TSG Extends the Longevity of <i>Caenorhabditis elegans</i> by Targeting the DAF-16/SKN-1/SIR-2.1-Mediated Mitochondrial Quality Control Process
The improvement of mitochondrial function is described as a strategy for alleviating oxidative stress and intervening in the aging process. 2,3,5,4′-Tetrahydroxystilbene-2-<i>O</i>-<i>β</i>-D-glucoside (TSG) is one of the major bioactive components isolated from <i>Poly...
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2024-09-01
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| Series: | Antioxidants |
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| author | Menglu Sun Congmin Wei Yehui Gao Xinyan Chen Kaixin Zhong Yingzi Li Zhou Yang Yihuai Gao Hongbing Wang |
| author_facet | Menglu Sun Congmin Wei Yehui Gao Xinyan Chen Kaixin Zhong Yingzi Li Zhou Yang Yihuai Gao Hongbing Wang |
| author_sort | Menglu Sun |
| collection | DOAJ |
| description | The improvement of mitochondrial function is described as a strategy for alleviating oxidative stress and intervening in the aging process. 2,3,5,4′-Tetrahydroxystilbene-2-<i>O</i>-<i>β</i>-D-glucoside (TSG) is one of the major bioactive components isolated from <i>Polygonum multiflorum</i> Thunb, and it exhibits multiple activities, including antioxidant and anti-inflammatory effects. In this study, we found that 200 μM TSG significantly extended the mean lifespan of <i>Caenorhabditis elegans</i> by 16.48% and improved health status by delaying age-associated physiological decline in worms. The longevity prolongation effect of TSG depended on the regulation of the mitochondrial quality control process mediated by DAF-16/FOXO, SKN-1/Nrf2 and SIR-2.1/SIRT1 to improve mitochondrial function. Moreover, TSG treatment obviously alleviated the proteotoxicity of β-amyloid and tau proteins in worms. Our findings indicated that TSG is a promising natural product for preventing aging and treating aging-associated neurodegenerative diseases by regulating the mitochondrial quality control process to improve mitochondrial function. |
| format | Article |
| id | doaj-art-3098893937d045d0a05e9a0d55cd59a7 |
| institution | OA Journals |
| issn | 2076-3921 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | MDPI AG |
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| series | Antioxidants |
| spelling | doaj-art-3098893937d045d0a05e9a0d55cd59a72025-08-20T01:55:57ZengMDPI AGAntioxidants2076-39212024-09-01139108610.3390/antiox13091086TSG Extends the Longevity of <i>Caenorhabditis elegans</i> by Targeting the DAF-16/SKN-1/SIR-2.1-Mediated Mitochondrial Quality Control ProcessMenglu Sun0Congmin Wei1Yehui Gao2Xinyan Chen3Kaixin Zhong4Yingzi Li5Zhou Yang6Yihuai Gao7Hongbing Wang8Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai 200092, ChinaInstitute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai 200092, ChinaInstitute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai 200092, ChinaInstitute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai 200092, ChinaInstitute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai 200092, ChinaInstitute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai 200092, ChinaTongji Alpha Natural Medicine Research Institute, Tongji University, Shanghai 200070, ChinaTongji Alpha Natural Medicine Research Institute, Tongji University, Shanghai 200070, ChinaInstitute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai 200092, ChinaThe improvement of mitochondrial function is described as a strategy for alleviating oxidative stress and intervening in the aging process. 2,3,5,4′-Tetrahydroxystilbene-2-<i>O</i>-<i>β</i>-D-glucoside (TSG) is one of the major bioactive components isolated from <i>Polygonum multiflorum</i> Thunb, and it exhibits multiple activities, including antioxidant and anti-inflammatory effects. In this study, we found that 200 μM TSG significantly extended the mean lifespan of <i>Caenorhabditis elegans</i> by 16.48% and improved health status by delaying age-associated physiological decline in worms. The longevity prolongation effect of TSG depended on the regulation of the mitochondrial quality control process mediated by DAF-16/FOXO, SKN-1/Nrf2 and SIR-2.1/SIRT1 to improve mitochondrial function. Moreover, TSG treatment obviously alleviated the proteotoxicity of β-amyloid and tau proteins in worms. Our findings indicated that TSG is a promising natural product for preventing aging and treating aging-associated neurodegenerative diseases by regulating the mitochondrial quality control process to improve mitochondrial function.https://www.mdpi.com/2076-3921/13/9/10862,3,5,4′-Tetrahydroxystilbene-2-<i>O</i>-<i>β</i>-D-glucoside<i>Caenorhabditis elegans</i>mitochondrial functionagingneurodegenerative diseases |
| spellingShingle | Menglu Sun Congmin Wei Yehui Gao Xinyan Chen Kaixin Zhong Yingzi Li Zhou Yang Yihuai Gao Hongbing Wang TSG Extends the Longevity of <i>Caenorhabditis elegans</i> by Targeting the DAF-16/SKN-1/SIR-2.1-Mediated Mitochondrial Quality Control Process Antioxidants 2,3,5,4′-Tetrahydroxystilbene-2-<i>O</i>-<i>β</i>-D-glucoside <i>Caenorhabditis elegans</i> mitochondrial function aging neurodegenerative diseases |
| title | TSG Extends the Longevity of <i>Caenorhabditis elegans</i> by Targeting the DAF-16/SKN-1/SIR-2.1-Mediated Mitochondrial Quality Control Process |
| title_full | TSG Extends the Longevity of <i>Caenorhabditis elegans</i> by Targeting the DAF-16/SKN-1/SIR-2.1-Mediated Mitochondrial Quality Control Process |
| title_fullStr | TSG Extends the Longevity of <i>Caenorhabditis elegans</i> by Targeting the DAF-16/SKN-1/SIR-2.1-Mediated Mitochondrial Quality Control Process |
| title_full_unstemmed | TSG Extends the Longevity of <i>Caenorhabditis elegans</i> by Targeting the DAF-16/SKN-1/SIR-2.1-Mediated Mitochondrial Quality Control Process |
| title_short | TSG Extends the Longevity of <i>Caenorhabditis elegans</i> by Targeting the DAF-16/SKN-1/SIR-2.1-Mediated Mitochondrial Quality Control Process |
| title_sort | tsg extends the longevity of i caenorhabditis elegans i by targeting the daf 16 skn 1 sir 2 1 mediated mitochondrial quality control process |
| topic | 2,3,5,4′-Tetrahydroxystilbene-2-<i>O</i>-<i>β</i>-D-glucoside <i>Caenorhabditis elegans</i> mitochondrial function aging neurodegenerative diseases |
| url | https://www.mdpi.com/2076-3921/13/9/1086 |
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