Investigating the Antioxidant, Antibacterial, and Anti-biofilm Effects of Cerium Oxide Nanoparticles Synthesized by Alginate
Background: In recent years, nanoparticles have gained increasing popularity over traditional physicochemical methods for fighting pathogenic microorganisms. Due to their unique properties, cerium oxide nanoparticles (CeO2 NPs) have recently emerged as a promising candidate for biomedical applicatio...
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| Format: | Article |
| Language: | English |
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Hamadan University of Medical Sciences
2024-12-01
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| Series: | Avicenna Journal of Medical Biochemistry |
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| Online Access: | https://ajmb.umsha.ac.ir/PDF/ajmb-12-98.pdf |
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| _version_ | 1850023378856968192 |
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| author | Soudabe Mousaiyan Javad Baharara Ali Es-haghi Ehsan Yousefi |
| author_facet | Soudabe Mousaiyan Javad Baharara Ali Es-haghi Ehsan Yousefi |
| author_sort | Soudabe Mousaiyan |
| collection | DOAJ |
| description | Background: In recent years, nanoparticles have gained increasing popularity over traditional physicochemical methods for fighting pathogenic microorganisms. Due to their unique properties, cerium oxide nanoparticles (CeO2 NPs) have recently emerged as a promising candidate for biomedical applications.
Objectives: This study aimed to investigate the antibacterial effects of CeO2 NPs prepared using alginate, following the disc diffusion method.
Methods: For this purpose, four bacterial strains were used in this study: two Gram-positive [Bacillus subtilis (PTCC 1365) and Staphylococcus aureus ATCC 25923] and two Gram-negative [Escherichia coli ATCC 25922 and Pseudomonas aeruginosa ATCC 9027]. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values were measured using the microdilution method, and the anti-biofilm activity of the synthetic material was also assessed.
Results: The results demonstrated the inhibitory effects of the synthesized nanoparticles on gram-positive bacteria, with significant growth inhibition observed in S. aureus and B. subtilis, after exposure to CeO2 NPs.
Conclusion: CeO2 NPs synthesized by alginate exhibited significant antibacterial effects against Gram-positive bacteria and could disrupt biofilm structure and prevent further biofilm formation. The findings highlight the potential of CeO2 NPs synthesized by alginate as a novel antibacterial and anti-biofilm therapeutic agent. |
| format | Article |
| id | doaj-art-309a9fcc17984ed0962d9ebf0a48a20b |
| institution | DOAJ |
| issn | 2345-4113 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Hamadan University of Medical Sciences |
| record_format | Article |
| series | Avicenna Journal of Medical Biochemistry |
| spelling | doaj-art-309a9fcc17984ed0962d9ebf0a48a20b2025-08-20T03:01:23ZengHamadan University of Medical SciencesAvicenna Journal of Medical Biochemistry2345-41132024-12-011229810510.34172/ajmb.2518Investigating the Antioxidant, Antibacterial, and Anti-biofilm Effects of Cerium Oxide Nanoparticles Synthesized by AlginateSoudabe Mousaiyan0https://orcid.org/0009-0001-9206-7872Javad Baharara1Ali Es-haghi2https://orcid.org/0000-0001-5292-6161Ehsan Yousefi 3Department of Biology, Mashhad Branch, Islamic Azad University, Mashhad, IranDepartment of Biology, Mashhad Branch, Islamic Azad University, Mashhad, IranDepartment of Biology, Mashhad Branch, Islamic Azad University, Mashhad, IranDepartment of Cell and Molecular Biology & Microbiology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, IranBackground: In recent years, nanoparticles have gained increasing popularity over traditional physicochemical methods for fighting pathogenic microorganisms. Due to their unique properties, cerium oxide nanoparticles (CeO2 NPs) have recently emerged as a promising candidate for biomedical applications. Objectives: This study aimed to investigate the antibacterial effects of CeO2 NPs prepared using alginate, following the disc diffusion method. Methods: For this purpose, four bacterial strains were used in this study: two Gram-positive [Bacillus subtilis (PTCC 1365) and Staphylococcus aureus ATCC 25923] and two Gram-negative [Escherichia coli ATCC 25922 and Pseudomonas aeruginosa ATCC 9027]. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values were measured using the microdilution method, and the anti-biofilm activity of the synthetic material was also assessed. Results: The results demonstrated the inhibitory effects of the synthesized nanoparticles on gram-positive bacteria, with significant growth inhibition observed in S. aureus and B. subtilis, after exposure to CeO2 NPs. Conclusion: CeO2 NPs synthesized by alginate exhibited significant antibacterial effects against Gram-positive bacteria and could disrupt biofilm structure and prevent further biofilm formation. The findings highlight the potential of CeO2 NPs synthesized by alginate as a novel antibacterial and anti-biofilm therapeutic agent.https://ajmb.umsha.ac.ir/PDF/ajmb-12-98.pdfnanoparticlescerium oxideantibacterial effectsbiofilm |
| spellingShingle | Soudabe Mousaiyan Javad Baharara Ali Es-haghi Ehsan Yousefi Investigating the Antioxidant, Antibacterial, and Anti-biofilm Effects of Cerium Oxide Nanoparticles Synthesized by Alginate Avicenna Journal of Medical Biochemistry nanoparticles cerium oxide antibacterial effects biofilm |
| title | Investigating the Antioxidant, Antibacterial, and Anti-biofilm Effects of Cerium Oxide Nanoparticles Synthesized by Alginate |
| title_full | Investigating the Antioxidant, Antibacterial, and Anti-biofilm Effects of Cerium Oxide Nanoparticles Synthesized by Alginate |
| title_fullStr | Investigating the Antioxidant, Antibacterial, and Anti-biofilm Effects of Cerium Oxide Nanoparticles Synthesized by Alginate |
| title_full_unstemmed | Investigating the Antioxidant, Antibacterial, and Anti-biofilm Effects of Cerium Oxide Nanoparticles Synthesized by Alginate |
| title_short | Investigating the Antioxidant, Antibacterial, and Anti-biofilm Effects of Cerium Oxide Nanoparticles Synthesized by Alginate |
| title_sort | investigating the antioxidant antibacterial and anti biofilm effects of cerium oxide nanoparticles synthesized by alginate |
| topic | nanoparticles cerium oxide antibacterial effects biofilm |
| url | https://ajmb.umsha.ac.ir/PDF/ajmb-12-98.pdf |
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