Orofacial Granulomatosis among Pediatric Patients Well Controlled by Corticosteroid Treatment: A Rare Case Series
Orofacial granulomatosis (OFG) is a rare disease entity characterized by nonnecrotizing granulomatous inflammation in the oral and maxillofacial regions, typically characterized by recurrent or persistent edema, primarily in the lips and occasionally in the gingiva. OFG is often associated with Croh...
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | Case Reports in Pediatrics |
| Online Access: | http://dx.doi.org/10.1155/2024/5685686 |
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| author | Taku Kimura Ken-Ichiro Sakata Shunichiro Takezaki Takuya Asaka Shohei Oshima Aya Yanagawa-Matsuda Yoshimasa Kitagawa |
| author_facet | Taku Kimura Ken-Ichiro Sakata Shunichiro Takezaki Takuya Asaka Shohei Oshima Aya Yanagawa-Matsuda Yoshimasa Kitagawa |
| author_sort | Taku Kimura |
| collection | DOAJ |
| description | Orofacial granulomatosis (OFG) is a rare disease entity characterized by nonnecrotizing granulomatous inflammation in the oral and maxillofacial regions, typically characterized by recurrent or persistent edema, primarily in the lips and occasionally in the gingiva. OFG is often associated with Crohn’s disease and sarcoidosis, and an accurate diagnosis requires systemic examination of patients. Pediatric patients possess unique oral conditions where dental plaque rapidly forms, especially during tooth replacement due to tooth crowding. Moreover, controlling oral hygiene can be challenging, rendering it difficult to distinguish plaque-induced gingivitis from nonplaque-induced gingivitis. We elucidate the reports of pediatric patients who developed OFG in the lips and/or gingiva alone, which was well controlled through corticosteroid treatment. The patients demonstrated recurrent lips and/or gingival swelling with redness, which failed to improve despite oral health care and treatment with antibiotics and/or corticosteroid ointment. Incision biopsy was performed, which demonstrated granulomatous inflammation. Further systemic examination ruled out Crohn’s disease and sarcoidosis and confirmed OFG diagnosis. Corticosteroid treatment orally or through gargling was administered to the patients, which provided improvement of symptoms after 1 month. As OFG may be associated with intractable diseases, monitoring the patient regularly is crucial. Pediatric patients with OFG require a collaborative approach with pediatricians and pediatric dentists to manage their oral and overall health. |
| format | Article |
| id | doaj-art-30a967fd30e7419198e6321a50aa7854 |
| institution | Kabale University |
| issn | 2090-6811 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pediatrics |
| spelling | doaj-art-30a967fd30e7419198e6321a50aa78542025-02-03T05:56:54ZengWileyCase Reports in Pediatrics2090-68112024-01-01202410.1155/2024/5685686Orofacial Granulomatosis among Pediatric Patients Well Controlled by Corticosteroid Treatment: A Rare Case SeriesTaku Kimura0Ken-Ichiro Sakata1Shunichiro Takezaki2Takuya Asaka3Shohei Oshima4Aya Yanagawa-Matsuda5Yoshimasa Kitagawa6Department of Oral Diagnosis and MedicineDepartment of Oral Diagnosis and MedicineDepartment of PediatricsDepartment of Oral Diagnosis and MedicineDepartment of Dentistry for Children and Disabled PersonDepartment of Vascular BiologyDepartment of Oral Diagnosis and MedicineOrofacial granulomatosis (OFG) is a rare disease entity characterized by nonnecrotizing granulomatous inflammation in the oral and maxillofacial regions, typically characterized by recurrent or persistent edema, primarily in the lips and occasionally in the gingiva. OFG is often associated with Crohn’s disease and sarcoidosis, and an accurate diagnosis requires systemic examination of patients. Pediatric patients possess unique oral conditions where dental plaque rapidly forms, especially during tooth replacement due to tooth crowding. Moreover, controlling oral hygiene can be challenging, rendering it difficult to distinguish plaque-induced gingivitis from nonplaque-induced gingivitis. We elucidate the reports of pediatric patients who developed OFG in the lips and/or gingiva alone, which was well controlled through corticosteroid treatment. The patients demonstrated recurrent lips and/or gingival swelling with redness, which failed to improve despite oral health care and treatment with antibiotics and/or corticosteroid ointment. Incision biopsy was performed, which demonstrated granulomatous inflammation. Further systemic examination ruled out Crohn’s disease and sarcoidosis and confirmed OFG diagnosis. Corticosteroid treatment orally or through gargling was administered to the patients, which provided improvement of symptoms after 1 month. As OFG may be associated with intractable diseases, monitoring the patient regularly is crucial. Pediatric patients with OFG require a collaborative approach with pediatricians and pediatric dentists to manage their oral and overall health.http://dx.doi.org/10.1155/2024/5685686 |
| spellingShingle | Taku Kimura Ken-Ichiro Sakata Shunichiro Takezaki Takuya Asaka Shohei Oshima Aya Yanagawa-Matsuda Yoshimasa Kitagawa Orofacial Granulomatosis among Pediatric Patients Well Controlled by Corticosteroid Treatment: A Rare Case Series Case Reports in Pediatrics |
| title | Orofacial Granulomatosis among Pediatric Patients Well Controlled by Corticosteroid Treatment: A Rare Case Series |
| title_full | Orofacial Granulomatosis among Pediatric Patients Well Controlled by Corticosteroid Treatment: A Rare Case Series |
| title_fullStr | Orofacial Granulomatosis among Pediatric Patients Well Controlled by Corticosteroid Treatment: A Rare Case Series |
| title_full_unstemmed | Orofacial Granulomatosis among Pediatric Patients Well Controlled by Corticosteroid Treatment: A Rare Case Series |
| title_short | Orofacial Granulomatosis among Pediatric Patients Well Controlled by Corticosteroid Treatment: A Rare Case Series |
| title_sort | orofacial granulomatosis among pediatric patients well controlled by corticosteroid treatment a rare case series |
| url | http://dx.doi.org/10.1155/2024/5685686 |
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