The impact of sodium-glucose cotransporter-2 inhibitors on breast cancer and cancer-related mortality: a systematic review and meta-analysis of randomized controlled trials

The impact of sodium-glucose cotransporter-2 inhibitors on breast cancer and cancer-related mortality: a systematic review and meta-analysis of randomized controlled trials

Abstract Background SGLT-2 inhibitors (SGLT-2i) lower blood glucose levels in type 2 diabetes by inhibiting renal glucose reabsorption. While the relationship between SGLT-2i and breast cancer remains inconclusive, emerging evidence suggests potential anticancer properties. This systematic review an...

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Main Authors: Mohammad Amin Karimi, Razieh Khadem, Alireza Haraj, Mehdi Azizabadi Farahani, Pardis Charehsaz Avari Firouzeh, Arash Azizinezhad, Hasti Kianpour Raki, Mohaddeseh Belbasi, Melika Arab Bafrani, Niloofar Deravi, Yaser Khakpour, Ali Faghih Habibi, Vahid Aghsaghloo
Format: Article
Language:English
Published: BMC 2025-06-01
Series:BMC Cancer
Subjects:
SGLT-2i
DPP-4i
Breast cancer
Diabetes
Mortality
Cancer
Online Access:https://doi.org/10.1186/s12885-025-14304-8
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