O-GlcNAcylation of FOXK1 co-opts BAP1 to orchestrate the E2F pathway and promotes oncogenesis

O-GlcNAcylation of FOXK1 co-opts BAP1 to orchestrate the E2F pathway and promotes oncogenesis

Abstract The E2F transcription factors constitute a core transcriptional network that governs cell division and oncogenesis in multi-cellular organisms, although their molecular mechanisms remain incompletely understood. Here, we show that elevated expression of the transcription factor FOXK1 promot...

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Main Authors: Oumaima Ahmed, Louis Masclef, Nicholas Iannantuono, Jessica Gagnon, Mila Gushul-Leclaire, Karine Boulay, Benjamin Estavoyer, Mohamed Echbicheb, Kalidou Ali Boubacar, Marty Poy, Amina Boubekeur, Saad Menggad, Alejandro Schcolnik-Cabrera, Aurelio Balsalobre, Eric Bonneil, Pierre Thibault, Laura Hulea, Frédérick A. Mallette, Jacques Drouin, Yoshiaki Tanaka, El Bachir Affar
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61022-7
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