobulin A nephropathy (IgAN) is an autoimmune disease in pediatric patients, with corticosteroid (CS) treatment remaining controversial. This meta-analysis evaluates the efficacy and safety of CS in pediatric IgAN patients. A systematic search of PubMed, ProQuest, and Wiley identified six studies with 208 patients. Outcomes included estimated glomerular filtration rate (eGFR), events of renal insufficiency, end-stage renal disease (ESRD), proteinuria, hematuria, IgA deposits, and side effects. Corticosteroid treatment showed a significant increase in eGFR (mean differences – MD: 11.84 [0.73–22.95] ml/min/1.73 m2), lower odds of having ESRD (odds ratios – OR: 0.21 [0.05–0.94]) and heavy proteinuria (OR: 0.15 [0.04–0.57]), and significant reduction in dipstick hematuria (MD: 2.89 [–3.85 to –1.93]). However, IgA deposits persisted despite CS treatment. Corticosteroid side effects were minimal. Corticosteroids may reduce glomerular damage and preserve renal function in pediatric IgAN patients, but limitations in addressing IgA deposits suggest the need for additional therapies. |
| format | Article |
| id | doaj-art-30b2a06e4d9d4efeabf5acd472668797 |
| institution | Kabale University |
| issn | 0031-3939 2300-8660 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Pediatria Polska |
| spelling | doaj-art-30b2a06e4d9d4efeabf5acd4726687972025-08-20T03:49:28ZengTermedia Publishing HousePediatria Polska0031-39392300-86602025-03-011001748510.5114/polp.2025.14849355751Does corticosteroid treatment affect the progression of pediatric IgA nephropathy – a systematic review and meta-analysisBebby ShelbyCynthia CynthiaWida Ratna SariErika Aini PutriYoga Eka PrayudaAditya PrimadanaAndro Pramana WitartoImmunoglobulin A nephropathy (IgAN) is an autoimmune disease in pediatric patients, with corticosteroid (CS) treatment remaining controversial. This meta-analysis evaluates the efficacy and safety of CS in pediatric IgAN patients. A systematic search of PubMed, ProQuest, and Wiley identified six studies with 208 patients. Outcomes included estimated glomerular filtration rate (eGFR), events of renal insufficiency, end-stage renal disease (ESRD), proteinuria, hematuria, IgA deposits, and side effects. Corticosteroid treatment showed a significant increase in eGFR (mean differences – MD: 11.84 [0.73–22.95] ml/min/1.73 m2), lower odds of having ESRD (odds ratios – OR: 0.21 [0.05–0.94]) and heavy proteinuria (OR: 0.15 [0.04–0.57]), and significant reduction in dipstick hematuria (MD: 2.89 [–3.85 to –1.93]). However, IgA deposits persisted despite CS treatment. Corticosteroid side effects were minimal. Corticosteroids may reduce glomerular damage and preserve renal function in pediatric IgAN patients, but limitations in addressing IgA deposits suggest the need for additional therapies.https://www.termedia.pl/Does-corticosteroid-treatment-affect-the-progression-of-pediatric-IgA-nephropathy-a-systematic-review-and-meta-analysis,127,55751,1,1.htmliga nephropathy pediatric meta-analysis treatment corticosteroid |
| spellingShingle | Bebby Shelby Cynthia Cynthia Wida Ratna Sari Erika Aini Putri Yoga Eka Prayuda Aditya Primadana Andro Pramana Witarto Does corticosteroid treatment affect the progression of pediatric IgA nephropathy – a systematic review and meta-analysis Pediatria Polska iga nephropathy pediatric meta-analysis treatment corticosteroid |
| title | Does corticosteroid treatment affect the progression of pediatric IgA nephropathy – a systematic review and meta-analysis |
| title_full | Does corticosteroid treatment affect the progression of pediatric IgA nephropathy – a systematic review and meta-analysis |
| title_fullStr | Does corticosteroid treatment affect the progression of pediatric IgA nephropathy – a systematic review and meta-analysis |
| title_full_unstemmed | Does corticosteroid treatment affect the progression of pediatric IgA nephropathy – a systematic review and meta-analysis |
| title_short | Does corticosteroid treatment affect the progression of pediatric IgA nephropathy – a systematic review and meta-analysis |
| title_sort | does corticosteroid treatment affect the progression of pediatric iga nephropathy a systematic review and meta analysis |
| topic | iga nephropathy pediatric meta-analysis treatment corticosteroid |
| url | https://www.termedia.pl/Does-corticosteroid-treatment-affect-the-progression-of-pediatric-IgA-nephropathy-a-systematic-review-and-meta-analysis,127,55751,1,1.html |
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