Synthesis of Cinnamanilide Derivatives and Their Antioxidant and Antimicrobial Activity
The amide derivatives of cinnamic acid were synthesized and their antimicrobial and antioxidant activities were investigated. The investigation of antimicrobial potentials of the compounds demonstrated a strong activity against 21 bacterial strains comprising Gram-positive and Gram-negative bacteria...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2015/208910 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849306104005132288 |
|---|---|
| author | Satish Balasaheb Nimse Dilipkumar Pal Avijit Mazumder Rupa Mazumder |
| author_facet | Satish Balasaheb Nimse Dilipkumar Pal Avijit Mazumder Rupa Mazumder |
| author_sort | Satish Balasaheb Nimse |
| collection | DOAJ |
| description | The amide derivatives of cinnamic acid were synthesized and their antimicrobial and antioxidant activities were investigated. The investigation of antimicrobial potentials of the compounds demonstrated a strong activity against 21 bacterial strains comprising Gram-positive and Gram-negative bacteria. Compounds 2a, 2b, and 3b showed strong antimicrobial activity against all microorganisms with the pMIC value ranging from 2.45 to 3.68. Compounds 2a, 3a, and 3b demonstrated strong antioxidant activity with % inhibition of the DPPH radical of 51% (±1.14), 41% (±1.01), and 50% (±1.23), respectively. These findings indicate that the amide derivatives of the cinnamic acid possess strong antibacterial and antioxidant activities. |
| format | Article |
| id | doaj-art-309bbb3d10eb41bf9e2f01f11613f069 |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-309bbb3d10eb41bf9e2f01f11613f0692025-08-20T03:55:12ZengWileyJournal of Chemistry2090-90632090-90712015-01-01201510.1155/2015/208910208910Synthesis of Cinnamanilide Derivatives and Their Antioxidant and Antimicrobial ActivitySatish Balasaheb Nimse0Dilipkumar Pal1Avijit Mazumder2Rupa Mazumder3Institute for Applied Chemistry and Department of Chemistry, Hallym University, Chuncheon 24252, Republic of KoreaInstitute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya, Bilaspur, Chhattisgarh 495009, IndiaDepartment of Pharmaceutical Technology, Noida Institute of Engineering and Technology, Greater Noida 201306, IndiaDepartment of Pharmaceutical Technology, Noida Institute of Engineering and Technology, Greater Noida 201306, IndiaThe amide derivatives of cinnamic acid were synthesized and their antimicrobial and antioxidant activities were investigated. The investigation of antimicrobial potentials of the compounds demonstrated a strong activity against 21 bacterial strains comprising Gram-positive and Gram-negative bacteria. Compounds 2a, 2b, and 3b showed strong antimicrobial activity against all microorganisms with the pMIC value ranging from 2.45 to 3.68. Compounds 2a, 3a, and 3b demonstrated strong antioxidant activity with % inhibition of the DPPH radical of 51% (±1.14), 41% (±1.01), and 50% (±1.23), respectively. These findings indicate that the amide derivatives of the cinnamic acid possess strong antibacterial and antioxidant activities.http://dx.doi.org/10.1155/2015/208910 |
| spellingShingle | Satish Balasaheb Nimse Dilipkumar Pal Avijit Mazumder Rupa Mazumder Synthesis of Cinnamanilide Derivatives and Their Antioxidant and Antimicrobial Activity Journal of Chemistry |
| title | Synthesis of Cinnamanilide Derivatives and Their Antioxidant and Antimicrobial Activity |
| title_full | Synthesis of Cinnamanilide Derivatives and Their Antioxidant and Antimicrobial Activity |
| title_fullStr | Synthesis of Cinnamanilide Derivatives and Their Antioxidant and Antimicrobial Activity |
| title_full_unstemmed | Synthesis of Cinnamanilide Derivatives and Their Antioxidant and Antimicrobial Activity |
| title_short | Synthesis of Cinnamanilide Derivatives and Their Antioxidant and Antimicrobial Activity |
| title_sort | synthesis of cinnamanilide derivatives and their antioxidant and antimicrobial activity |
| url | http://dx.doi.org/10.1155/2015/208910 |
| work_keys_str_mv | AT satishbalasahebnimse synthesisofcinnamanilidederivativesandtheirantioxidantandantimicrobialactivity AT dilipkumarpal synthesisofcinnamanilidederivativesandtheirantioxidantandantimicrobialactivity AT avijitmazumder synthesisofcinnamanilidederivativesandtheirantioxidantandantimicrobialactivity AT rupamazumder synthesisofcinnamanilidederivativesandtheirantioxidantandantimicrobialactivity |