Alternative Cell Death Pathways and Cell Metabolism
While necroptosis has for long been viewed as an accidental mode of cell death triggered by physical or chemical damage, it has become clear over the last years that necroptosis can also represent a programmed form of cell death in mammalian cells. Key discoveries in the field of cell death research...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | International Journal of Cell Biology |
| Online Access: | http://dx.doi.org/10.1155/2013/463637 |
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| _version_ | 1832552837747310592 |
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| author | Simone Fulda |
| author_facet | Simone Fulda |
| author_sort | Simone Fulda |
| collection | DOAJ |
| description | While necroptosis has for long been viewed as an accidental mode of cell death triggered by physical or chemical damage, it has become clear over the last years that necroptosis can also represent a programmed form of cell death in mammalian cells. Key discoveries in the field of cell death research, including the identification of critical components of the necroptotic machinery, led to a revised concept of cell death signaling programs. Several regulatory check and balances are in place in order to ensure that necroptosis is tightly controlled according to environmental cues and cellular needs. This network of regulatory mechanisms includes metabolic pathways, especially those linked to mitochondrial signaling events. A better understanding of these signal transduction mechanisms will likely contribute to open new avenues to exploit our knowledge on the regulation of necroptosis signaling for therapeutic application in the treatment of human diseases. |
| format | Article |
| id | doaj-art-30a43b5c10734b288a9fcb8f2a92a1f3 |
| institution | Kabale University |
| issn | 1687-8876 1687-8884 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Cell Biology |
| spelling | doaj-art-30a43b5c10734b288a9fcb8f2a92a1f32025-02-03T05:57:33ZengWileyInternational Journal of Cell Biology1687-88761687-88842013-01-01201310.1155/2013/463637463637Alternative Cell Death Pathways and Cell MetabolismSimone Fulda0Institute for Experimental Cancer Research in Pediatrics, Goethe-University Frankfurt, Komturstraße 3a, 60528 Frankfurt, GermanyWhile necroptosis has for long been viewed as an accidental mode of cell death triggered by physical or chemical damage, it has become clear over the last years that necroptosis can also represent a programmed form of cell death in mammalian cells. Key discoveries in the field of cell death research, including the identification of critical components of the necroptotic machinery, led to a revised concept of cell death signaling programs. Several regulatory check and balances are in place in order to ensure that necroptosis is tightly controlled according to environmental cues and cellular needs. This network of regulatory mechanisms includes metabolic pathways, especially those linked to mitochondrial signaling events. A better understanding of these signal transduction mechanisms will likely contribute to open new avenues to exploit our knowledge on the regulation of necroptosis signaling for therapeutic application in the treatment of human diseases.http://dx.doi.org/10.1155/2013/463637 |
| spellingShingle | Simone Fulda Alternative Cell Death Pathways and Cell Metabolism International Journal of Cell Biology |
| title | Alternative Cell Death Pathways and Cell Metabolism |
| title_full | Alternative Cell Death Pathways and Cell Metabolism |
| title_fullStr | Alternative Cell Death Pathways and Cell Metabolism |
| title_full_unstemmed | Alternative Cell Death Pathways and Cell Metabolism |
| title_short | Alternative Cell Death Pathways and Cell Metabolism |
| title_sort | alternative cell death pathways and cell metabolism |
| url | http://dx.doi.org/10.1155/2013/463637 |
| work_keys_str_mv | AT simonefulda alternativecelldeathpathwaysandcellmetabolism |