METABOLIC EFFECTS OF STATINS AND CLINICAL MANIFESTATIONS OF ATHEROSCLEROSIS
Thus review presents the modern concept of atherosclerosis and its main pathophysiological mechanisms, such as lipid peroxidation and inflammation. The authors describe the underlying mechanisms of the statins’ influence on clinical manifestations of atherosclerosis, which are related to lipid-lower...
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| Main Authors: | , |
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| Format: | Article |
| Language: | Russian |
| Published: |
«FIRMA «SILICEA» LLC
2012-04-01
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| Series: | Российский кардиологический журнал |
| Subjects: | |
| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/1214 |
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| Summary: | Thus review presents the modern concept of atherosclerosis and its main pathophysiological mechanisms, such as lipid peroxidation and inflammation. The authors describe the underlying mechanisms of the statins’ influence on clinical manifestations of atherosclerosis, which are related to lipid-lowering, pleiotropic, and metabolic effects of statins. Complex metabolic influences of statins are also discussed, including their effects on insulin resistance, glycemia, lipid profile (triglycerides and high-density lipoprotein cholesterol), uric acid, and markers of inflammation and lipid peroxidation. Finally, the impact of statin therapy on major cardiovascular risk factors, such as arterial hypertension and obesity, is debated. |
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| ISSN: | 1560-4071 2618-7620 |