Diagnostic and Predictive Recurrence Value of Plasma Fibrinogen in Patients With Adrenocortical Carcinoma
Background: The correlation between fibrinogen levels and adrenocortical carcinoma (ACC) remains unclear. This study aimed to explore the value of preoperative plasma fibrinogen as a biomarker for ACC. Methods: We identified 40 patients with ACC and 170 patients with adrenal adenoma (AA) who underwe...
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SAGE Publishing
2025-01-01
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| Series: | Clinical Medicine Insights: Oncology |
| Online Access: | https://doi.org/10.1177/11795549241271657 |
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| author | Chengquan Ma Bin Yang Quanzong Mao |
| author_facet | Chengquan Ma Bin Yang Quanzong Mao |
| author_sort | Chengquan Ma |
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| description | Background: The correlation between fibrinogen levels and adrenocortical carcinoma (ACC) remains unclear. This study aimed to explore the value of preoperative plasma fibrinogen as a biomarker for ACC. Methods: We identified 40 patients with ACC and 170 patients with adrenal adenoma (AA) who underwent surgery at our institution between 2015 and 2022. Plasma fibrinogen levels and postoperative tumor recurrence information of the patients were also recorded. For intergroup comparisons, data obtained from the AA and ACC groups were evaluated using a t -test. The cutoff value of fibrinogen level was determined using a receiver operating characteristic (ROC) curve. Results: Mean fibrinogen levels in the AA and ACC groups were 2.81 ± 0.59 g/L and 3.88 ± 1.75 g/L, respectively ( P < .001). Fibrinogen level, which can help distinguish between AA and ACC, was evaluated using the ROC curve. The cutoff fibrinogen level was estimated as 3.87 g/L according to the Youden index. With this value, the sensitivity was 62.5%, specificity was 95.7%, and the area under the ROC curve (AUC) was 0.74 ( P < .001). Fibrinogen level, which can help distinguish between recurrence and non-recurrence, was evaluated using the ROC curve. The cutoff fibrinogen level was estimated as 3.96 g/L according to the Youden index. The sensitivity, specificity, and AUC were 90%, 71.4%, and 0.85, respectively ( P < .001). Conclusion: According to the data in this study, plasma fibrinogen could be used to distinguish ACC from AA. Most importantly, plasma fibrinogen may be used to identify recurrence of postoperative ACC. |
| format | Article |
| id | doaj-art-309a3a55b158476b9d47b6da68705ab0 |
| institution | Kabale University |
| issn | 1179-5549 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | SAGE Publishing |
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| series | Clinical Medicine Insights: Oncology |
| spelling | doaj-art-309a3a55b158476b9d47b6da68705ab02025-01-07T12:03:27ZengSAGE PublishingClinical Medicine Insights: Oncology1179-55492025-01-011910.1177/11795549241271657Diagnostic and Predictive Recurrence Value of Plasma Fibrinogen in Patients With Adrenocortical CarcinomaChengquan Ma0Bin Yang1Quanzong Mao2Department of Urology, Tianjin Medical University General Hospital, Tianjin, ChinaDepartment of Urology, The Affiliated Hospital of Qingdao University, Qingdao, ChinaDepartment of Urology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, ChinaBackground: The correlation between fibrinogen levels and adrenocortical carcinoma (ACC) remains unclear. This study aimed to explore the value of preoperative plasma fibrinogen as a biomarker for ACC. Methods: We identified 40 patients with ACC and 170 patients with adrenal adenoma (AA) who underwent surgery at our institution between 2015 and 2022. Plasma fibrinogen levels and postoperative tumor recurrence information of the patients were also recorded. For intergroup comparisons, data obtained from the AA and ACC groups were evaluated using a t -test. The cutoff value of fibrinogen level was determined using a receiver operating characteristic (ROC) curve. Results: Mean fibrinogen levels in the AA and ACC groups were 2.81 ± 0.59 g/L and 3.88 ± 1.75 g/L, respectively ( P < .001). Fibrinogen level, which can help distinguish between AA and ACC, was evaluated using the ROC curve. The cutoff fibrinogen level was estimated as 3.87 g/L according to the Youden index. With this value, the sensitivity was 62.5%, specificity was 95.7%, and the area under the ROC curve (AUC) was 0.74 ( P < .001). Fibrinogen level, which can help distinguish between recurrence and non-recurrence, was evaluated using the ROC curve. The cutoff fibrinogen level was estimated as 3.96 g/L according to the Youden index. The sensitivity, specificity, and AUC were 90%, 71.4%, and 0.85, respectively ( P < .001). Conclusion: According to the data in this study, plasma fibrinogen could be used to distinguish ACC from AA. Most importantly, plasma fibrinogen may be used to identify recurrence of postoperative ACC.https://doi.org/10.1177/11795549241271657 |
| spellingShingle | Chengquan Ma Bin Yang Quanzong Mao Diagnostic and Predictive Recurrence Value of Plasma Fibrinogen in Patients With Adrenocortical Carcinoma Clinical Medicine Insights: Oncology |
| title | Diagnostic and Predictive Recurrence Value of Plasma Fibrinogen in Patients With Adrenocortical Carcinoma |
| title_full | Diagnostic and Predictive Recurrence Value of Plasma Fibrinogen in Patients With Adrenocortical Carcinoma |
| title_fullStr | Diagnostic and Predictive Recurrence Value of Plasma Fibrinogen in Patients With Adrenocortical Carcinoma |
| title_full_unstemmed | Diagnostic and Predictive Recurrence Value of Plasma Fibrinogen in Patients With Adrenocortical Carcinoma |
| title_short | Diagnostic and Predictive Recurrence Value of Plasma Fibrinogen in Patients With Adrenocortical Carcinoma |
| title_sort | diagnostic and predictive recurrence value of plasma fibrinogen in patients with adrenocortical carcinoma |
| url | https://doi.org/10.1177/11795549241271657 |
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