Investigating a new Dillenia ovata endophytic bacteria to produce antioxidants and anti-diabetes activity in vitro and in vivo
A novel endophytic bacterium, Bacillus sp. DO-R5, with strong antioxidant and anti-diabetic properties, was isolated from Dillenia ovata, a traditional Vietnamese medicinal plant. Bacillus sp. DO-R5 was identified using morphological characteristics, SEM, and 16S rRNA sequencing, demonstrated the hi...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-12-01
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| Series: | Biotechnology Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2215017X25000487 |
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| author | Linh Chi Tran Chong Kim Thien Duc Tuan Trong Nguyen Duy Toan Pham Danh Thai Luu Trang Thi Xuan Dai |
| author_facet | Linh Chi Tran Chong Kim Thien Duc Tuan Trong Nguyen Duy Toan Pham Danh Thai Luu Trang Thi Xuan Dai |
| author_sort | Linh Chi Tran |
| collection | DOAJ |
| description | A novel endophytic bacterium, Bacillus sp. DO-R5, with strong antioxidant and anti-diabetic properties, was isolated from Dillenia ovata, a traditional Vietnamese medicinal plant. Bacillus sp. DO-R5 was identified using morphological characteristics, SEM, and 16S rRNA sequencing, demonstrated the highest bioactivity among the 19 isolates. Optimal fermentation conditions (8.9 g/L D-glucose, pH 7.5, 38 °C, and 70.5 h) were determined using the Box-Behnken design. Under these conditions, Bacillus sp. DO-R5 significantly enhanced the production of bioactive compounds including diosmin, rutin, and chlorogenic acid, and exhibited improved in vitro antioxidant, anti-inflammatory, and anti-diabetic activities. In vivo, the extract effectively reduced blood glucose, regulated lipid profiles, supported weight control, and protected organs. These findings emphasize the potential therapeutic use of D. ovata endophytic bacteria as a natural source of anti-diabetic drugs. |
| format | Article |
| id | doaj-art-309d7a6a4e90463ebd1574a9e5b409a2 |
| institution | Kabale University |
| issn | 2215-017X |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biotechnology Reports |
| spelling | doaj-art-309d7a6a4e90463ebd1574a9e5b409a22025-08-25T04:14:28ZengElsevierBiotechnology Reports2215-017X2025-12-0148e0092110.1016/j.btre.2025.e00921Investigating a new Dillenia ovata endophytic bacteria to produce antioxidants and anti-diabetes activity in vitro and in vivoLinh Chi Tran0Chong Kim Thien Duc1Tuan Trong Nguyen2Duy Toan Pham3Danh Thai Luu4Trang Thi Xuan Dai5Institute of Food and Biotechnology, Can Tho University, Can Tho City 94000, Vietnam; Faculty of Medicine, Nam Can Tho University, Can Tho City 94000, VietnamCollege of Natural Sciences, Can Tho University, Can Tho City 94000, VietnamCollege of Natural Sciences, Can Tho University, Can Tho City 94000, VietnamCollege of Natural Sciences, Can Tho University, Can Tho City 94000, VietnamCollege of Agriculture, Can Tho University, Can Tho City 94000, VietnamCollege of Natural Sciences, Can Tho University, Can Tho City 94000, Vietnam; Corresponding author at: College of Natural Sciences, Can Tho University, Can Tho City 94000, Vietnam.A novel endophytic bacterium, Bacillus sp. DO-R5, with strong antioxidant and anti-diabetic properties, was isolated from Dillenia ovata, a traditional Vietnamese medicinal plant. Bacillus sp. DO-R5 was identified using morphological characteristics, SEM, and 16S rRNA sequencing, demonstrated the highest bioactivity among the 19 isolates. Optimal fermentation conditions (8.9 g/L D-glucose, pH 7.5, 38 °C, and 70.5 h) were determined using the Box-Behnken design. Under these conditions, Bacillus sp. DO-R5 significantly enhanced the production of bioactive compounds including diosmin, rutin, and chlorogenic acid, and exhibited improved in vitro antioxidant, anti-inflammatory, and anti-diabetic activities. In vivo, the extract effectively reduced blood glucose, regulated lipid profiles, supported weight control, and protected organs. These findings emphasize the potential therapeutic use of D. ovata endophytic bacteria as a natural source of anti-diabetic drugs.http://www.sciencedirect.com/science/article/pii/S2215017X25000487AntioxidantsAnti-diabetesBacillus sp., Box-BehnkenDillenia ovataEndophytic bacteria |
| spellingShingle | Linh Chi Tran Chong Kim Thien Duc Tuan Trong Nguyen Duy Toan Pham Danh Thai Luu Trang Thi Xuan Dai Investigating a new Dillenia ovata endophytic bacteria to produce antioxidants and anti-diabetes activity in vitro and in vivo Biotechnology Reports Antioxidants Anti-diabetes Bacillus sp., Box-Behnken Dillenia ovata Endophytic bacteria |
| title | Investigating a new Dillenia ovata endophytic bacteria to produce antioxidants and anti-diabetes activity in vitro and in vivo |
| title_full | Investigating a new Dillenia ovata endophytic bacteria to produce antioxidants and anti-diabetes activity in vitro and in vivo |
| title_fullStr | Investigating a new Dillenia ovata endophytic bacteria to produce antioxidants and anti-diabetes activity in vitro and in vivo |
| title_full_unstemmed | Investigating a new Dillenia ovata endophytic bacteria to produce antioxidants and anti-diabetes activity in vitro and in vivo |
| title_short | Investigating a new Dillenia ovata endophytic bacteria to produce antioxidants and anti-diabetes activity in vitro and in vivo |
| title_sort | investigating a new dillenia ovata endophytic bacteria to produce antioxidants and anti diabetes activity in vitro and in vivo |
| topic | Antioxidants Anti-diabetes Bacillus sp., Box-Behnken Dillenia ovata Endophytic bacteria |
| url | http://www.sciencedirect.com/science/article/pii/S2215017X25000487 |
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