Langerhan′s cell histiocytosis: A single institutional experience
<b>Background:</b> Langerhans cell histiocytosis (LCH) is a disease that primarily affects bone but can be associated with a clinical spectrum that ranges from a solitary bone lesion with a favorable natural history to a multisystem, life-threatening disease process. <b>Aim:</b&...
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| Format: | Article |
| Language: | English |
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Thieme Medical and Scientific Publishers Pvt. Ltd.
2010-01-01
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| Series: | Indian Journal of Medical and Paediatric Oncology |
| Subjects: | |
| Online Access: | http://www.ijmpo.org/article.asp?issn=0971-5851;year=2010;volume=31;issue=2;spage=51;epage=53;aulast=Singh |
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| author | Singh Tejinder Satheesh C Appaji L Aruna Kumari B Mamatha H Giri G Rao Clementina |
| author_facet | Singh Tejinder Satheesh C Appaji L Aruna Kumari B Mamatha H Giri G Rao Clementina |
| author_sort | Singh Tejinder |
| collection | DOAJ |
| description | <b>Background:</b> Langerhans cell histiocytosis (LCH) is a disease that primarily affects bone but can be associated with a clinical spectrum that ranges from a solitary bone lesion with a favorable natural history to a multisystem, life-threatening disease process. <b>Aim:</b> We analyzed our single institutional experience of managing children with LCH. <b>Settings and Design:</b> A total of 40 children of LCH, managed in tertiary cancer center in South India in the period from 2001 to 2005, were evaluated retrospectively. <b>Materials and Methods:</b> Clinicopathological features, laboratory findings, treatment modalities and long-term outcome were analyzed. <b>Results:</b> Children were aged between 2 months and 12 years, with a mean of 3 years. Majority of the children were below 5 years of age. Group B constituted a bulk of children. Disseminated cases were less (five patients). Liver function dysfunction was seen in four (10%) children. Pulmonary interstitial infiltrates were seen in two (5%) cases. Diabetes insipidus manifested in three patients. There was one death. <b>Conclusion:</b> A better understanding of the etiology and pathogenesis of LCH will result in more directed and efficacious treatment regimens. |
| format | Article |
| id | doaj-art-30a8e7d30c894fae87e5ea3faf7c4485 |
| institution | OA Journals |
| issn | 0971-5851 0975-2129 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | Indian Journal of Medical and Paediatric Oncology |
| spelling | doaj-art-30a8e7d30c894fae87e5ea3faf7c44852025-08-20T01:51:03ZengThieme Medical and Scientific Publishers Pvt. Ltd.Indian Journal of Medical and Paediatric Oncology0971-58510975-21292010-01-013125153Langerhan′s cell histiocytosis: A single institutional experienceSingh TejinderSatheesh CAppaji LAruna Kumari BMamatha HGiri GRao Clementina<b>Background:</b> Langerhans cell histiocytosis (LCH) is a disease that primarily affects bone but can be associated with a clinical spectrum that ranges from a solitary bone lesion with a favorable natural history to a multisystem, life-threatening disease process. <b>Aim:</b> We analyzed our single institutional experience of managing children with LCH. <b>Settings and Design:</b> A total of 40 children of LCH, managed in tertiary cancer center in South India in the period from 2001 to 2005, were evaluated retrospectively. <b>Materials and Methods:</b> Clinicopathological features, laboratory findings, treatment modalities and long-term outcome were analyzed. <b>Results:</b> Children were aged between 2 months and 12 years, with a mean of 3 years. Majority of the children were below 5 years of age. Group B constituted a bulk of children. Disseminated cases were less (five patients). Liver function dysfunction was seen in four (10%) children. Pulmonary interstitial infiltrates were seen in two (5%) cases. Diabetes insipidus manifested in three patients. There was one death. <b>Conclusion:</b> A better understanding of the etiology and pathogenesis of LCH will result in more directed and efficacious treatment regimens.http://www.ijmpo.org/article.asp?issn=0971-5851;year=2010;volume=31;issue=2;spage=51;epage=53;aulast=Singh<i>Bone lesionchemotherapyLangerhan′s cell histiocytosis</i> |
| spellingShingle | Singh Tejinder Satheesh C Appaji L Aruna Kumari B Mamatha H Giri G Rao Clementina Langerhan′s cell histiocytosis: A single institutional experience Indian Journal of Medical and Paediatric Oncology <i>Bone lesion chemotherapy Langerhan′s cell histiocytosis</i> |
| title | Langerhan′s cell histiocytosis: A single institutional experience |
| title_full | Langerhan′s cell histiocytosis: A single institutional experience |
| title_fullStr | Langerhan′s cell histiocytosis: A single institutional experience |
| title_full_unstemmed | Langerhan′s cell histiocytosis: A single institutional experience |
| title_short | Langerhan′s cell histiocytosis: A single institutional experience |
| title_sort | langerhan x2032 s cell histiocytosis a single institutional experience |
| topic | <i>Bone lesion chemotherapy Langerhan′s cell histiocytosis</i> |
| url | http://www.ijmpo.org/article.asp?issn=0971-5851;year=2010;volume=31;issue=2;spage=51;epage=53;aulast=Singh |
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